CD15801

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD15801

CD15801

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Itk

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• IL2-inducible T-cell kinase

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• IL2-inducible T-cell kinase
• kinase TLK
• kinase EMT
• tyrosine-protein kinase ITK/TSK
• IL-2-inducible T-cell kinase
• T-cell-specific kinase
• interleukin-2-inducible T cell kinase

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• Emt
• Tcsk
• Tsk

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/16428

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• IL2 inducible T cell kinase
  http://metadb.riken.jp/db/mgi_rdf/MGI:96621

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_010583

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000020395

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.339927

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=186973

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• A. August, et.al., CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line., Proceedings of the National Academy of Sciences of the United States of America, 1994, 91
  http://rdf.ncbi.nlm.nih.gov/pubmed/7524075
• Raji E. Joseph, et.al., Identification of an allosteric signaling network within Tec family kinases., Journal of molecular biology, 2010, 403
  http://rdf.ncbi.nlm.nih.gov/pubmed/20826165
• J D. Siliciano, et.al., itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2., Proceedings of the National Academy of Sciences of the United States of America, 1992, 89
  http://rdf.ncbi.nlm.nih.gov/pubmed/1280821
• A. Bernards, et.al., The ltk receptor tyrosine kinase is expressed in pre-B lymphocytes and cerebral neurons and uses a non-AUG translational initiator., The EMBO journal, 1990, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/2357970
• Christine. Dierks, et.al., The ITK-SYK fusion oncogene induces a T-cell lymphoproliferative disease in mice mimicking human disease., Cancer research, 2010, 70
  http://rdf.ncbi.nlm.nih.gov/pubmed/20670954
• Yrina. Rochman, et.al., Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling., Proceedings of the National Academy of Sciences of the United States of America, 2010, 107
  http://rdf.ncbi.nlm.nih.gov/pubmed/20974963
• L. Yao, et.al., The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C., Proceedings of the National Academy of Sciences of the United States of America, 1994, 91
  http://rdf.ncbi.nlm.nih.gov/pubmed/7522330
• Qian. Qi, et.al., Interleukin-2-inducible T cell kinase (Itk) network edge dependence for the maturation of iNKT cell., The Journal of biological chemistry, 2011, 286
  http://rdf.ncbi.nlm.nih.gov/pubmed/21036902
• Hai-lan. Yao, et.al., [Effect of Itk down regulation on cytokines production in Jurkat cell]., Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology, 2010, 24
  http://rdf.ncbi.nlm.nih.gov/pubmed/21280324
• E M. Janis, et.al., Mapping of the gene for the tyrosine kinase Itk to a region of conserved synteny between mouse chromosome 11 and human chromosome 5q., Genomics, 1994, 23
  http://rdf.ncbi.nlm.nih.gov/pubmed/7829087

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• ATP binding
  http://purl.obolibrary.org/obo/GO_0005524
• kinase activity
  http://purl.obolibrary.org/obo/GO_0016301
• T cell receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0050852
• protein tyrosine kinase activity
  http://purl.obolibrary.org/obo/GO_0004713
• nucleotide binding
  http://purl.obolibrary.org/obo/GO_0000166
• metal ion binding
  http://purl.obolibrary.org/obo/GO_0046872
• transferase activity, transferring phosphorus-containing groups
  http://purl.obolibrary.org/obo/GO_0016772
• cytosol
  http://purl.obolibrary.org/obo/GO_0005829
• protein phosphorylation
  http://purl.obolibrary.org/obo/GO_0006468
• interferon-gamma production
  http://purl.obolibrary.org/obo/GO_0032609
• intracellular signal transduction
  http://purl.obolibrary.org/obo/GO_0035556
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• interleukin-4 production
  http://purl.obolibrary.org/obo/GO_0032633
• NK T cell differentiation
  http://purl.obolibrary.org/obo/GO_0001865
• non-membrane spanning protein tyrosine kinase activity
  http://purl.obolibrary.org/obo/GO_0004715
• phosphorylation
  http://purl.obolibrary.org/obo/GO_0016310
• protein kinase activity
  http://purl.obolibrary.org/obo/GO_0004672
• cytokine production
  http://purl.obolibrary.org/obo/GO_0001816
• adaptive immune response
  http://purl.obolibrary.org/obo/GO_0002250
• transferase activity
  http://purl.obolibrary.org/obo/GO_0016740
• activation of phospholipase C activity
  http://purl.obolibrary.org/obo/GO_0007202

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04660
• http://www.genome.jp/dbget-bin/www_bget?map04670
• http://www.genome.jp/dbget-bin/www_bget?map04062

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Leukocyte transendothelial migration
• Chemokine signaling pathway
• T cell receptor signaling pathway