CD20712

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD20712

CD20712

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Hpd

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• 4-hydroxyphenylpyruvic acid dioxygenase

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• 4-hydroxyphenylpyruvic acid oxidase
• f Alloantigen
• f protein
• 4-hydroxyphenylpyruvate dioxygenase
• 4HPPD
• 4-hydroxyphenylpyruvic acid dioxygenase
• HPPDase
• F liver antigen

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• Laf
• Hppd
• Fla
• Flp

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/15445

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• 4-hydroxyphenylpyruvic acid dioxygenase
  http://metadb.riken.jp/db/mgi_rdf/MGI:96213

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_008277

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000029445

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.439709

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=609695

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• J P. Schofield, et.al., Sequences of the mouse F protein alleles and identification of a T cell epitope., European journal of immunology, 1991, 21
  http://rdf.ncbi.nlm.nih.gov/pubmed/1709870
• U. Rüetschi, et.al., Mutations in the 4-hydroxyphenylpyruvate dioxygenase gene (HPD) in patients with tyrosinemia type III., Human genetics, 2000, 106
  http://rdf.ncbi.nlm.nih.gov/pubmed/10942115
• F. Endo, et.al., A murine model for type III tyrosinemia: lack of immunologically detectable 4-hydroxyphenylpyruvic acid dioxygenase enzyme protein in a novel mouse strain with hypertyrosinemia., American journal of human genetics, 1991, 48
  http://rdf.ncbi.nlm.nih.gov/pubmed/2014797
• M S. Sun, et.al., A mouse model of renal tubular injury of tyrosinemia type 1: development of de Toni Fanconi syndrome and apoptosis of renal tubular cells in Fah/Hpd double mutant mice., Journal of the American Society of Nephrology : JASN, 2000, 11
  http://rdf.ncbi.nlm.nih.gov/pubmed/10665936
• C J. Kuo, et.al., Molecular cloning, functional expression, and chromosomal localization of mouse hepatocyte nuclear factor 1., Proceedings of the National Academy of Sciences of the United States of America, 1990, 87
  http://rdf.ncbi.nlm.nih.gov/pubmed/2263635
• Y. Suzuki, et.al., A novel therapeutic trial of homogentisic aciduria in a murine model of alkaptonuria., Journal of human genetics, 1999, 44
  http://rdf.ncbi.nlm.nih.gov/pubmed/10083729
• D P. Lane, et.al., Inhibition of lymphocyte proliferation by murine liver-specific F antigen., Transplantation proceedings, 1977, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/867484
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• Yasuhiko. Tanaka, et.al., Gene expression profiles of homogentisate-treated Fah-/- Hpd-/-mice using DNA microarrays., Molecular genetics and metabolism, 2006, 89
  http://rdf.ncbi.nlm.nih.gov/pubmed/16899383
• S S. Teuber, et.al., The identification and cloning of the murine genes encoding the liver specific F alloantigens., Journal of autoimmunity, 1991, 4
  http://rdf.ncbi.nlm.nih.gov/pubmed/1667467

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• Golgi apparatus
  http://purl.obolibrary.org/obo/GO_0005794
• oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
  http://purl.obolibrary.org/obo/GO_0016701
• aromatic amino acid family metabolic process
  http://purl.obolibrary.org/obo/GO_0009072
• endoplasmic reticulum
  http://purl.obolibrary.org/obo/GO_0005783
• L-phenylalanine catabolic process
  http://purl.obolibrary.org/obo/GO_0006559
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• oxidoreductase activity
  http://purl.obolibrary.org/obo/GO_0016491
• quercetin 2,3-dioxygenase activity
  http://purl.obolibrary.org/obo/GO_0008127
• membrane
  http://purl.obolibrary.org/obo/GO_0016020
• oxidation-reduction process
  http://purl.obolibrary.org/obo/GO_0055114
• metal ion binding
  http://purl.obolibrary.org/obo/GO_0046872
• endoplasmic reticulum membrane
  http://purl.obolibrary.org/obo/GO_0005789
• oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
  http://purl.obolibrary.org/obo/GO_0016702
• tyrosine catabolic process
  http://purl.obolibrary.org/obo/GO_0006572
• Golgi membrane
  http://purl.obolibrary.org/obo/GO_0000139
• 4-hydroxyphenylpyruvate dioxygenase activity
  http://purl.obolibrary.org/obo/GO_0003868

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map01100
• http://www.genome.jp/dbget-bin/www_bget?map00130
• http://www.genome.jp/dbget-bin/www_bget?map00350
• http://www.genome.jp/dbget-bin/www_bget?map00360

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Phenylalanine metabolism
• Tyrosine metabolism
• Ubiquinone and other terpenoid-quinone biosynthesis
• Metabolic pathways