Brain Transcriptome Database (BrainTx)
トランスクリプトームデータ
CD16617
http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD16617
CD16617(トランスクリプトームデータ)
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CD16617
トランスクリプトームデータ
遺伝子シンボル
http://metadb.riken.jp/db/BrainTx/geneSymbol
Sirt1
遺伝子名
http://metadb.riken.jp/db/BrainTx/geneName
sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)
別名
http://metadb.riken.jp/db/BrainTx/alt_name
sirtuin 1 ((silent mating type information regulation 2, homolog) 1
SIR2-like protein 1
sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)
sir2-like 1
NAD-dependent deacetylase sirtuin-1
mSIR2a
別名略称
http://metadb.riken.jp/db/BrainTx/alt_symbol
Sir2a
Sir2alpha
Sir2
AA673258
SIR2L1
NCBI遺伝子
http://metadb.riken.jp/db/BrainTx/NCBIGene
https://www.ncbi.nlm.nih.gov/gene/93759
MGI遺伝子
http://metadb.riken.jp/db/BrainTx/mgiGene
sirtuin 1
http://metadb.riken.jp/db/mgi_rdf/MGI:2135607
BrainTx遺伝子
http://metadb.riken.jp/db/BrainTx/brainTxGene
脳発現画像
http://metadb.riken.jp/db/BrainTx/brainExpressionImage
時系列発現 (小脳)
http://metadb.riken.jp/db/BrainTx/brainExpression
脳発現特異性/組織別発現
http://metadb.riken.jp/db/BrainTx/brainSpecificity
BrainTx遺伝子カテゴリー
http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory
NCBI Accession Number
http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber
https://www.ncbi.nlm.nih.gov/nuccore/NM_019812
https://www.ncbi.nlm.nih.gov/nuccore/NM_001159589
Ensembl 遺伝子
http://metadb.riken.jp/db/BrainTx/ensemblGene
http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000020063
UniGene 遺伝子
http://metadb.riken.jp/db/BrainTx/uniGene
https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.351459
OMIM ID
http://metadb.riken.jp/db/BrainTx/omim
https://www.omim.org/entry/603434?search=603434&highlight=604479
PubMed ID (PMID)
http://rdf.ncbi.nlm.nih.gov/pubmed/
Michael J. Powell, et.al., Disruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation., Cancer research, 2011, 71
http://rdf.ncbi.nlm.nih.gov/pubmed/21189328
S. Imai, et.al., Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase., Nature, 2000, 403
http://rdf.ncbi.nlm.nih.gov/pubmed/10693811
S Y. Hwang, et.al., Expression of genes involved in mammalian meiosis during the transition from egg to embryo., Molecular reproduction and development, 2001, 59
http://rdf.ncbi.nlm.nih.gov/pubmed/11389549
Jose A. Palacios, et.al., SIRT1 contributes to telomere maintenance and augments global homologous recombination., The Journal of cell biology, 2010, 191
http://rdf.ncbi.nlm.nih.gov/pubmed/21187328
Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
V. Muth, et.al., Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription., The EMBO journal, 2001, 20
http://rdf.ncbi.nlm.nih.gov/pubmed/11250901
H. Vaziri, et.al., hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase., Cell, 2001, 107
http://rdf.ncbi.nlm.nih.gov/pubmed/11672523
Rui-Hong. Wang, et.al., Liver steatosis and increased ChREBP expression in mice carrying a liver specific SIRT1 null mutation under a normal feeding condition., International journal of biological sciences, 2010, 6
http://rdf.ncbi.nlm.nih.gov/pubmed/21103071
J. Luo, et.al., Negative control of p53 by Sir2alpha promotes cell survival under stress., Cell, 2001, 107
http://rdf.ncbi.nlm.nih.gov/pubmed/11672522
Ulf H. Beier, et.al., Sirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survival., Molecular and cellular biology, 2011, 31
http://rdf.ncbi.nlm.nih.gov/pubmed/21199917
Gene Ontology
http://metadb.riken.jp/db/BrainTx/golink
nuclear chromatin
http://purl.obolibrary.org/obo/GO_0000790
negative regulation of I-kappaB kinase/NF-kappaB signaling
http://purl.obolibrary.org/obo/GO_0043124
histone deacetylation
http://purl.obolibrary.org/obo/GO_0016575
negative regulation of NF-kappaB transcription factor activity
http://purl.obolibrary.org/obo/GO_0032088
positive regulation of anti-apoptosis
http://purl.obolibrary.org/obo/GO_0045768
negative regulation of cell growth
http://purl.obolibrary.org/obo/GO_0030308
histone binding
http://purl.obolibrary.org/obo/GO_0042393
positive regulation of MHC class II biosynthetic process
http://purl.obolibrary.org/obo/GO_0045348
negative regulation of TOR signaling
http://purl.obolibrary.org/obo/GO_0032007
negative regulation of apoptotic process
http://purl.obolibrary.org/obo/GO_0043066
protein deacetylation
http://purl.obolibrary.org/obo/GO_0006476
metal ion binding
http://purl.obolibrary.org/obo/GO_0046872
positive regulation of DNA repair
http://purl.obolibrary.org/obo/GO_0045739
cytoplasm
http://purl.obolibrary.org/obo/GO_0005737
rRNA processing
http://purl.obolibrary.org/obo/GO_0006364
cellular response to starvation
http://purl.obolibrary.org/obo/GO_0009267
NAD-dependent histone deacetylase activity
http://purl.obolibrary.org/obo/GO_0017136
enzyme binding
http://purl.obolibrary.org/obo/GO_0019899
ovulation from ovarian follicle
http://purl.obolibrary.org/obo/GO_0001542
positive regulation of adaptive immune response
http://purl.obolibrary.org/obo/GO_0002821
regulation of mitotic cell cycle
http://purl.obolibrary.org/obo/GO_0007346
negative regulation of protein kinase B signaling
http://purl.obolibrary.org/obo/GO_0051898
spermatogenesis
http://purl.obolibrary.org/obo/GO_0007283
cellular response to hypoxia
http://purl.obolibrary.org/obo/GO_0071456
negative regulation of peptidyl-lysine acetylation
http://purl.obolibrary.org/obo/GO_2000757
nuclear euchromatin
http://purl.obolibrary.org/obo/GO_0005719
nuclear inner membrane
http://purl.obolibrary.org/obo/GO_0005637
negative regulation of transcription, DNA-templated
http://purl.obolibrary.org/obo/GO_0045892
positive regulation of cell proliferation
http://purl.obolibrary.org/obo/GO_0008284
histone deacetylase activity
http://purl.obolibrary.org/obo/GO_0004407
nuclear heterochromatin
http://purl.obolibrary.org/obo/GO_0005720
protein C-terminus binding
http://purl.obolibrary.org/obo/GO_0008022
nuclear envelope
http://purl.obolibrary.org/obo/GO_0005635
positive regulation of cAMP-dependent protein kinase activity
http://purl.obolibrary.org/obo/GO_2000481
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
http://purl.obolibrary.org/obo/GO_0043280
NAD-dependent protein deacetylase activity
http://purl.obolibrary.org/obo/GO_0034979
regulation of transcription, DNA-templated
http://purl.obolibrary.org/obo/GO_0006355
positive regulation of transcription from RNA polymerase II promoter
http://purl.obolibrary.org/obo/GO_0045944
protein domain specific binding
http://purl.obolibrary.org/obo/GO_0019904
NAD+ binding
http://purl.obolibrary.org/obo/GO_0070403
negative regulation of fat cell differentiation
http://purl.obolibrary.org/obo/GO_0045599
rDNA heterochromatin
http://purl.obolibrary.org/obo/GO_0033553
HLH domain binding
http://purl.obolibrary.org/obo/GO_0043398
protein deacetylase activity
http://purl.obolibrary.org/obo/GO_0033558
positive regulation of cellular senescence
http://purl.obolibrary.org/obo/GO_2000774
mitogen-activated protein kinase binding
http://purl.obolibrary.org/obo/GO_0051019
cellular response to hydrogen peroxide
http://purl.obolibrary.org/obo/GO_0070301
negative regulation of cellular senescence
http://purl.obolibrary.org/obo/GO_2000773
negative regulation of DNA damage response, signal transduction by p53 class mediator
http://purl.obolibrary.org/obo/GO_0043518
positive regulation of chromatin silencing
http://purl.obolibrary.org/obo/GO_0031937
apoptotic process
http://purl.obolibrary.org/obo/GO_0006915
identical protein binding
http://purl.obolibrary.org/obo/GO_0042802
regulation of protein import into nucleus, translocation
http://purl.obolibrary.org/obo/GO_0033158
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
http://purl.obolibrary.org/obo/GO_0042771
NAD-dependent histone deacetylase activity (H3-K9 specific)
http://purl.obolibrary.org/obo/GO_0046969
peptidyl-lysine acetylation
http://purl.obolibrary.org/obo/GO_0018394
maintenance of chromatin silencing
http://purl.obolibrary.org/obo/GO_0006344
negative regulation of transcription from RNA polymerase II promoter
http://purl.obolibrary.org/obo/GO_0000122
positive regulation of apoptotic process
http://purl.obolibrary.org/obo/GO_0043065
p53 binding
http://purl.obolibrary.org/obo/GO_0002039
zinc ion binding
http://purl.obolibrary.org/obo/GO_0008270
transcription corepressor activity
http://purl.obolibrary.org/obo/GO_0003714
single strand break repair
http://purl.obolibrary.org/obo/GO_0000012
nucleoplasm
http://purl.obolibrary.org/obo/GO_0005654
cellular response to DNA damage stimulus
http://purl.obolibrary.org/obo/GO_0006974
nucleolus
http://purl.obolibrary.org/obo/GO_0005730
negative regulation of phosphorylation
http://purl.obolibrary.org/obo/GO_0042326
cellular response to tumor necrosis factor
http://purl.obolibrary.org/obo/GO_0071356
positive regulation of macroautophagy
http://purl.obolibrary.org/obo/GO_0016239
deacetylase activity
http://purl.obolibrary.org/obo/GO_0019213
regulation of endodeoxyribonuclease activity
http://purl.obolibrary.org/obo/GO_0032071
negative regulation of helicase activity
http://purl.obolibrary.org/obo/GO_0051097
nucleus
http://purl.obolibrary.org/obo/GO_0005634
hydrolase activity
http://purl.obolibrary.org/obo/GO_0016787
pyrimidine dimer repair by nucleotide-excision repair
http://purl.obolibrary.org/obo/GO_0000720
peptidyl-lysine deacetylation
http://purl.obolibrary.org/obo/GO_0034983
PML body
http://purl.obolibrary.org/obo/GO_0016605
white fat cell differentiation
http://purl.obolibrary.org/obo/GO_0050872
negative regulation of cAMP-dependent protein kinase activity
http://purl.obolibrary.org/obo/GO_2000480
chromatin silencing complex
http://purl.obolibrary.org/obo/GO_0005677
response to oxidative stress
http://purl.obolibrary.org/obo/GO_0006979
protein ubiquitination
http://purl.obolibrary.org/obo/GO_0016567
regulation of cell proliferation
http://purl.obolibrary.org/obo/GO_0042127
proteasome-mediated ubiquitin-dependent protein catabolic process
http://purl.obolibrary.org/obo/GO_0043161
cell differentiation
http://purl.obolibrary.org/obo/GO_0030154
muscle organ development
http://purl.obolibrary.org/obo/GO_0007517
negative regulation of cellular response to testosterone stimulus
http://purl.obolibrary.org/obo/GO_2000655
negative regulation of sequence-specific DNA binding transcription factor activity
http://purl.obolibrary.org/obo/GO_0043433
transcription, DNA-templated
http://purl.obolibrary.org/obo/GO_0006351
angiogenesis
http://purl.obolibrary.org/obo/GO_0001525
protein binding
http://purl.obolibrary.org/obo/GO_0005515
regulation of apoptotic process
http://purl.obolibrary.org/obo/GO_0042981
regulation of response to stress
http://purl.obolibrary.org/obo/GO_0080134
bHLH transcription factor binding
http://purl.obolibrary.org/obo/GO_0043425
establishment of chromatin silencing
http://purl.obolibrary.org/obo/GO_0006343
negative regulation of androgen receptor signaling pathway
http://purl.obolibrary.org/obo/GO_0060766
chromatin silencing at rDNA
http://purl.obolibrary.org/obo/GO_0000183
triglyceride mobilization
http://purl.obolibrary.org/obo/GO_0006642
histone H3 deacetylation
http://purl.obolibrary.org/obo/GO_0070932
positive regulation of insulin receptor signaling pathway
http://purl.obolibrary.org/obo/GO_0046628
InterPro ID
http://metadb.riken.jp/db/BrainTx/interPro
KEGG Pathway ID
http://metadb.riken.jp/db/BrainTx/keggPathwayID
KEGG Pathway 名称
http://metadb.riken.jp/db/BrainTx/keggPathwayName
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