CD16415

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD16415

CD16415

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Dgat1

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• diacylglycerol O-acyltransferase 1

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• diacylglycerol acyltransferase 1
• diacylglycerol O-acyltransferase 1
• diglyceride acyltransferase

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• Dgat
• C75990
• D15Ertd23e

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/13350

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• diacylglycerol O-acyltransferase 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1333825

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_010046

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000022555

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.22633

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=604900

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Suneil K. Koliwad, et.al., DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation., The Journal of clinical investigation, 2010, 120
  http://rdf.ncbi.nlm.nih.gov/pubmed/20124729
• Pamela J. McFie, et.al., Topological orientation of acyl-CoA:diacylglycerol acyltransferase-1 (DGAT1) and identification of a putative active site histidine and the role of the n terminus in dimer/tetramer formation., The Journal of biological chemistry, 2010, 285
  http://rdf.ncbi.nlm.nih.gov/pubmed/20876538
• Li. Liu, et.al., DGAT1 expression increases heart triglyceride content but ameliorates lipotoxicity., The Journal of biological chemistry, 2009, 284
  http://rdf.ncbi.nlm.nih.gov/pubmed/19778901
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• K F. Buhman, et.al., Mammalian acyl-CoA:cholesterol acyltransferases., Biochimica et biophysica acta, 2000, 1529
  http://rdf.ncbi.nlm.nih.gov/pubmed/11111084
• S J. Smith, et.al., Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat., Nature genetics, 2000, 25
  http://rdf.ncbi.nlm.nih.gov/pubmed/10802663
• S. Cases, et.al., Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis., Proceedings of the National Academy of Sciences of the United States of America, 1998, 95
  http://rdf.ncbi.nlm.nih.gov/pubmed/9789033
• Hubert C. Chen, et.al., Leptin modulates the effects of acyl CoA:diacylglycerol acyltransferase deficiency on murine fur and sebaceous glands., The Journal of clinical investigation, 2002, 109
  http://rdf.ncbi.nlm.nih.gov/pubmed/11805129
• Bonggi. Lee, et.al., Intestine-specific expression of acyl CoA:diacylglycerol acyltransferase 1 reverses resistance to diet-induced hepatic steatosis and obesity in Dgat1-/- mice., Journal of lipid research, 2010, 51
  http://rdf.ncbi.nlm.nih.gov/pubmed/20147738
• Bernard. Grisart, et.al., Positional candidate cloning of a QTL in dairy cattle: identification of a missense mutation in the bovine DGAT1 gene with major effect on milk yield and composition., Genome research, 2002, 12
  http://rdf.ncbi.nlm.nih.gov/pubmed/11827942

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• transferase activity, transferring acyl groups
  http://purl.obolibrary.org/obo/GO_0016746
• membrane
  http://purl.obolibrary.org/obo/GO_0016020
• membrane fraction
  http://purl.obolibrary.org/obo/GO_0005624
• endoplasmic reticulum
  http://purl.obolibrary.org/obo/GO_0005783
• transferase activity
  http://purl.obolibrary.org/obo/GO_0016740
• metabolic process
  http://purl.obolibrary.org/obo/GO_0008152
• glycerolipid metabolic process
  http://purl.obolibrary.org/obo/GO_0046486
• microsome
  http://purl.obolibrary.org/obo/GO_0005792
• insulin secretion
  http://purl.obolibrary.org/obo/GO_0030073
• 2-acylglycerol O-acyltransferase activity
  http://purl.obolibrary.org/obo/GO_0003846
• diacylglycerol O-acyltransferase activity
  http://purl.obolibrary.org/obo/GO_0004144
• diacylglycerol binding
  http://purl.obolibrary.org/obo/GO_0019992
• fatty acid binding
  http://purl.obolibrary.org/obo/GO_0005504
• integral component of membrane
  http://purl.obolibrary.org/obo/GO_0016021
• triglyceride biosynthetic process
  http://purl.obolibrary.org/obo/GO_0019432
• O-acyltransferase activity
  http://purl.obolibrary.org/obo/GO_0008374
• very-low-density lipoprotein particle assembly
  http://purl.obolibrary.org/obo/GO_0034379

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04975
• http://www.genome.jp/dbget-bin/www_bget?map00830
• http://www.genome.jp/dbget-bin/www_bget?map01100
• http://www.genome.jp/dbget-bin/www_bget?map00561

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Glycerolipid metabolism
• Fat digestion and absorption
• Metabolic pathways
• Retinol metabolism