CD28298

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD28298

CD28298

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Opa1

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• optic atrophy 1 homolog (human)

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• optic atrophy 1 homolog (human)
• dynamin-like 120 kDa protein, mitochondrial
• largeG
• large GTP-binding protein
• optic atrophy protein 1 homolog

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• mKIAA0567
• AI225888
• 1200011N24Rik
• lilr3
• AI847218

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/74143

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• OPA1, mitochondrial dynamin like GTPase
  http://metadb.riken.jp/db/mgi_rdf/MGI:1921393

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_133752
• https://www.ncbi.nlm.nih.gov/nuccore/NM_001199177

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000038084

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.274285

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=605290

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Takumi. Misaka, et.al., Primary structure of a dynamin-related mouse mitochondrial GTPase and its distribution in brain, subcellular localization, and effect on mitochondrial morphology., The Journal of biological chemistry, 2002, 277
  http://rdf.ncbi.nlm.nih.gov/pubmed/11847212
• Vamsi K. Mootha, et.al., Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria., Cell, 2003, 115
  http://rdf.ncbi.nlm.nih.gov/pubmed/14651853
• Won-Kyu. Ju, et.al., Increased optic atrophy type 1 expression protects retinal ganglion cells in a mouse model of glaucoma., Molecular vision, 2010, 16
  http://rdf.ncbi.nlm.nih.gov/pubmed/20664796
• Pete A. Williams, et.al., Opa1 deficiency in a mouse model of dominant optic atrophy leads to retinal ganglion cell dendropathy., Brain : a journal of neurology, 2010, 133
  http://rdf.ncbi.nlm.nih.gov/pubmed/20817698
• Arezu. Jahani-Asl, et.al., The mitochondrial inner membrane GTPase, optic atrophy 1 (Opa1), restores mitochondrial morphology and promotes neuronal survival following excitotoxicity., The Journal of biological chemistry, 2011, 286
  http://rdf.ncbi.nlm.nih.gov/pubmed/21041314
• Vasudheva Reddy. Akepati, et.al., Characterization of OPA1 isoforms isolated from mouse tissues., Journal of neurochemistry, 2008, 106
  http://rdf.ncbi.nlm.nih.gov/pubmed/18419770
• Sandrine. Da Cruz, et.al., Proteomic analysis of the mouse liver mitochondrial inner membrane., The Journal of biological chemistry, 2003, 278
  http://rdf.ncbi.nlm.nih.gov/pubmed/12865426
• Cécile. Delettre, et.al., Gene structure and chromosomal localization of mouse Opa1 : its exclusion from the Bst locus., BMC genetics, 2003, 4
  http://rdf.ncbi.nlm.nih.gov/pubmed/12735796
• Billie A. Moore, et.al., Mitochondrial retention of Opa1 is required for mouse embryogenesis., Mammalian genome : official journal of the International Mammalian Genome Society, 2010, 21
  http://rdf.ncbi.nlm.nih.gov/pubmed/20652258
• Marcel V. Alavi, et.al., A splice site mutation in the murine Opa1 gene features pathology of autosomal dominant optic atrophy., Brain : a journal of neurology, 2007, 130
  http://rdf.ncbi.nlm.nih.gov/pubmed/17314202

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• mitochondrial outer membrane
  http://purl.obolibrary.org/obo/GO_0005741
• nucleotide binding
  http://purl.obolibrary.org/obo/GO_0000166
• integral component of membrane
  http://purl.obolibrary.org/obo/GO_0016021
• visual perception
  http://purl.obolibrary.org/obo/GO_0007601
• mitochondrial fusion
  http://purl.obolibrary.org/obo/GO_0008053
• mitochondrion organization
  http://purl.obolibrary.org/obo/GO_0007005
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• mitochondrial intermembrane space
  http://purl.obolibrary.org/obo/GO_0005758
• apoptotic process
  http://purl.obolibrary.org/obo/GO_0006915
• membrane
  http://purl.obolibrary.org/obo/GO_0016020
• mitochondrial inner membrane
  http://purl.obolibrary.org/obo/GO_0005743
• mitochondrion
  http://purl.obolibrary.org/obo/GO_0005739
• response to stimulus
  http://purl.obolibrary.org/obo/GO_0050896
• GTPase activity
  http://purl.obolibrary.org/obo/GO_0003924
• mitochondrial crista
  http://purl.obolibrary.org/obo/GO_0030061
• positive regulation of anti-apoptosis
  http://purl.obolibrary.org/obo/GO_0045768
• GTP binding
  http://purl.obolibrary.org/obo/GO_0005525
• inner mitochondrial membrane organization
  http://purl.obolibrary.org/obo/GO_0007007
• neural tube closure
  http://purl.obolibrary.org/obo/GO_0001843
• dendrite
  http://purl.obolibrary.org/obo/GO_0030425

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName