CD16919

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD16919

CD16919

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Nr1h4

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• nuclear receptor subfamily 1, group H, member 4

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• bile acid receptor
• RXR-interacting protein 14
• farnesoid X activated receptor
• farnesoid X-activated receptor
• retinoid X receptor-interacting protein 14
• farnesol receptor HRR-1
• nuclear receptor subfamily 1, group H, member 4

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• FXR
• Rxrip14
• RIP14
• Fxr
• AI957360
• HRR1

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/20186

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• nuclear receptor subfamily 1, group H, member 4
  http://metadb.riken.jp/db/mgi_rdf/MGI:1352464

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_009108
• https://www.ncbi.nlm.nih.gov/nuccore/NM_001163700
• https://www.ncbi.nlm.nih.gov/nuccore/NM_001163504

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000047638

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.3095

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=603826

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• C A. Kozak, et.al., Genetic mapping of gene encoding the farnesoid receptor, Fxr, to mouse Chromosome 10., Mammalian genome : official journal of the International Mammalian Genome Society, 1996, 7
  http://rdf.ncbi.nlm.nih.gov/pubmed/8835541
• Mouaadh. Abdelkarim, et.al., The farnesoid X receptor regulates adipocyte differentiation and function by promoting peroxisome proliferator-activated receptor-gamma and interfering with the Wnt/beta-catenin pathways., The Journal of biological chemistry, 2010, 285
  http://rdf.ncbi.nlm.nih.gov/pubmed/20851881
• C J. Sinal, et.al., Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis., Cell, 2000, 102
  http://rdf.ncbi.nlm.nih.gov/pubmed/11030617
• F. Lammert, et.al., Chromosomal organization of candidate genes involved in cholesterol gallstone formation: a murine gallstone map., Gastroenterology, 2001, 120
  http://rdf.ncbi.nlm.nih.gov/pubmed/11208732
• Ina V. Martin, et.al., Bile acid retention and activation of endogenous hepatic farnesoid-X-receptor in the pathogenesis of fatty liver disease in ob/ob-mice., Biological chemistry, 2010, 391
  http://rdf.ncbi.nlm.nih.gov/pubmed/20868235
• Daniel R. Schmidt, et.al., AKR1B7 is induced by the farnesoid X receptor and metabolizes bile acids., The Journal of biological chemistry, 2011, 286
  http://rdf.ncbi.nlm.nih.gov/pubmed/21081494
• Sayeepriyadarshini. Anakk, et.al., Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis., The Journal of clinical investigation, 2011, 121
  http://rdf.ncbi.nlm.nih.gov/pubmed/21123943
• W. Seol, et.al., Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors., Molecular endocrinology (Baltimore, Md.), 1995, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/7760852
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• D Q. Shih, et.al., Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism., Nature genetics, 2001, 27
  http://rdf.ncbi.nlm.nih.gov/pubmed/11279518

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• steroid hormone receptor activity
  http://purl.obolibrary.org/obo/GO_0003707
• positive regulation of transcription from RNA polymerase II promoter
  http://purl.obolibrary.org/obo/GO_0045944
• cargo receptor activity
  http://purl.obolibrary.org/obo/GO_0038024
• regulation of transcription from RNA polymerase II promoter
  http://purl.obolibrary.org/obo/GO_0006357
• nucleus
  http://purl.obolibrary.org/obo/GO_0005634
• retinoid X receptor binding
  http://purl.obolibrary.org/obo/GO_0046965
• steroid hormone mediated signaling pathway
  http://purl.obolibrary.org/obo/GO_0043401
• regulation of carbohydrate metabolic process
  http://purl.obolibrary.org/obo/GO_0006109
• double-stranded DNA binding
  http://purl.obolibrary.org/obo/GO_0003690
• regulation of transcription, DNA-templated
  http://purl.obolibrary.org/obo/GO_0006355
• bile acid binding
  http://purl.obolibrary.org/obo/GO_0032052
• sequence-specific DNA binding
  http://purl.obolibrary.org/obo/GO_0043565
• thyroid hormone receptor activity
  http://purl.obolibrary.org/obo/GO_0004887
• signaling receptor activity
  http://purl.obolibrary.org/obo/GO_0038023
• intracellular receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0030522
• peptide binding
  http://purl.obolibrary.org/obo/GO_0042277
• sequence-specific DNA binding transcription factor activity
  http://purl.obolibrary.org/obo/GO_0003700
• DNA binding
  http://purl.obolibrary.org/obo/GO_0003677
• negative regulation of transcription from RNA polymerase II promoter
  http://purl.obolibrary.org/obo/GO_0000122
• transcription, DNA-templated
  http://purl.obolibrary.org/obo/GO_0006351
• zinc ion binding
  http://purl.obolibrary.org/obo/GO_0008270
• metal ion binding
  http://purl.obolibrary.org/obo/GO_0046872
• bile acid metabolic process
  http://purl.obolibrary.org/obo/GO_0008206

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04976

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Bile secretion