CD16908

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD16908

CD16908

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Tnfsf11

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• tumor necrosis factor (ligand) superfamily, member 11

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• OPG ligand
• TNF-related activation-induced cytokine
• osteoprotegerin ligand
• receptor activator of NF-kappaB ligand
• receptor activator of nuclear factor kappa B ligand
• receptor activator of nuclear factor kappa-B ligand
他3件を見る
• tumor necrosis factor (ligand) superfamily, member 11
• tumor necrosis factor ligand superfamily member 11
• tumor necrosis factor-related activation-induced cytokine

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• Ly109l
• ODF
• OPG
• OPGL
• RANKL
• Trance
他1件を見る
• osteoclast differentiation factor

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/21943

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• tumor necrosis factor (ligand) superfamily, member 11
  http://metadb.riken.jp/db/mgi_rdf/MGI:1100089

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_011613

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000022015

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.249221

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=602642

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Xiaoping. Lin, et.al., Antibody to receptor activator of NF-κB ligand ameliorates T cell-mediated periodontal bone resorption., Infection and immunity, 2011, 79
  http://rdf.ncbi.nlm.nih.gov/pubmed/21078845
• Sylvie Nathalie. Hardouin, et.al., Impaired mesenchymal stem cell differentiation and osteoclastogenesis in mice deficient for Igf2-P2 transcripts., Development (Cambridge, England), 2011, 138
  http://rdf.ncbi.nlm.nih.gov/pubmed/21148188
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• Wei. Tan, et.al., Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling., Nature, 2011, 470
  http://rdf.ncbi.nlm.nih.gov/pubmed/21326202
• Sho. Kanzaki, et.al., Impaired vibration of auditory ossicles in osteopetrotic mice., The American journal of pathology, 2011, 178
  http://rdf.ncbi.nlm.nih.gov/pubmed/21356377
• B R. Wong, et.al., TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells., The Journal of biological chemistry, 1997, 272
  http://rdf.ncbi.nlm.nih.gov/pubmed/9312132
他4件を見る
• D M. Anderson, et.al., A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function., Nature, 1997, 390
  http://rdf.ncbi.nlm.nih.gov/pubmed/9367155
• B R. Wong, et.al., TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor., The Journal of experimental medicine, 1997, 186
  http://rdf.ncbi.nlm.nih.gov/pubmed/9396779
• H. Yasuda, et.al., Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL., Proceedings of the National Academy of Sciences of the United States of America, 1998, 95
  http://rdf.ncbi.nlm.nih.gov/pubmed/9520411
• D L. Lacey, et.al., Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation., Cell, 1998, 93
  http://rdf.ncbi.nlm.nih.gov/pubmed/9568710

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• ossification
  http://purl.obolibrary.org/obo/GO_0001503
• monocyte chemotaxis
  http://purl.obolibrary.org/obo/GO_0002548
• cytokine activity
  http://purl.obolibrary.org/obo/GO_0005125
• tumor necrosis factor receptor binding
  http://purl.obolibrary.org/obo/GO_0005164
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• extracellular region
  http://purl.obolibrary.org/obo/GO_0005576
他36件を見る
• extracellular space
  http://purl.obolibrary.org/obo/GO_0005615
• intracellular
  http://purl.obolibrary.org/obo/GO_0005622
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• plasma membrane
  http://purl.obolibrary.org/obo/GO_0005886
• immune response
  http://purl.obolibrary.org/obo/GO_0006955
• activation of JUN kinase activity
  http://purl.obolibrary.org/obo/GO_0007257
• membrane
  http://purl.obolibrary.org/obo/GO_0016020
• integral component of membrane
  http://purl.obolibrary.org/obo/GO_0016021
• cytokine-mediated signaling pathway
  http://purl.obolibrary.org/obo/GO_0019221
• cell differentiation
  http://purl.obolibrary.org/obo/GO_0030154
• osteoclast differentiation
  http://purl.obolibrary.org/obo/GO_0030316
• tumor necrosis factor receptor superfamily binding
  http://purl.obolibrary.org/obo/GO_0032813
• tumor necrosis factor-mediated signaling pathway
  http://purl.obolibrary.org/obo/GO_0033209
• mammary gland epithelial cell proliferation
  http://purl.obolibrary.org/obo/GO_0033598
• positive regulation of homotypic cell-cell adhesion
  http://purl.obolibrary.org/obo/GO_0034112
• signaling receptor activity
  http://purl.obolibrary.org/obo/GO_0038023
• cargo receptor activity
  http://purl.obolibrary.org/obo/GO_0038024
• positive regulation of phosphorylation
  http://purl.obolibrary.org/obo/GO_0042327
• positive regulation of I-kappaB kinase/NF-kappaB signaling
  http://purl.obolibrary.org/obo/GO_0043123
• bone resorption
  http://purl.obolibrary.org/obo/GO_0045453
• regulation of osteoclast differentiation
  http://purl.obolibrary.org/obo/GO_0045670
• positive regulation of osteoclast differentiation
  http://purl.obolibrary.org/obo/GO_0045672
• positive regulation of bone resorption
  http://purl.obolibrary.org/obo/GO_0045780
• lymph node development
  http://purl.obolibrary.org/obo/GO_0048535
• positive regulation of T cell activation
  http://purl.obolibrary.org/obo/GO_0050870
• positive regulation of sequence-specific DNA binding transcription factor activity
  http://purl.obolibrary.org/obo/GO_0051091
• positive regulation of NF-kappaB transcription factor activity
  http://purl.obolibrary.org/obo/GO_0051092
• protein homooligomerization
  http://purl.obolibrary.org/obo/GO_0051260
• positive regulation of corticotropin-releasing hormone secretion
  http://purl.obolibrary.org/obo/GO_0051466
• positive regulation of protein kinase B signaling
  http://purl.obolibrary.org/obo/GO_0051897
• mammary gland alveolus development
  http://purl.obolibrary.org/obo/GO_0060749
• ERK1 and ERK2 cascade
  http://purl.obolibrary.org/obo/GO_0070371
• positive regulation of fever generation by positive regulation of prostaglandin secretion
  http://purl.obolibrary.org/obo/GO_0071812
• TNFSF11-mediated signaling pathway
  http://purl.obolibrary.org/obo/GO_0071847
• positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling
  http://purl.obolibrary.org/obo/GO_0071848
• positive regulation of intracellular signal transduction
  http://purl.obolibrary.org/obo/GO_1902533

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04060
• http://www.genome.jp/dbget-bin/www_bget?map04380
• http://www.genome.jp/dbget-bin/www_bget?map05323

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Cytokine-cytokine receptor interaction
• Osteoclast differentiation
• Rheumatoid arthritis