CD21873

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD21873

CD21873

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Ikbkb

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• inhibitor of kappaB kinase beta

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• I-kappa-B-kinase beta
• inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
• nuclear factor NF-kappa-B inhibitor kinase beta
• IKK-B
• inhibitor of kappaB kinase beta
• I-kappa-B kinase 2
• NFKBIKB
• inhibitor of nuclear factor kappa-B kinase subunit beta

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• IKKbeta
• IKK[b]
• AI132552
• IKK-2
• IKK2
• IKK-beta

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/16150

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• inhibitor of kappaB kinase beta
  http://metadb.riken.jp/db/mgi_rdf/MGI:1338071

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_010546
• https://www.ncbi.nlm.nih.gov/nuccore/NM_001159774

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000031537

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.277886

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=603258

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• S. Nemoto, et.al., Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase., Molecular and cellular biology, 1998, 18
  http://rdf.ncbi.nlm.nih.gov/pubmed/9819420
• Ashley. Wysong, et.al., NF-κB inhibition protects against tumor-induced cardiac atrophy in vivo., The American journal of pathology, 2011, 178
  http://rdf.ncbi.nlm.nih.gov/pubmed/21356358
• Valere. Busuttil, et.al., NF-kappaB inhibits T-cell activation-induced, p73-dependent cell death by induction of MDM2., Proceedings of the National Academy of Sciences of the United States of America, 2010, 107
  http://rdf.ncbi.nlm.nih.gov/pubmed/20921405
• Li-Chung. Hsu, et.al., IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKβ., Nature immunology, 2011, 12
  http://rdf.ncbi.nlm.nih.gov/pubmed/21170027
• Gianluca. Grassia, et.al., The I{kappa}B kinase inhibitor nuclear factor-{kappa}B essential modulator-binding domain peptide for inhibition of injury-induced neointimal formation., Arteriosclerosis, thrombosis, and vascular biology, 2010, 30
  http://rdf.ncbi.nlm.nih.gov/pubmed/20930169
• S. Ghosh, et.al., NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses., Annual review of immunology, 1998, 16
  http://rdf.ncbi.nlm.nih.gov/pubmed/9597130
• I M. Verma, et.al., Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation., Genes & development, 1995, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/7590248
• H. Nakano, et.al., Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1., Proceedings of the National Academy of Sciences of the United States of America, 1998, 95
  http://rdf.ncbi.nlm.nih.gov/pubmed/9520401
• M C. Hu, et.al., IkappaB kinase-alpha and -beta genes are coexpressed in adult and embryonic tissues but localized to different human chromosomes., Gene, 1998, 222
  http://rdf.ncbi.nlm.nih.gov/pubmed/9813230
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• cytoplasmic side of plasma membrane
  http://purl.obolibrary.org/obo/GO_0009898
• I-kappaB phosphorylation
  http://purl.obolibrary.org/obo/GO_0007252
• CD40 receptor complex
  http://purl.obolibrary.org/obo/GO_0035631
• nucleus
  http://purl.obolibrary.org/obo/GO_0005634
• membrane
  http://purl.obolibrary.org/obo/GO_0016020
• receptor signaling protein serine/threonine kinase activity
  http://purl.obolibrary.org/obo/GO_0004702
• phosphorylation
  http://purl.obolibrary.org/obo/GO_0016310
• nucleotide binding
  http://purl.obolibrary.org/obo/GO_0000166
• B cell homeostasis
  http://purl.obolibrary.org/obo/GO_0001782
• regulation of I-kappaB kinase/NF-kappaB signaling
  http://purl.obolibrary.org/obo/GO_0043122
• IkappaB kinase activity
  http://purl.obolibrary.org/obo/GO_0008384
• protein heterodimerization activity
  http://purl.obolibrary.org/obo/GO_0046982
• transferase activity, transferring phosphorus-containing groups
  http://purl.obolibrary.org/obo/GO_0016772
• IkappaB kinase complex
  http://purl.obolibrary.org/obo/GO_0008385
• protein serine/threonine kinase activity
  http://purl.obolibrary.org/obo/GO_0004674
• positive regulation of NF-kappaB transcription factor activity
  http://purl.obolibrary.org/obo/GO_0051092
• transferase activity
  http://purl.obolibrary.org/obo/GO_0016740
• protein phosphorylation
  http://purl.obolibrary.org/obo/GO_0006468
• kinase activity
  http://purl.obolibrary.org/obo/GO_0016301
• protein kinase activity
  http://purl.obolibrary.org/obo/GO_0004672
• microsome
  http://purl.obolibrary.org/obo/GO_0005792
• ATP binding
  http://purl.obolibrary.org/obo/GO_0005524
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map05164
• http://www.genome.jp/dbget-bin/www_bget?map04621
• http://www.genome.jp/dbget-bin/www_bget?map05222
• http://www.genome.jp/dbget-bin/www_bget?map04920
• http://www.genome.jp/dbget-bin/www_bget?map04623
• http://www.genome.jp/dbget-bin/www_bget?map04662
• http://www.genome.jp/dbget-bin/www_bget?map05215
• http://www.genome.jp/dbget-bin/www_bget?map05160
• http://www.genome.jp/dbget-bin/www_bget?map04722
• http://www.genome.jp/dbget-bin/www_bget?map05220
• http://www.genome.jp/dbget-bin/www_bget?map04930
• http://www.genome.jp/dbget-bin/www_bget?map04380
• http://www.genome.jp/dbget-bin/www_bget?map05142
• http://www.genome.jp/dbget-bin/www_bget?map04660
• http://www.genome.jp/dbget-bin/www_bget?map05200
• http://www.genome.jp/dbget-bin/www_bget?map05166
• http://www.genome.jp/dbget-bin/www_bget?map04910
• http://www.genome.jp/dbget-bin/www_bget?map05212
• http://www.genome.jp/dbget-bin/www_bget?map04620
• http://www.genome.jp/dbget-bin/www_bget?map05145
• http://www.genome.jp/dbget-bin/www_bget?map04210
• http://www.genome.jp/dbget-bin/www_bget?map05221
• http://www.genome.jp/dbget-bin/www_bget?map04062
• http://www.genome.jp/dbget-bin/www_bget?map04622
• http://www.genome.jp/dbget-bin/www_bget?map04010

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• RIG-I-like receptor signaling pathway
• Apoptosis
• Influenza A
• Acute myeloid leukemia
• Pathways in cancer
• Adipocytokine signaling pathway
• Insulin signaling pathway
• T cell receptor signaling pathway
• Chagas disease (American trypanosomiasis)
• Toll-like receptor signaling pathway
• NOD-like receptor signaling pathway
• HTLV-I infection
• Osteoclast differentiation
• Neurotrophin signaling pathway
• MAPK signaling pathway
• Type II diabetes mellitus
• Toxoplasmosis
• Cytosolic DNA-sensing pathway
• Pancreatic cancer
• Chemokine signaling pathway
• Chronic myeloid leukemia
• B cell receptor signaling pathway
• Prostate cancer
• Hepatitis C
• Small cell lung cancer