CD21936

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD21936

CD21936

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Cyb5r4

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• cytochrome b5 reductase 4

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• flavohemoprotein b5/b5R
• N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein
• cytochrome b-type NAD(P)H oxidoreductase
• cb5/cb5R
• NADPH cytochrome B5 oxidoreductase
• cytochrome b5 reductase 4

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• Ncb5or
• B5+B5R
• C79736
• 2810034J18Rik
• b5b5r
• Cb5cb5r
• b5/b5r

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/266690

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• cytochrome b5 reductase 4
  http://metadb.riken.jp/db/mgi_rdf/MGI:2386848

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_024195

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000032872

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.30166

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=608343

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Kensuke. Oikawa, et.al., Neuronal calcium sensor protein visinin-like protein-3 interacts with microsomal cytochrome b5 in a Ca2+-dependent manner., The Journal of biological chemistry, 2004, 279
  http://rdf.ncbi.nlm.nih.gov/pubmed/14739275
• Yongzhao. Zhang, et.al., The flavoheme reductase Ncb5or protects cells against endoplasmic reticulum stress-induced lipotoxicity., Journal of lipid research, 2010, 51
  http://rdf.ncbi.nlm.nih.gov/pubmed/19609006
• Bin. Deng, et.al., Study of the individual cytochrome b5 and cytochrome b5 reductase domains of Ncb5or reveals a unique heme pocket and a possible role of the CS domain., The Journal of biological chemistry, 2010, 285
  http://rdf.ncbi.nlm.nih.gov/pubmed/20630863
• H. Zhu, et.al., Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells., Proceedings of the National Academy of Sciences of the United States of America, 1999, 96
  http://rdf.ncbi.nlm.nih.gov/pubmed/10611283
• Benjamin J. Curry, et.al., Identification and characterization of a novel splice variant of mouse and rat cytochrome b5/cytochrome b5 reductase., Genomics, 2004, 83
  http://rdf.ncbi.nlm.nih.gov/pubmed/14962668
• Kevin. Larade, et.al., The reductase NCB5OR is responsive to the redox status in beta-cells and is not involved in the ER stress response., The Biochemical journal, 2007, 404
  http://rdf.ncbi.nlm.nih.gov/pubmed/17343567
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• Hao. Zhu, et.al., NCB5OR is a novel soluble NAD(P)H reductase localized in the endoplasmic reticulum., The Journal of biological chemistry, 2004, 279
  http://rdf.ncbi.nlm.nih.gov/pubmed/15131110
• Kevin. Larade, et.al., Loss of Ncb5or results in impaired fatty acid desaturation, lipoatrophy, and diabetes., The Journal of biological chemistry, 2008, 283
  http://rdf.ncbi.nlm.nih.gov/pubmed/18682384
• C Ainsley. Davis, et.al., Heterologous expression of an endogenous rat cytochrome b(5)/cytochrome b(5) reductase fusion protein: identification of histidines 62 and 85 as the heme axial ligands., Archives of biochemistry and biophysics, 2002, 400
  http://rdf.ncbi.nlm.nih.gov/pubmed/11913972

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• oxidoreductase activity
  http://purl.obolibrary.org/obo/GO_0016491
• insulin secretion
  http://purl.obolibrary.org/obo/GO_0030073
• perinuclear region of cytoplasm
  http://purl.obolibrary.org/obo/GO_0048471
• NADP metabolic process
  http://purl.obolibrary.org/obo/GO_0006739
• NADPH-hemoprotein reductase activity
  http://purl.obolibrary.org/obo/GO_0003958
• generation of precursor metabolites and energy
  http://purl.obolibrary.org/obo/GO_0006091
• endoplasmic reticulum
  http://purl.obolibrary.org/obo/GO_0005783
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• oxidation-reduction process
  http://purl.obolibrary.org/obo/GO_0055114
• flavin adenine dinucleotide binding
  http://purl.obolibrary.org/obo/GO_0050660
• cytochrome-b5 reductase activity, acting on NADPH
  http://purl.obolibrary.org/obo/GO_0090523
• oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor
  http://purl.obolibrary.org/obo/GO_0016653
• glucose homeostasis
  http://purl.obolibrary.org/obo/GO_0042593
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• cell
  http://purl.obolibrary.org/obo/GO_0005623
• NAD(P)H oxidase activity
  http://purl.obolibrary.org/obo/GO_0016174
• cell development
  http://purl.obolibrary.org/obo/GO_0048468
• heme binding
  http://purl.obolibrary.org/obo/GO_0020037
• response to antibiotic
  http://purl.obolibrary.org/obo/GO_0046677
• metal ion binding
  http://purl.obolibrary.org/obo/GO_0046872
• heme metabolic process
  http://purl.obolibrary.org/obo/GO_0042168
• superoxide metabolic process
  http://purl.obolibrary.org/obo/GO_0006801

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName