CD18115

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD18115

CD18115

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Abcg8

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• ATP-binding cassette, sub-family G (WHITE), member 8

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• ATP-binding cassette sub-family G member 8
• sterolin 2
• ATP-binding cassette, sub-family G (WHITE), member 8

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• sterolin-2
• AI114946
• Sterolin-2
• 1300003C16Rik

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/67470

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• ATP-binding cassette, sub-family G (WHITE), member 8
  http://metadb.riken.jp/db/mgi_rdf/MGI:1914720

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_026180

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000024254

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.26581

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=605460

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Harmen. Wiersma, et.al., Scavenger receptor class B type I mediates biliary cholesterol secretion independent of ATP-binding cassette transporter g5/g8 in mice., Hepatology (Baltimore, Md.), 2009, 50
  http://rdf.ncbi.nlm.nih.gov/pubmed/19637290
• Kangmo. Lu, et.al., Molecular cloning, genomic organization, genetic variations, and characterization of murine sterolin genes Abcg5 and Abcg8., Journal of lipid research, 2002, 43
  http://rdf.ncbi.nlm.nih.gov/pubmed/11907139
• Lily. Jakulj, et.al., Ezetimibe stimulates faecal neutral sterol excretion depending on abcg8 function in mice., FEBS letters, 2010, 584
  http://rdf.ncbi.nlm.nih.gov/pubmed/20659465
• Yuanfang. Guan, et.al., Functional genomics complements quantitative genetics in identifying disease-gene associations., PLoS computational biology, 2010, 6
  http://rdf.ncbi.nlm.nih.gov/pubmed/21085640
• K E. Berge, et.al., Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters., Science (New York, N.Y.), 2000, 290
  http://rdf.ncbi.nlm.nih.gov/pubmed/11099417
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• Joyce J. Repa, et.al., Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta., The Journal of biological chemistry, 2002, 277
  http://rdf.ncbi.nlm.nih.gov/pubmed/11901146
• Thomas H. Chase, et.al., The mouse mutation "thrombocytopenia and cardiomyopathy" (trac) disrupts Abcg5: a spontaneous single gene model for human hereditary phytosterolemia/sitosterolemia., Blood, 2010, 115
  http://rdf.ncbi.nlm.nih.gov/pubmed/19846887
• K. Lu, et.al., Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively., American journal of human genetics, 2001, 69
  http://rdf.ncbi.nlm.nih.gov/pubmed/11452359
• Alan T. Remaley, et.al., Comparative genome analysis of potential regulatory elements in the ABCG5-ABCG8 gene cluster., Biochemical and biophysical research communications, 2002, 295
  http://rdf.ncbi.nlm.nih.gov/pubmed/12150943

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• apical plasma membrane
  http://purl.obolibrary.org/obo/GO_0016324
• cholesterol efflux
  http://purl.obolibrary.org/obo/GO_0033344
• negative regulation of intestinal cholesterol absorption
  http://purl.obolibrary.org/obo/GO_0045796
• excretion
  http://purl.obolibrary.org/obo/GO_0007588
• nucleotide binding
  http://purl.obolibrary.org/obo/GO_0000166
• ATP binding
  http://purl.obolibrary.org/obo/GO_0005524
• sterol transporter activity
  http://purl.obolibrary.org/obo/GO_0015248
• negative regulation of intestinal phytosterol absorption
  http://purl.obolibrary.org/obo/GO_0010949
• transport
  http://purl.obolibrary.org/obo/GO_0006810
• intestinal cholesterol absorption
  http://purl.obolibrary.org/obo/GO_0030299
• membrane
  http://purl.obolibrary.org/obo/GO_0016020
• protein heterodimerization activity
  http://purl.obolibrary.org/obo/GO_0046982
• cholesterol homeostasis
  http://purl.obolibrary.org/obo/GO_0042632
• sterol homeostasis
  http://purl.obolibrary.org/obo/GO_0055092
• integral component of membrane
  http://purl.obolibrary.org/obo/GO_0016021
• sterol transport
  http://purl.obolibrary.org/obo/GO_0015918
• phospholipid transport
  http://purl.obolibrary.org/obo/GO_0015914
• ATPase activity
  http://purl.obolibrary.org/obo/GO_0016887
• cholesterol transporter activity
  http://purl.obolibrary.org/obo/GO_0017127

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04975
• http://www.genome.jp/dbget-bin/www_bget?map04976
• http://www.genome.jp/dbget-bin/www_bget?map02010

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• ABC transporters
• Bile secretion
• Fat digestion and absorption