CD40264

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD40264

CD40264

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Ilk

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• integrin linked kinase

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• integrin binding protein kinase
• integrin linked kinase
• integrin-linked protein kinase

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• ESTM24
• AA511515

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/16202

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• integrin linked kinase
  http://metadb.riken.jp/db/mgi_rdf/MGI:1195267

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_001161724
• https://www.ncbi.nlm.nih.gov/nuccore/NM_010562

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000030890

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.285771
• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.274846

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=602366

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Vinicio A de Jesus. Perez, et.al., BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways., The Journal of cell biology, 2011, 192
  http://rdf.ncbi.nlm.nih.gov/pubmed/21220513
• D E. White, et.al., Mammary epithelial-specific expression of the integrin-linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice., Oncogene, 2001, 20
  http://rdf.ncbi.nlm.nih.gov/pubmed/11704830
• Panagiotis. Kavvadas, et.al., Integrin-linked kinase (ILK) in pulmonary fibrosis., Virchows Archiv : an international journal of pathology, 2010, 457
  http://rdf.ncbi.nlm.nih.gov/pubmed/20857141
• Yongjun. Zhang, et.al., Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites., Journal of cell science, 2002, 115
  http://rdf.ncbi.nlm.nih.gov/pubmed/12432066
• Sara A. Wickström, et.al., Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolae., Developmental cell, 2010, 19
  http://rdf.ncbi.nlm.nih.gov/pubmed/20951348
• F. Li, et.al., Identification and characterization of a mouse protein kinase that is highly homologous to human integrin-linked kinase., Biochimica et biophysica acta, 1997, 1358
  http://rdf.ncbi.nlm.nih.gov/pubmed/9366252
• S N. Nikolopoulos, et.al., Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization to focal adhesions., The Journal of biological chemistry, 2001, 276
  http://rdf.ncbi.nlm.nih.gov/pubmed/11304546
• Chiara. Verpelli, et.al., Anti-angiogenic therapy induces integrin-linked kinase 1 up-regulation in a mouse model of glioblastoma., PloS one, 2010, 5
  http://rdf.ncbi.nlm.nih.gov/pubmed/21060779
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• Alisa. Vespa, et.al., Ca2+-dependent localization of integrin-linked kinase to cell junctions in differentiating keratinocytes., The Journal of biological chemistry, 2003, 278
  http://rdf.ncbi.nlm.nih.gov/pubmed/12547824

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• fibril organization
  http://purl.obolibrary.org/obo/GO_0097435
• negative regulation of apoptotic process
  http://purl.obolibrary.org/obo/GO_0043066
• cell aging
  http://purl.obolibrary.org/obo/GO_0007569
• negative regulation of protein kinase activity
  http://purl.obolibrary.org/obo/GO_0006469
• neuronal cell body
  http://purl.obolibrary.org/obo/GO_0043025
• signal transduction
  http://purl.obolibrary.org/obo/GO_0007165
• ATP binding
  http://purl.obolibrary.org/obo/GO_0005524
• terminal bouton
  http://purl.obolibrary.org/obo/GO_0043195
• cell junction
  http://purl.obolibrary.org/obo/GO_0030054
• protein heterooligomerization
  http://purl.obolibrary.org/obo/GO_0051291
• positive regulation of axon extension
  http://purl.obolibrary.org/obo/GO_0045773
• regulation of cell growth
  http://purl.obolibrary.org/obo/GO_0001558
• kinase activity
  http://purl.obolibrary.org/obo/GO_0016301
• protein serine/threonine kinase activity
  http://purl.obolibrary.org/obo/GO_0004674
• positive regulation of transcription, DNA-templated
  http://purl.obolibrary.org/obo/GO_0045893
• positive regulation of MAP kinase activity
  http://purl.obolibrary.org/obo/GO_0043406
• axon
  http://purl.obolibrary.org/obo/GO_0030424
• myelin assembly
  http://purl.obolibrary.org/obo/GO_0032288
• negative regulation of neuron apoptotic process
  http://purl.obolibrary.org/obo/GO_0043524
• neuron projection morphogenesis
  http://purl.obolibrary.org/obo/GO_0048812
• integrin-mediated signaling pathway
  http://purl.obolibrary.org/obo/GO_0007229
• positive regulation of MAPK cascade
  http://purl.obolibrary.org/obo/GO_0043410
• membrane
  http://purl.obolibrary.org/obo/GO_0016020
• focal adhesion
  http://purl.obolibrary.org/obo/GO_0005925
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• protein kinase binding
  http://purl.obolibrary.org/obo/GO_0019901
• signal transducer activity
  http://purl.obolibrary.org/obo/GO_0004871
• establishment or maintenance of epithelial cell apical/basal polarity
  http://purl.obolibrary.org/obo/GO_0045197
• positive regulation of cell migration
  http://purl.obolibrary.org/obo/GO_0030335
• transferase activity
  http://purl.obolibrary.org/obo/GO_0016740
• positive regulation of myoblast differentiation
  http://purl.obolibrary.org/obo/GO_0045663
• positive regulation of BMP signaling pathway
  http://purl.obolibrary.org/obo/GO_0030513
• phosphorylation
  http://purl.obolibrary.org/obo/GO_0016310
• SH3 domain binding
  http://purl.obolibrary.org/obo/GO_0017124
• macromolecular complex
  http://purl.obolibrary.org/obo/GO_0032991
• stress fiber
  http://purl.obolibrary.org/obo/GO_0001725
• positive regulation of phosphorylation
  http://purl.obolibrary.org/obo/GO_0042327
• costamere
  http://purl.obolibrary.org/obo/GO_0043034
• positive regulation of cell proliferation
  http://purl.obolibrary.org/obo/GO_0008284
• cell cycle arrest
  http://purl.obolibrary.org/obo/GO_0007050
• regulation of actin cytoskeleton organization
  http://purl.obolibrary.org/obo/GO_0032956
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• integrin binding
  http://purl.obolibrary.org/obo/GO_0005178
• nucleotide binding
  http://purl.obolibrary.org/obo/GO_0000166
• regulation of signal transduction
  http://purl.obolibrary.org/obo/GO_0009966
• protein phosphorylation
  http://purl.obolibrary.org/obo/GO_0006468
• positive regulation of dendrite morphogenesis
  http://purl.obolibrary.org/obo/GO_0050775
• substrate adhesion-dependent cell spreading
  http://purl.obolibrary.org/obo/GO_0034446
• negative regulation of cardiac muscle cell apoptotic process
  http://purl.obolibrary.org/obo/GO_0010667
• negative regulation of smooth muscle cell migration
  http://purl.obolibrary.org/obo/GO_0014912
• dendritic shaft
  http://purl.obolibrary.org/obo/GO_0043198
• peptidyl-serine phosphorylation
  http://purl.obolibrary.org/obo/GO_0018105
• transferase activity, transferring phosphorus-containing groups
  http://purl.obolibrary.org/obo/GO_0016772
• negative regulation of smooth muscle cell proliferation
  http://purl.obolibrary.org/obo/GO_0048662
• branching involved in ureteric bud morphogenesis
  http://purl.obolibrary.org/obo/GO_0001658
• positive regulation of protein kinase B signaling
  http://purl.obolibrary.org/obo/GO_0051897
• positive regulation of osteoblast differentiation
  http://purl.obolibrary.org/obo/GO_0045669
• positive regulation of canonical Wnt signaling pathway
  http://purl.obolibrary.org/obo/GO_0090263
• positive regulation of axonogenesis
  http://purl.obolibrary.org/obo/GO_0050772
• positive regulation of cell-matrix adhesion
  http://purl.obolibrary.org/obo/GO_0001954
• cell-cell junction
  http://purl.obolibrary.org/obo/GO_0005911
• plasma membrane
  http://purl.obolibrary.org/obo/GO_0005886
• protein kinase activity
  http://purl.obolibrary.org/obo/GO_0004672

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map03320
• http://www.genome.jp/dbget-bin/www_bget?map04510
• http://www.genome.jp/dbget-bin/www_bget?map05213
• http://www.genome.jp/dbget-bin/www_bget?map05100

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Endometrial cancer
• Focal adhesion
• PPAR signaling pathway
• Bacterial invasion of epithelial cells