CD19276

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD19276

CD19276

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Pdx1

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• pancreatic and duodenal homeobox 1

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• pancreatic and duodenal homeobox gene 1
• pancreas/duodenum homeobox protein 1
• insulin promoter factor 1, homeodomain transcription factor
• pancreatic and duodenal homeobox 1
• islet/duodenum homeobox 1
• somatostatin-transactivating factor 1

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• IDX-1
• Ipf1
• STF-1
• pdx-1
• Mody4
• IPF-1

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/18609

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• pancreatic and duodenal homeobox 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:102851

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_008814

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000029644

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.389714

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=600733

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Kei. Fujimoto, et.al., Loss of Nix in Pdx1-deficient mice prevents apoptotic and necrotic β cell death and diabetes., The Journal of clinical investigation, 2010, 120
  http://rdf.ncbi.nlm.nih.gov/pubmed/20978346
• Jennifer L. Plank, et.al., Influence and timing of arrival of murine neural crest on pancreatic beta cell development and maturation., Developmental biology, 2011, 349
  http://rdf.ncbi.nlm.nih.gov/pubmed/21081123
• F T. Fiedorek, et.al., Mapping of the insulin promoter factor 1 gene (Ipf1) to distal mouse chromosome 5., Genomics, 1995, 28
  http://rdf.ncbi.nlm.nih.gov/pubmed/7490099
• Alethia. Villasenor, et.al., Epithelial dynamics of pancreatic branching morphogenesis., Development (Cambridge, England), 2010, 137
  http://rdf.ncbi.nlm.nih.gov/pubmed/21098570
• Pawel K. Mazur, et.al., Identification of epidermal Pdx1 expression discloses different roles of Notch1 and Notch2 in murine Kras(G12D)-induced skin carcinogenesis in vivo., PloS one, 2010, 5
  http://rdf.ncbi.nlm.nih.gov/pubmed/21042537
• J. Leonard, et.al., Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells., Molecular endocrinology (Baltimore, Md.), 1993, 7
  http://rdf.ncbi.nlm.nih.gov/pubmed/7505393
• J. Jonsson, et.al., Insulin-promoter-factor 1 is required for pancreas development in mice., Nature, 1994, 371
  http://rdf.ncbi.nlm.nih.gov/pubmed/7935793
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• Y. Guz, et.al., Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny., Development (Cambridge, England), 1995, 121
  http://rdf.ncbi.nlm.nih.gov/pubmed/7867492
• H. Ohlsson, et.al., IPF1, a homeodomain-containing transactivator of the insulin gene., The EMBO journal, 1993, 12
  http://rdf.ncbi.nlm.nih.gov/pubmed/7901001

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• positive regulation of cell proliferation
  http://purl.obolibrary.org/obo/GO_0008284
• positive regulation of cell death
  http://purl.obolibrary.org/obo/GO_0010942
• transcription from RNA polymerase II promoter
  http://purl.obolibrary.org/obo/GO_0006366
• sequence-specific DNA binding transcription factor activity
  http://purl.obolibrary.org/obo/GO_0003700
• macromolecular complex binding
  http://purl.obolibrary.org/obo/GO_0044877
• morphogenesis of embryonic epithelium
  http://purl.obolibrary.org/obo/GO_0016331
• chromatin binding
  http://purl.obolibrary.org/obo/GO_0003682
• nucleus
  http://purl.obolibrary.org/obo/GO_0005634
• negative regulation of transcription from RNA polymerase II promoter
  http://purl.obolibrary.org/obo/GO_0000122
• nitric oxide mediated signal transduction
  http://purl.obolibrary.org/obo/GO_0007263
• exocrine pancreas development
  http://purl.obolibrary.org/obo/GO_0031017
• glucose metabolic process
  http://purl.obolibrary.org/obo/GO_0006006
• core promoter sequence-specific DNA binding
  http://purl.obolibrary.org/obo/GO_0001046
• positive regulation of transcription, DNA-templated
  http://purl.obolibrary.org/obo/GO_0045893
• negative regulation of cell proliferation
  http://purl.obolibrary.org/obo/GO_0008285
• protein heterodimerization activity
  http://purl.obolibrary.org/obo/GO_0046982
• regulation of transcription from RNA polymerase II promoter
  http://purl.obolibrary.org/obo/GO_0006357
• digestive tract development
  http://purl.obolibrary.org/obo/GO_0048565
• pancreas development
  http://purl.obolibrary.org/obo/GO_0031016
• response to glucose
  http://purl.obolibrary.org/obo/GO_0009749
• insulin secretion
  http://purl.obolibrary.org/obo/GO_0030073
• positive regulation of DNA binding
  http://purl.obolibrary.org/obo/GO_0043388
• sequence-specific DNA binding
  http://purl.obolibrary.org/obo/GO_0043565
• positive regulation of transcription from RNA polymerase II promoter
  http://purl.obolibrary.org/obo/GO_0045944
• liver development
  http://purl.obolibrary.org/obo/GO_0001889
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• endocrine pancreas development
  http://purl.obolibrary.org/obo/GO_0031018
• type B pancreatic cell differentiation
  http://purl.obolibrary.org/obo/GO_0003309
• transcription factor binding
  http://purl.obolibrary.org/obo/GO_0008134
• detection of glucose
  http://purl.obolibrary.org/obo/GO_0051594
• RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
  http://purl.obolibrary.org/obo/GO_0003705
• intracellular part
  http://purl.obolibrary.org/obo/GO_0044424
• regulation of transcription, DNA-templated
  http://purl.obolibrary.org/obo/GO_0006355
• cell differentiation
  http://purl.obolibrary.org/obo/GO_0030154
• DNA binding
  http://purl.obolibrary.org/obo/GO_0003677
• regulation of cell proliferation
  http://purl.obolibrary.org/obo/GO_0042127
• transcription, DNA-templated
  http://purl.obolibrary.org/obo/GO_0006351
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• smoothened signaling pathway
  http://purl.obolibrary.org/obo/GO_0007224
• stem cell differentiation
  http://purl.obolibrary.org/obo/GO_0048863
• negative regulation of transcription, DNA-templated
  http://purl.obolibrary.org/obo/GO_0045892
• glucose homeostasis
  http://purl.obolibrary.org/obo/GO_0042593
• positive regulation of insulin secretion
  http://purl.obolibrary.org/obo/GO_0032024

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04930
• http://www.genome.jp/dbget-bin/www_bget?map04950

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Maturity onset diabetes of the young
• Type II diabetes mellitus