CD39429

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD39429

CD39429

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Krit1

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• KRIT1, ankyrin repeat containing

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• cerebral cavernous malformations 1 protein homolog
• krev interaction trapped 1
• krev interaction trapped protein 1
• KRIT1, ankyrin repeat containing

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• Krit1B
• AI450393
• AI643869
• Ccm1
• Krit1
• Krit1A
• 2010007K12Rik
• BB235701
• AA432855
• BB155247
• A630036P20Rik

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/79264

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• KRIT1, ankyrin repeat containing
  http://metadb.riken.jp/db/mgi_rdf/MGI:1930618

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_001170552
• https://www.ncbi.nlm.nih.gov/nuccore/NM_030675

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000000600

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.482273
• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.32368

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=604214

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• C. Denier, et.al., Krit1/cerebral cavernous malformation 1 mRNA is preferentially expressed in neurons and epithelial cells in embryo and adult., Mechanisms of development, 2002, 117
  http://rdf.ncbi.nlm.nih.gov/pubmed/12204286
• David A. McDonald, et.al., A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease., Human molecular genetics, 2011, 20
  http://rdf.ncbi.nlm.nih.gov/pubmed/20940147
• Rebecca A. Stockton, et.al., Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity., The Journal of experimental medicine, 2010, 207
  http://rdf.ncbi.nlm.nih.gov/pubmed/20308363
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• T. Sahoo, et.al., Computational and experimental analyses reveal previously undetected coding exons of the KRIT1 (CCM1) gene., Genomics, 2001, 71
  http://rdf.ncbi.nlm.nih.gov/pubmed/11161805
• J. Zhang, et.al., Cloning of the murine Krit1 cDNA reveals novel mammalian 5' coding exons., Genomics, 2000, 70
  http://rdf.ncbi.nlm.nih.gov/pubmed/11161791
• Luca. Goitre, et.al., KRIT1 regulates the homeostasis of intracellular reactive oxygen species., PloS one, 2010, 5
  http://rdf.ncbi.nlm.nih.gov/pubmed/20668652
• I. Eerola, et.al., Identification of eight novel 5'-exons in cerebral capillary malformation gene-1 (CCM1) encoding KRIT1., Biochimica et biophysica acta, 2001, 1517
  http://rdf.ncbi.nlm.nih.gov/pubmed/11342228
• Hildegard. Kehrer-Sawatzki, et.al., Mutation and expression analysis of the KRIT1 gene associated with cerebral cavernous malformations (CCM1)., Acta neuropathologica, 2002, 104
  http://rdf.ncbi.nlm.nih.gov/pubmed/12172908
• http://rdf.ncbi.nlm.nih.gov/pubmed/20007487

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• negative regulation of endothelial cell apoptotic process
  http://purl.obolibrary.org/obo/GO_2000352
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• regulation of establishment of cell polarity
  http://purl.obolibrary.org/obo/GO_2000114
• binding
  http://purl.obolibrary.org/obo/GO_0005488
• cytoskeleton
  http://purl.obolibrary.org/obo/GO_0005856
• cell redox homeostasis
  http://purl.obolibrary.org/obo/GO_0045454
• membrane
  http://purl.obolibrary.org/obo/GO_0016020
• angiogenesis
  http://purl.obolibrary.org/obo/GO_0001525
• negative regulation of angiogenesis
  http://purl.obolibrary.org/obo/GO_0016525
• cell-cell junction
  http://purl.obolibrary.org/obo/GO_0005911
• positive regulation of protein binding
  http://purl.obolibrary.org/obo/GO_0032092
• GTPase regulator activity
  http://purl.obolibrary.org/obo/GO_0030695
• macromolecular complex
  http://purl.obolibrary.org/obo/GO_0032991
• negative regulation of endothelial cell proliferation
  http://purl.obolibrary.org/obo/GO_0001937
• cell junction
  http://purl.obolibrary.org/obo/GO_0030054
• negative regulation of endothelial cell migration
  http://purl.obolibrary.org/obo/GO_0010596

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName