CD18881

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD18881

CD18881

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Lmna

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• lamin A

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• lamin A
• prelamin-A/C
• lamin-A/C
• lamin C

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• Dhe
• lamin A/C

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/16905

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• lamin A
  http://metadb.riken.jp/db/mgi_rdf/MGI:96794

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_001002011
• https://www.ncbi.nlm.nih.gov/nuccore/NM_001111102
• https://www.ncbi.nlm.nih.gov/nuccore/NM_019390

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000028063

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.471227
• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.243014

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=150330

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• M. Eggert, et.al., Identification of phosphorylation sites on murine nuclear lamin C by RP-HPLC and microsequencing., FEBS letters, 1991, 292
  http://rdf.ncbi.nlm.nih.gov/pubmed/1959608
• Lidia. Hernandez, et.al., Functional coupling between the extracellular matrix and nuclear lamina by Wnt signaling in progeria., Developmental cell, 2010, 19
  http://rdf.ncbi.nlm.nih.gov/pubmed/20833363
• W. Riedel, et.al., Nucleotide sequence of the full-length mouse lamin C cDNA and its deduced amino-acid sequence., Biochimica et biophysica acta, 1989, 1008
  http://rdf.ncbi.nlm.nih.gov/pubmed/2719959
• N. Nakajima, et.al., Genomic structure of the mouse A-type lamin gene locus encoding somatic and germ cell-specific lamins., FEBS letters, 1995, 365
  http://rdf.ncbi.nlm.nih.gov/pubmed/7781761
• Dan. Lu, et.al., LMNA E82K mutation activates FAS and mitochondrial pathways of apoptosis in heart tissue specific transgenic mice., PloS one, 2010, 5
  http://rdf.ncbi.nlm.nih.gov/pubmed/21151901
• S B. Moss, et.al., The differential expression of lamin epitopes during mouse spermatogenesis., Molecular reproduction and development, 1993, 34
  http://rdf.ncbi.nlm.nih.gov/pubmed/7680212
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• Eric S. Folker, et.al., Lamin A variants that cause striated muscle disease are defective in anchoring transmembrane actin-associated nuclear lines for nuclear movement., Proceedings of the National Academy of Sciences of the United States of America, 2011, 108
  http://rdf.ncbi.nlm.nih.gov/pubmed/21173262
• Shao H. Yang, et.al., Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin., Human molecular genetics, 2011, 20
  http://rdf.ncbi.nlm.nih.gov/pubmed/21088111
• K. Weber, et.al., Maturation of nuclear lamin A involves a specific carboxy-terminal trimming, which removes the polyisoprenylation site from the precursor; implications for the structure of the nuclear lamina., FEBS letters, 1989, 257
  http://rdf.ncbi.nlm.nih.gov/pubmed/2583287

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• protein localization to nucleus
  http://purl.obolibrary.org/obo/GO_0034504
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• intracellular
  http://purl.obolibrary.org/obo/GO_0005622
• regulation of apoptotic process
  http://purl.obolibrary.org/obo/GO_0042981
• nuclear matrix
  http://purl.obolibrary.org/obo/GO_0016363
• positive regulation of cell aging
  http://purl.obolibrary.org/obo/GO_0090343
• establishment of cell polarity
  http://purl.obolibrary.org/obo/GO_0030010
• establishment or maintenance of microtubule cytoskeleton polarity
  http://purl.obolibrary.org/obo/GO_0030951
• ventricular cardiac muscle cell development
  http://purl.obolibrary.org/obo/GO_0055015
• insoluble fraction
  http://purl.obolibrary.org/obo/GO_0005626
• nucleus
  http://purl.obolibrary.org/obo/GO_0005634
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• regulation of cell migration
  http://purl.obolibrary.org/obo/GO_0030334
• intermediate filament
  http://purl.obolibrary.org/obo/GO_0005882
• nucleus organization
  http://purl.obolibrary.org/obo/GO_0006997
• perinuclear region of cytoplasm
  http://purl.obolibrary.org/obo/GO_0048471
• structural molecule activity
  http://purl.obolibrary.org/obo/GO_0005198
• muscle organ development
  http://purl.obolibrary.org/obo/GO_0007517
• nuclear envelope
  http://purl.obolibrary.org/obo/GO_0005635
• lamin filament
  http://purl.obolibrary.org/obo/GO_0005638
• nuclear envelope organization
  http://purl.obolibrary.org/obo/GO_0006998

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map05410
• http://www.genome.jp/dbget-bin/www_bget?map05414
• http://www.genome.jp/dbget-bin/www_bget?map05412

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Arrhythmogenic right ventricular cardiomyopathy (ARVC)
• Hypertrophic cardiomyopathy (HCM)
• Dilated cardiomyopathy