CD28579

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD28579

CD28579

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Cox10

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast)

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• protoheme IX farnesyltransferase, mitochondrial
• heme O synthase
• COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast)

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• AU042636
• RP23-78H18.1
• 2410004F01Rik

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/70383

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• cytochrome c oxidase assembly protein 10
  http://metadb.riken.jp/db/mgi_rdf/MGI:1917633

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_178379

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000042148

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.340211

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=602125

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• David J. Pagliarini, et.al., A mitochondrial protein compendium elucidates complex I disease biology., Cell, 2008, 134
  http://rdf.ncbi.nlm.nih.gov/pubmed/18614015
• Tina. Wenz, et.al., Activation of the PPAR/PGC-1alpha pathway prevents a bioenergetic deficit and effectively improves a mitochondrial myopathy phenotype., Cell metabolism, 2008, 8
  http://rdf.ncbi.nlm.nih.gov/pubmed/18762025
• Uma D. Vempati, et.al., Role of cytochrome C in apoptosis: increased sensitivity to tumor necrosis factor alpha is associated with respiratory defects but not with lack of cytochrome C release., Molecular and cellular biology, 2007, 27
  http://rdf.ncbi.nlm.nih.gov/pubmed/17210651
• Henna. Tyynismaa, et.al., Mitochondrial myopathy induces a starvation-like response., Human molecular genetics, 2010, 19
  http://rdf.ncbi.nlm.nih.gov/pubmed/20656789
• Francisca. Diaz, et.al., Mice lacking COX10 in skeletal muscle recapitulate the phenotype of progressive mitochondrial myopathies associated with cytochrome c oxidase deficiency., Human molecular genetics, 2005, 14
  http://rdf.ncbi.nlm.nih.gov/pubmed/16103131
• Susan. Magdaleno, et.al., BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system., PLoS biology, 2006, 4
  http://rdf.ncbi.nlm.nih.gov/pubmed/16602821
• Francisca. Diaz, et.al., Cytochrome c oxidase is required for the assembly/stability of respiratory complex I in mouse fibroblasts., Molecular and cellular biology, 2006, 26
  http://rdf.ncbi.nlm.nih.gov/pubmed/16782876
• Hirokazu. Fukui, et.al., Cytochrome c oxidase deficiency in neurons decreases both oxidative stress and amyloid formation in a mouse model of Alzheimer's disease., Proceedings of the National Academy of Sciences of the United States of America, 2007, 104
  http://rdf.ncbi.nlm.nih.gov/pubmed/17715058
• Tina. Wenz, et.al., Endurance exercise is protective for mice with mitochondrial myopathy., Journal of applied physiology (Bethesda, Md. : 1985), 2009, 106
  http://rdf.ncbi.nlm.nih.gov/pubmed/19286571
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• mitochondrial membrane
  http://purl.obolibrary.org/obo/GO_0031966
• heme O biosynthetic process
  http://purl.obolibrary.org/obo/GO_0048034
• prenyltransferase activity
  http://purl.obolibrary.org/obo/GO_0004659
• transferase activity
  http://purl.obolibrary.org/obo/GO_0016740
• cellular respiration
  http://purl.obolibrary.org/obo/GO_0045333
• respiratory chain complex IV assembly
  http://purl.obolibrary.org/obo/GO_0008535
• cytochrome complex assembly
  http://purl.obolibrary.org/obo/GO_0017004
• aerobic respiration
  http://purl.obolibrary.org/obo/GO_0009060
• mitochondrion
  http://purl.obolibrary.org/obo/GO_0005739
• membrane
  http://purl.obolibrary.org/obo/GO_0016020
• mitochondrion organization
  http://purl.obolibrary.org/obo/GO_0007005
• protein farnesylation
  http://purl.obolibrary.org/obo/GO_0018343
• protoheme IX farnesyltransferase activity
  http://purl.obolibrary.org/obo/GO_0008495
• integral component of membrane
  http://purl.obolibrary.org/obo/GO_0016021
• farnesyltranstransferase activity
  http://purl.obolibrary.org/obo/GO_0004311
• heme biosynthetic process
  http://purl.obolibrary.org/obo/GO_0006783
• mitochondrial fission
  http://purl.obolibrary.org/obo/GO_0000266
• heme a biosynthetic process
  http://purl.obolibrary.org/obo/GO_0006784

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map01100
• http://www.genome.jp/dbget-bin/www_bget?map00190
• http://www.genome.jp/dbget-bin/www_bget?map00860

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Metabolic pathways
• Porphyrin and chlorophyll metabolism
• Oxidative phosphorylation