CD21770

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD21770

CD21770

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Icosl

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• icos ligand

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• B7 homolog 2
• B7-related protein 1
• ICOS ligand
• icos ligand
• B7-like protein Gl50

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• B7h
• BG071784
• LICOS
• Ly115l
• mKIAA0653
• B7-H2
• GL50-B
• B7RP-1
• ICOS-L
• GI50
• GL50
• AU044799
• Icoslg

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/50723

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• icos ligand
  http://metadb.riken.jp/db/mgi_rdf/MGI:1354701

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_015790

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000000732

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.17819

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=605717

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• V. Ling, et.al., Cutting edge: identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor., Journal of immunology (Baltimore, Md. : 1950), 2000, 164
  http://rdf.ncbi.nlm.nih.gov/pubmed/10657606
• Bryan S. Clay, et.al., Inducible costimulator expression regulates the magnitude of Th2-mediated airway inflammation by regulating the number of Th2 cells., PloS one, 2009, 4
  http://rdf.ncbi.nlm.nih.gov/pubmed/19888475
• M M. Swallow, et.al., B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFalpha., Immunity, 1999, 11
  http://rdf.ncbi.nlm.nih.gov/pubmed/10549624
• S K. Yoshinaga, et.al., T-cell co-stimulation through B7RP-1 and ICOS., Nature, 1999, 402
  http://rdf.ncbi.nlm.nih.gov/pubmed/10617205
• Nicolas. Prevot, et.al., Abrogation of ICOS/ICOS ligand costimulation in NOD mice results in autoimmune deviation toward the neuromuscular system., European journal of immunology, 2010, 40
  http://rdf.ncbi.nlm.nih.gov/pubmed/20544729
• H W. Mages, et.al., Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand., European journal of immunology, 2000, 30
  http://rdf.ncbi.nlm.nih.gov/pubmed/10760791
• Tomohiro. Fukaya, et.al., Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance., Blood, 2010, 116
  http://rdf.ncbi.nlm.nih.gov/pubmed/20574047
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• Kamran. Kadkhoda, et.al., Th1 cytokine responses fail to effectively control Chlamydia lung infection in ICOS ligand knockout mice., Journal of immunology (Baltimore, Md. : 1950), 2010, 184
  http://rdf.ncbi.nlm.nih.gov/pubmed/20190137
• G J. Freeman, et.al., Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation., The Journal of experimental medicine, 2000, 192
  http://rdf.ncbi.nlm.nih.gov/pubmed/11015443

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• isotype switching
  http://purl.obolibrary.org/obo/GO_0045190
• B cell activation
  http://purl.obolibrary.org/obo/GO_0042113
• external side of plasma membrane
  http://purl.obolibrary.org/obo/GO_0009897
• signal transduction
  http://purl.obolibrary.org/obo/GO_0007165
• integral component of plasma membrane
  http://purl.obolibrary.org/obo/GO_0005887
• receptor binding
  http://purl.obolibrary.org/obo/GO_0005102
• T cell activation
  http://purl.obolibrary.org/obo/GO_0042110
• integral component of membrane
  http://purl.obolibrary.org/obo/GO_0016021
• positive regulation of interleukin-4 biosynthetic process
  http://purl.obolibrary.org/obo/GO_0045404
• membrane
  http://purl.obolibrary.org/obo/GO_0016020
• positive regulation of activated T cell proliferation
  http://purl.obolibrary.org/obo/GO_0042104
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04514
• http://www.genome.jp/dbget-bin/www_bget?map04672

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Cell adhesion molecules (CAMs)
• Intestinal immune network for IgA production