CD39903

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD39903

CD39903

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Mbd4

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• methyl-CpG binding domain protein 4

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• mismatch-specific DNA N-glycosylase
• methyl-CpG-binding domain protein 4
• methyl-CpG-binding protein MBD4
• methyl-CpG binding domain protein 4

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• Med1

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/17193

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• methyl-CpG binding domain protein 4
  http://metadb.riken.jp/db/mgi_rdf/MGI:1333850

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_010774

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000030322

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.259308

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=603574

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• I. Ohki, et.al., Solution structure of the methyl-CpG binding domain of human MBD1 in complex with methylated DNA., Cell, 2001, 105
  http://rdf.ncbi.nlm.nih.gov/pubmed/11371345
• B. Hendrich, et.al., The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites., Nature, 1999, 401
  http://rdf.ncbi.nlm.nih.gov/pubmed/10499592
• Wolfgang. Mann, et.al., Single cell RT-PCR on mouse embryos: a general approach for developmental biology., Methods in molecular biology (Clifton, N.J.), 2010, 630
  http://rdf.ncbi.nlm.nih.gov/pubmed/20300987
• Petra. Hajkova, et.al., Genome-wide reprogramming in the mouse germ line entails the base excision repair pathway., Science (New York, N.Y.), 2010, 329
  http://rdf.ncbi.nlm.nih.gov/pubmed/20595612
• B. Hendrich, et.al., Identification and characterization of a family of mammalian methyl-CpG binding proteins., Molecular and cellular biology, 1998, 18
  http://rdf.ncbi.nlm.nih.gov/pubmed/9774669
• Alexey. Ruzov, et.al., MBD4 and MLH1 are required for apoptotic induction in xDNMT1-depleted embryos., Development (Cambridge, England), 2009, 136
  http://rdf.ncbi.nlm.nih.gov/pubmed/19502488
• Salvatore. Cortellino, et.al., Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4., Developmental biology, 2009, 325
  http://rdf.ncbi.nlm.nih.gov/pubmed/19000668
• F. Laub, et.al., Developmental expression of mouse Krüppel-like transcription factor KLF7 suggests a potential role in neurogenesis., Developmental biology, 2001, 233
  http://rdf.ncbi.nlm.nih.gov/pubmed/11336497
• B. Hendrich, et.al., Genomic structure and chromosomal mapping of the murine and human Mbd1, Mbd2, Mbd3, and Mbd4 genes., Mammalian genome : official journal of the International Mammalian Genome Society, 1999, 10
  http://rdf.ncbi.nlm.nih.gov/pubmed/10441743
• Mi-Sun. Kim, et.al., DNA demethylation in hormone-induced transcriptional derepression., Nature, 2009, 461
  http://rdf.ncbi.nlm.nih.gov/pubmed/19829383

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• nucleus
  http://purl.obolibrary.org/obo/GO_0005634
• DNA repair
  http://purl.obolibrary.org/obo/GO_0006281
• intrinsic apoptotic signaling pathway in response to DNA damage
  http://purl.obolibrary.org/obo/GO_0008630
• response to radiation
  http://purl.obolibrary.org/obo/GO_0009314
• base-excision repair
  http://purl.obolibrary.org/obo/GO_0006284
• DNA binding
  http://purl.obolibrary.org/obo/GO_0003677
• catalytic activity
  http://purl.obolibrary.org/obo/GO_0003824
• intracellular
  http://purl.obolibrary.org/obo/GO_0005622
• DNA methylation
  http://purl.obolibrary.org/obo/GO_0006306
• hydrolase activity
  http://purl.obolibrary.org/obo/GO_0016787
• cellular response to DNA damage stimulus
  http://purl.obolibrary.org/obo/GO_0006974
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• chromatin
  http://purl.obolibrary.org/obo/GO_0000785

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map03410

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Base excision repair