CD18658

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD18658

CD18658

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Pcsk1

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• proprotein convertase subtilisin/kexin type 1

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• NEC 1
• furin homolog
• proprotein convertase subtilisin/kexin type 1
• propeptide-processing protease
• neuroendocrine convertase 1
• prohormone convertase 1
• proprotein convertase 1

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• Nec1
• Nec-1
• PC1
• SPC3
• prohormone convertase 1/3
• Phpp-1
• PC3

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/18548

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• proprotein convertase subtilisin/kexin type 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:97511

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_013628

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000021587

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.1333

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=162150

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• D F. Steiner, et.al., The new enzymology of precursor processing endoproteases., The Journal of biological chemistry, 1992, 267
  http://rdf.ncbi.nlm.nih.gov/pubmed/1429684
• Anne. Blanchard, et.al., Targeted production of proprotein convertase PC1 enhances mammary development and tumorigenesis in transgenic mice., Canadian journal of physiology and pharmacology, 2009, 87
  http://rdf.ncbi.nlm.nih.gov/pubmed/20052009
• Daniel. Mesnard, et.al., Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst., The Journal of cell biology, 2010, 191
  http://rdf.ncbi.nlm.nih.gov/pubmed/20876279
• K. Nakayama, et.al., Cloning and functional expression of a novel endoprotease involved in prohormone processing at dibasic sites., Journal of biochemistry, 1991, 109
  http://rdf.ncbi.nlm.nih.gov/pubmed/1657897
• Ardalan. Minokadeh, et.al., Cathepsin L participates in dynorphin production in brain cortex, illustrated by protease gene knockout and expression., Molecular and cellular neurosciences, 2010, 43
  http://rdf.ncbi.nlm.nih.gov/pubmed/19837164
• N G. Copeland, et.al., Regional localization of three convertases, PC1 (Nec-1), PC2 (Nec-2), and furin (Fur), on mouse chromosomes., Genomics, 1992, 13
  http://rdf.ncbi.nlm.nih.gov/pubmed/1354647
• Akihiko. Ozawa, et.al., Modulation of prohormone convertase 1/3 properties using site-directed mutagenesis., Endocrinology, 2010, 151
  http://rdf.ncbi.nlm.nih.gov/pubmed/20610561
• J. Korner, et.al., Isolation and functional expression of a mammalian prohormone processing enzyme, murine prohormone convertase 1., Proceedings of the National Academy of Sciences of the United States of America, 1991, 88
  http://rdf.ncbi.nlm.nih.gov/pubmed/1862107
• N G. Seidah, et.al., Chromosomal assignments of the genes for neuroendocrine convertase PC1 (NEC1) to human 5q15-21, neuroendocrine convertase PC2 (NEC2) to human 20p11.1-11.2, and furin (mouse 7[D1-E2] region)., Genomics, 1991, 11
  http://rdf.ncbi.nlm.nih.gov/pubmed/1765368
• Jonathan H. Wardman, et.al., Analysis of peptides in prohormone convertase 1/3 null mouse brain using quantitative peptidomics., Journal of neurochemistry, 2010, 114
  http://rdf.ncbi.nlm.nih.gov/pubmed/20412386

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• Golgi apparatus
  http://purl.obolibrary.org/obo/GO_0005794
• metabolic process
  http://purl.obolibrary.org/obo/GO_0008152
• insulin binding
  http://purl.obolibrary.org/obo/GO_0043559
• protein autoprocessing
  http://purl.obolibrary.org/obo/GO_0016540
• peptidase activity
  http://purl.obolibrary.org/obo/GO_0008233
• trans-Golgi network
  http://purl.obolibrary.org/obo/GO_0005802
• dendrite
  http://purl.obolibrary.org/obo/GO_0030425
• peptide biosynthetic process
  http://purl.obolibrary.org/obo/GO_0043043
• neuron projection
  http://purl.obolibrary.org/obo/GO_0043005
• endopeptidase activity
  http://purl.obolibrary.org/obo/GO_0004175
• macromolecular complex binding
  http://purl.obolibrary.org/obo/GO_0044877
• secretory granule
  http://purl.obolibrary.org/obo/GO_0030141
• protein processing
  http://purl.obolibrary.org/obo/GO_0016485
• neuronal cell body
  http://purl.obolibrary.org/obo/GO_0043025
• perinuclear region of cytoplasm
  http://purl.obolibrary.org/obo/GO_0048471
• rough endoplasmic reticulum
  http://purl.obolibrary.org/obo/GO_0005791
• cytoplasmic vesicle
  http://purl.obolibrary.org/obo/GO_0031410
• axon terminus
  http://purl.obolibrary.org/obo/GO_0043679
• chaperone binding
  http://purl.obolibrary.org/obo/GO_0051087
• proteolysis
  http://purl.obolibrary.org/obo/GO_0006508
• peptide hormone processing
  http://purl.obolibrary.org/obo/GO_0016486
• hydrolase activity
  http://purl.obolibrary.org/obo/GO_0016787
• positive regulation of protein secretion
  http://purl.obolibrary.org/obo/GO_0050714
• extracellular space
  http://purl.obolibrary.org/obo/GO_0005615
• serine-type endopeptidase activity
  http://purl.obolibrary.org/obo/GO_0004252
• serine-type peptidase activity
  http://purl.obolibrary.org/obo/GO_0008236

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName