CD40300

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD40300

CD40300

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Il2

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• interleukin 2

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• T-cell growth factor
• interleukin 2
• TCGF
• interleukin-2

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• Il-2
• IL-2

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/16183

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• interleukin 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:96548

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_008366

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000027720

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.14190

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=147680

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• C M L. de Melo, et.al., Mitogenic response and cytokine production induced by cramoll 1,4 lectin in splenocytes of inoculated mice., Scandinavian journal of immunology, 2011, 73
  http://rdf.ncbi.nlm.nih.gov/pubmed/21198751
• Rahul. Sharma, et.al., IL-2-controlled expression of multiple T cell trafficking genes and Th2 cytokines in the regulatory T cell-deficient scurfy mice: implication to multiorgan inflammation and control of skin and lung inflammation., Journal of immunology (Baltimore, Md. : 1950), 2011, 186
  http://rdf.ncbi.nlm.nih.gov/pubmed/21169543
• Melanie. Wiesel, et.al., Type I IFN substitutes for T cell help during viral infections., Journal of immunology (Baltimore, Md. : 1950), 2011, 186
  http://rdf.ncbi.nlm.nih.gov/pubmed/21160039
• T. Yamashita, et.al., IL-4 influences IL-2 production and granulomatous inflammation in murine schistosomiasis mansoni., Journal of immunology (Baltimore, Md. : 1950), 1992, 149
  http://rdf.ncbi.nlm.nih.gov/pubmed/1431136
• Xiang-Ping. Yang, et.al., Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5., Nature immunology, 2011, 12
  http://rdf.ncbi.nlm.nih.gov/pubmed/21278738
• Daisuke. Kimura, et.al., Production of IFN-γ by CD4(+) T cells in response to malaria antigens is IL-2 dependent., International immunology, 2010, 22
  http://rdf.ncbi.nlm.nih.gov/pubmed/21059770
• F. Matesanz, et.al., A new cDNA sequence for the murine interleukin-2 gene., Biochimica et biophysica acta, 1992, 1132
  http://rdf.ncbi.nlm.nih.gov/pubmed/1420317
• F. Cavallo, et.al., Role of neutrophils and CD4+ T lymphocytes in the primary and memory response to nonimmunogenic murine mammary adenocarcinoma made immunogenic by IL-2 gene., Journal of immunology (Baltimore, Md. : 1950), 1992, 149
  http://rdf.ncbi.nlm.nih.gov/pubmed/1358974
• F. Wang, et.al., Calcitonin gene-related peptide inhibits interleukin 2 production by murine T lymphocytes., The Journal of biological chemistry, 1992, 267
  http://rdf.ncbi.nlm.nih.gov/pubmed/1383217
• T S. Kim, et.al., Immunity to B16 melanoma in mice immunized with IL-2-secreting allogeneic mouse fibroblasts expressing melanoma-associated antigens., International journal of cancer, 1992, 51
  http://rdf.ncbi.nlm.nih.gov/pubmed/1533203

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• cytosol
  http://purl.obolibrary.org/obo/GO_0005829
• positive regulation of T cell proliferation
  http://purl.obolibrary.org/obo/GO_0042102
• positive regulation of interferon-gamma production
  http://purl.obolibrary.org/obo/GO_0032729
• positive regulation of B cell proliferation
  http://purl.obolibrary.org/obo/GO_0030890
• regulation of T cell homeostatic proliferation
  http://purl.obolibrary.org/obo/GO_0046013
• extracellular region
  http://purl.obolibrary.org/obo/GO_0005576
• protein kinase C-activating G-protein coupled receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0007205
• positive regulation of interleukin-17 production
  http://purl.obolibrary.org/obo/GO_0032740
• positive regulation of immunoglobulin secretion
  http://purl.obolibrary.org/obo/GO_0051024
• negative regulation of heart contraction
  http://purl.obolibrary.org/obo/GO_0045822
• positive regulation of T cell differentiation
  http://purl.obolibrary.org/obo/GO_0045582
• cytokine activity
  http://purl.obolibrary.org/obo/GO_0005125
• G-protein coupled receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0007186
• positive regulation of regulatory T cell differentiation
  http://purl.obolibrary.org/obo/GO_0045591
• extracellular space
  http://purl.obolibrary.org/obo/GO_0005615
• immune response
  http://purl.obolibrary.org/obo/GO_0006955
• positive regulation of protein phosphorylation
  http://purl.obolibrary.org/obo/GO_0001934
• negative regulation of lymphocyte proliferation
  http://purl.obolibrary.org/obo/GO_0050672
• interleukin-2 receptor binding
  http://purl.obolibrary.org/obo/GO_0005134
• negative regulation of B cell apoptotic process
  http://purl.obolibrary.org/obo/GO_0002903
• positive regulation of isotype switching to IgG isotypes
  http://purl.obolibrary.org/obo/GO_0048304
• growth factor activity
  http://purl.obolibrary.org/obo/GO_0008083
• positive regulation of transcription from RNA polymerase II promoter
  http://purl.obolibrary.org/obo/GO_0045944
• positive regulation of cytosolic calcium ion concentration
  http://purl.obolibrary.org/obo/GO_0007204
• kappa-type opioid receptor binding
  http://purl.obolibrary.org/obo/GO_0031851
• negative regulation of inflammatory response
  http://purl.obolibrary.org/obo/GO_0050728
• carbohydrate binding
  http://purl.obolibrary.org/obo/GO_0030246
• negative regulation of protein phosphorylation
  http://purl.obolibrary.org/obo/GO_0001933
• positive regulation of tyrosine phosphorylation of STAT protein
  http://purl.obolibrary.org/obo/GO_0042531
• positive regulation of dendritic spine development
  http://purl.obolibrary.org/obo/GO_0060999
• glycosphingolipid binding
  http://purl.obolibrary.org/obo/GO_0043208
• positive regulation of activated T cell proliferation
  http://purl.obolibrary.org/obo/GO_0042104

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map05330
• http://www.genome.jp/dbget-bin/www_bget?map04660
• http://www.genome.jp/dbget-bin/www_bget?map05320
• http://www.genome.jp/dbget-bin/www_bget?map04060
• http://www.genome.jp/dbget-bin/www_bget?map04630
• http://www.genome.jp/dbget-bin/www_bget?map05162
• http://www.genome.jp/dbget-bin/www_bget?map04940
• http://www.genome.jp/dbget-bin/www_bget?map04672
• http://www.genome.jp/dbget-bin/www_bget?map05142
• http://www.genome.jp/dbget-bin/www_bget?map05166
• http://www.genome.jp/dbget-bin/www_bget?map05332

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• HTLV-I infection
• Allograft rejection
• Measles
• Jak-STAT signaling pathway
• Type I diabetes mellitus
• Chagas disease (American trypanosomiasis)
• Graft-versus-host disease
• Autoimmune thyroid disease
• Cytokine-cytokine receptor interaction
• T cell receptor signaling pathway
• Intestinal immune network for IgA production