CD40485

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD40485

CD40485

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Clcf1

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• cardiotrophin-like cytokine factor 1

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• cardiotrophin-like cytokine factor 1
• BSF-3
• b cell-stimulating factor 3
• B-cell-stimulating factor 3
• novel neurotrophin-1
• NNT-1
• B-cell stimulating factor 3
• neurotrophin-1/B-cell stimulating factor-3

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• CLC
• Bsf3
• NNT-1/BSF-3

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/56708

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• cardiotrophin-like cytokine factor 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1930088

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_019952

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000040663

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.347919

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=607672

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Nancy G. Forger, et.al., Cardiotrophin-like cytokine/cytokine-like factor 1 is an essential trophic factor for lumbar and facial motoneurons in vivo., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, 23
  http://rdf.ncbi.nlm.nih.gov/pubmed/14523086
• George. Vlotides, et.al., Expression of novel neurotrophin-1/B-cell stimulating factor-3 (NNT-1/BSF-3) in murine pituitary folliculostellate TtT/GF cells: pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal peptide-induced stimulation of NNT-1/BSF-3 is mediated by protein kinase A, protein kinase C, and extracellular-signal-regulated kinase1/2 pathways., Endocrinology, 2004, 145
  http://rdf.ncbi.nlm.nih.gov/pubmed/14605001
• http://rdf.ncbi.nlm.nih.gov/pubmed/15683542
• G. Senaldi, et.al., Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family., Proceedings of the National Academy of Sciences of the United States of America, 1999, 96
  http://rdf.ncbi.nlm.nih.gov/pubmed/10500198
• Atsumi. Uemura, et.al., Cardiotrophin-like cytokine induces astrocyte differentiation of fetal neuroepithelial cells via activation of STAT3., Cytokine, 2002, 18
  http://rdf.ncbi.nlm.nih.gov/pubmed/12090754
• Masaaki. Murakami, et.al., New IL-6 (gp130) family cytokine members, CLC/NNT1/BSF3 and IL-27., Growth factors (Chur, Switzerland), 2004, 22
  http://rdf.ncbi.nlm.nih.gov/pubmed/15253382
• Stephan. Oberle, et.al., Loss of leukemia inhibitory factor receptor beta or cardiotrophin-1 causes similar deficits in preganglionic sympathetic neurons and adrenal medulla., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, 26
  http://rdf.ncbi.nlm.nih.gov/pubmed/16467531
• X. Zou, et.al., Neonatal death in mice lacking cardiotrophin-like cytokine is associated with multifocal neuronal hypoplasia., Veterinary pathology, 2009, 46
  http://rdf.ncbi.nlm.nih.gov/pubmed/19098279
• Damien. Derouet, et.al., Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor., Proceedings of the National Academy of Sciences of the United States of America, 2004, 101
  http://rdf.ncbi.nlm.nih.gov/pubmed/15051883

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• negative regulation of neuron apoptotic process
  http://purl.obolibrary.org/obo/GO_0043524
• positive regulation of isotype switching to IgE isotypes
  http://purl.obolibrary.org/obo/GO_0048295
• regulation of ERK1 and ERK2 cascade
  http://purl.obolibrary.org/obo/GO_0070372
• extracellular space
  http://purl.obolibrary.org/obo/GO_0005615
• positive regulation of astrocyte differentiation
  http://purl.obolibrary.org/obo/GO_0048711
• positive regulation of immunoglobulin production
  http://purl.obolibrary.org/obo/GO_0002639
• protein heterodimerization activity
  http://purl.obolibrary.org/obo/GO_0046982
• receptor binding
  http://purl.obolibrary.org/obo/GO_0005102
• ciliary neurotrophic factor receptor binding
  http://purl.obolibrary.org/obo/GO_0005127
• B cell differentiation
  http://purl.obolibrary.org/obo/GO_0030183
• JAK-STAT cascade
  http://purl.obolibrary.org/obo/GO_0007259
• cytokine activity
  http://purl.obolibrary.org/obo/GO_0005125
• positive regulation of tyrosine phosphorylation of STAT protein
  http://purl.obolibrary.org/obo/GO_0042531
• intracellular
  http://purl.obolibrary.org/obo/GO_0005622
• regulation of protein kinase B signaling
  http://purl.obolibrary.org/obo/GO_0051896
• regulation of inflammatory response
  http://purl.obolibrary.org/obo/GO_0050727
• positive regulation of corticotropin-releasing hormone secretion
  http://purl.obolibrary.org/obo/GO_0051466
• positive regulation of B cell proliferation
  http://purl.obolibrary.org/obo/GO_0030890
• positive regulation of cell proliferation
  http://purl.obolibrary.org/obo/GO_0008284
• extracellular region
  http://purl.obolibrary.org/obo/GO_0005576
• positive regulation of type 2 immune response
  http://purl.obolibrary.org/obo/GO_0002830
• cell surface receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0007166

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04630
• http://www.genome.jp/dbget-bin/www_bget?map04060

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Jak-STAT signaling pathway
• Cytokine-cytokine receptor interaction