CD18471

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD18471

CD18471

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Arhgef1

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• Rho guanine nucleotide exchange factor (GEF) 1

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• lymphoid blast crisis like 2
• lymphoid blast crisis-like 2
• Rho guanine nucleotide exchange factor (GEF) 1
• lbc's second cousin
• rho guanine nucleotide exchange factor 1

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• Lsc
• Lbcl2

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/16801

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• Rho guanine nucleotide exchange factor (GEF) 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1353510

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_008488
• https://www.ncbi.nlm.nih.gov/nuccore/NM_001130151
• https://www.ncbi.nlm.nih.gov/nuccore/NM_001130150
• https://www.ncbi.nlm.nih.gov/nuccore/NM_001130153
• https://www.ncbi.nlm.nih.gov/nuccore/NM_001130152

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000040940

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.3181

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=601855

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Jesus. Colino, et.al., Parameters underlying distinct T cell-dependent polysaccharide-specific IgG responses to an intact gram-positive bacterium versus a soluble conjugate vaccine., Journal of immunology (Baltimore, Md. : 1950), 2009, 183
  http://rdf.ncbi.nlm.nih.gov/pubmed/19570830
• J A. Glaven, et.al., Lfc and Lsc oncoproteins represent two new guanine nucleotide exchange factors for the Rho GTP-binding protein., The Journal of biological chemistry, 1996, 271
  http://rdf.ncbi.nlm.nih.gov/pubmed/8910315
• I P. Whitehead, et.al., Expression cloning of lsc, a novel oncogene with structural similarities to the Dbl family of guanine nucleotide exchange factors., The Journal of biological chemistry, 1996, 271
  http://rdf.ncbi.nlm.nih.gov/pubmed/8702517
• Eugen. Zizer, et.al., Loss of Lsc/p115 protein leads to neuronal hypoplasia in the esophagus and an achalasia-like phenotype in mice., Gastroenterology, 2010, 139
  http://rdf.ncbi.nlm.nih.gov/pubmed/20600037
• Zhe. Chen, et.al., Recognition of the activated states of Galpha13 by the rgRGS domain of PDZRhoGEF., Structure (London, England : 1993), 2008, 16
  http://rdf.ncbi.nlm.nih.gov/pubmed/18940608
• C C. Chu, et.al., Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis., Molecular immunology, 1998, 35
  http://rdf.ncbi.nlm.nih.gov/pubmed/9798653
• John M. Hartney, et.al., Arhgef1 regulates alpha5beta1 integrin-mediated matrix metalloproteinase expression and is required for homeostatic lung immunity., The American journal of pathology, 2010, 176
  http://rdf.ncbi.nlm.nih.gov/pubmed/20093499
• Christophe. Guilluy, et.al., The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure., Nature medicine, 2010, 16
  http://rdf.ncbi.nlm.nih.gov/pubmed/20098430
• H C. Aasheim, et.al., Characterization, expression and chromosomal localization of a human gene homologous to the mouse Lsc oncogene, with strongest expression in hematopoetic tissues., Oncogene, 1997, 14
  http://rdf.ncbi.nlm.nih.gov/pubmed/9135076
• I. Girkontaite, et.al., Lsc is required for marginal zone B cells, regulation of lymphocyte motility and immune responses., Nature immunology, 2001, 2
  http://rdf.ncbi.nlm.nih.gov/pubmed/11526402

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• GTPase activator activity
  http://purl.obolibrary.org/obo/GO_0005096
• guanyl-nucleotide exchange factor activity
  http://purl.obolibrary.org/obo/GO_0005085
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• regulation of Rho protein signal transduction
  http://purl.obolibrary.org/obo/GO_0035023
• membrane
  http://purl.obolibrary.org/obo/GO_0016020
• positive regulation of GTPase activity
  http://purl.obolibrary.org/obo/GO_0043547
• termination of G-protein coupled receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0038032
• intracellular
  http://purl.obolibrary.org/obo/GO_0005622
• Rho guanyl-nucleotide exchange factor activity
  http://purl.obolibrary.org/obo/GO_0005089
• regulation of catalytic activity
  http://purl.obolibrary.org/obo/GO_0050790
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04810
• http://www.genome.jp/dbget-bin/www_bget?map04270

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Vascular smooth muscle contraction
• Regulation of actin cytoskeleton