CD18628

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD18628

CD18628

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Grk1

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• G protein-coupled receptor kinase 1

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• G-protein receptor kinase 1
• G protein-coupled receptor kinase 1
• rhodopsin kinase

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• Rhok
• RK
• Rk
• Gprk1

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/24013

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• G protein-coupled receptor kinase 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1345146

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_011881

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000031450

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.257501

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=180381

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Ching-Kang. Chen, et.al., Background light produces a recoverin-dependent modulation of activated-rhodopsin lifetime in mouse rods., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, 30
  http://rdf.ncbi.nlm.nih.gov/pubmed/20107049
• Tiffany. Whitcomb, et.al., Effect of g protein-coupled receptor kinase 1 (Grk1) overexpression on rod photoreceptor cell viability., Investigative ophthalmology & visual science, 2010, 51
  http://rdf.ncbi.nlm.nih.gov/pubmed/19834036
• Jie. Fan, et.al., Deletion of GRK1 causes retina degeneration through a transducin-independent mechanism., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, 30
  http://rdf.ncbi.nlm.nih.gov/pubmed/20164334
• Ana. Mendez, et.al., Light-dependent translocation of arrestin in the absence of rhodopsin phosphorylation and transducin signaling., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, 23
  http://rdf.ncbi.nlm.nih.gov/pubmed/12716919
• Ekaterina S. Lobanova, et.al., Mechanistic basis for the failure of cone transducin to translocate: why cones are never blinded by light., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, 30
  http://rdf.ncbi.nlm.nih.gov/pubmed/20484624
• C K. Chen, et.al., Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase., Proceedings of the National Academy of Sciences of the United States of America, 1999, 96
  http://rdf.ncbi.nlm.nih.gov/pubmed/10097103
• A L. Lyubarsky, et.al., Mice lacking G-protein receptor kinase 1 have profoundly slowed recovery of cone-driven retinal responses., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, 20
  http://rdf.ncbi.nlm.nih.gov/pubmed/10704496
• Houbin. Zhang, et.al., Light-dependent redistribution of visual arrestins and transducin subunits in mice with defective phototransduction., Molecular vision, 2003, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/12802257
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• S. Choi, et.al., Gene expression profiles of light-induced apoptosis in arrestin/rhodopsin kinase-deficient mouse retinas., Proceedings of the National Academy of Sciences of the United States of America, 2001, 98
  http://rdf.ncbi.nlm.nih.gov/pubmed/11687607

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• transferase activity
  http://purl.obolibrary.org/obo/GO_0016740
• signaling receptor activity
  http://purl.obolibrary.org/obo/GO_0038023
• ATP binding
  http://purl.obolibrary.org/obo/GO_0005524
• protein serine/threonine kinase activity
  http://purl.obolibrary.org/obo/GO_0004674
• positive regulation of phosphorylation
  http://purl.obolibrary.org/obo/GO_0042327
• photoreceptor cell morphogenesis
  http://purl.obolibrary.org/obo/GO_0008594
• post-embryonic retina morphogenesis in camera-type eye
  http://purl.obolibrary.org/obo/GO_0060060
• apoptotic process
  http://purl.obolibrary.org/obo/GO_0006915
• kinase activity
  http://purl.obolibrary.org/obo/GO_0016301
• nucleotide binding
  http://purl.obolibrary.org/obo/GO_0000166
• regulation of rhodopsin mediated signaling pathway
  http://purl.obolibrary.org/obo/GO_0022400
• response to light stimulus
  http://purl.obolibrary.org/obo/GO_0009416
• phosphorylation
  http://purl.obolibrary.org/obo/GO_0016310
• protein autophosphorylation
  http://purl.obolibrary.org/obo/GO_0046777
• cargo receptor activity
  http://purl.obolibrary.org/obo/GO_0038024
• rhodopsin kinase activity
  http://purl.obolibrary.org/obo/GO_0050254

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04062
• http://www.genome.jp/dbget-bin/www_bget?map04744
• http://www.genome.jp/dbget-bin/www_bget?map04144

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Endocytosis
• Phototransduction
• Chemokine signaling pathway