CD41105

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD41105

CD41105

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Traf2

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• TNF receptor-associated factor 2

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• TNF receptor-associated factor 2
• E3 ubiquitin-protein ligase TRAF2

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• AI325259

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/22030

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• TNF receptor-associated factor 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:101835

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_009422

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000026942

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.3399

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=601895

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• M. Rothe, et.al., A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor., Cell, 1994, 78
  http://rdf.ncbi.nlm.nih.gov/pubmed/8069916
• Daniel. Yacoub, et.al., Enhanced levels of soluble CD40 ligand exacerbate platelet aggregation and thrombus formation through a CD40-dependent tumor necrosis factor receptor-associated factor-2/Rac1/p38 mitogen-activated protein kinase signaling pathway., Arteriosclerosis, thrombosis, and vascular biology, 2010, 30
  http://rdf.ncbi.nlm.nih.gov/pubmed/21071692
• S Y. Lee, et.al., T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor necrosis factor receptor-associated factors., The Journal of experimental medicine, 1996, 183
  http://rdf.ncbi.nlm.nih.gov/pubmed/8627180
• Lucy A. Perrone, et.al., Mice lacking both TNF and IL-1 receptors exhibit reduced lung inflammation and delay in onset of death following infection with a highly virulent H5N1 virus., The Journal of infectious diseases, 2010, 202
  http://rdf.ncbi.nlm.nih.gov/pubmed/20815704
• Bruce S. Hostager, et.al., HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex., PloS one, 2010, 5
  http://rdf.ncbi.nlm.nih.gov/pubmed/20614026
• S Y. Lee, et.al., TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation., The Journal of experimental medicine, 1997, 185
  http://rdf.ncbi.nlm.nih.gov/pubmed/9104814
• H Y. Song, et.al., The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation., Proceedings of the National Academy of Sciences of the United States of America, 1996, 93
  http://rdf.ncbi.nlm.nih.gov/pubmed/8692885
• H. Hsu, et.al., TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways., Cell, 1996, 84
  http://rdf.ncbi.nlm.nih.gov/pubmed/8565075
• Jian. Liang, et.al., MCP-induced protein 1 deubiquitinates TRAF proteins and negatively regulates JNK and NF-kappaB signaling., The Journal of experimental medicine, 2010, 207
  http://rdf.ncbi.nlm.nih.gov/pubmed/21115689
• Miki. Shitashige, et.al., Traf2- and Nck-interacting kinase is essential for Wnt signaling and colorectal cancer growth., Cancer research, 2010, 70
  http://rdf.ncbi.nlm.nih.gov/pubmed/20530691

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• macromolecular complex assembly
  http://purl.obolibrary.org/obo/GO_0065003
• protein autoubiquitination
  http://purl.obolibrary.org/obo/GO_0051865
• lipid binding
  http://purl.obolibrary.org/obo/GO_0006630
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• protein K63-linked ubiquitination
  http://purl.obolibrary.org/obo/GO_0070534
• membrane raft
  http://purl.obolibrary.org/obo/GO_0045121
• positive regulation of T cell cytokine production
  http://purl.obolibrary.org/obo/GO_0002726
• signaling receptor activity
  http://purl.obolibrary.org/obo/GO_0038023
• metabolic process
  http://purl.obolibrary.org/obo/GO_0008152
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• zinc ion binding
  http://purl.obolibrary.org/obo/GO_0008270
• cellular macromolecular complex assembly
  http://purl.obolibrary.org/obo/GO_0034622
• cytoplasmic side of plasma membrane
  http://purl.obolibrary.org/obo/GO_0009898
• positive regulation of NF-kappaB transcription factor activity
  http://purl.obolibrary.org/obo/GO_0051092
• ligase activity
  http://purl.obolibrary.org/obo/GO_0016874
• positive regulation of JUN kinase activity
  http://purl.obolibrary.org/obo/GO_0043507
• negative regulation of apoptotic process
  http://purl.obolibrary.org/obo/GO_0043066
• cell cortex
  http://purl.obolibrary.org/obo/GO_0005938
• mitogen-activated protein kinase kinase kinase binding
  http://purl.obolibrary.org/obo/GO_0031435
• cargo receptor activity
  http://purl.obolibrary.org/obo/GO_0038024
• regulation of apoptotic process
  http://purl.obolibrary.org/obo/GO_0042981
• signal transduction
  http://purl.obolibrary.org/obo/GO_0007165
• macromolecular complex
  http://purl.obolibrary.org/obo/GO_0032991
• metal ion binding
  http://purl.obolibrary.org/obo/GO_0046872
• CD40 receptor binding
  http://purl.obolibrary.org/obo/GO_0005174
• protein homotrimerization
  http://purl.obolibrary.org/obo/GO_0070207
• identical protein binding
  http://purl.obolibrary.org/obo/GO_0042802
• activation of NF-kappaB-inducing kinase activity
  http://purl.obolibrary.org/obo/GO_0007250
• protein catabolic process
  http://purl.obolibrary.org/obo/GO_0030163
• receptor binding
  http://purl.obolibrary.org/obo/GO_0005102
• negative regulation of glial cell apoptotic process
  http://purl.obolibrary.org/obo/GO_0034351
• regulation of immunoglobulin secretion
  http://purl.obolibrary.org/obo/GO_0051023
• lipid binding
  http://purl.obolibrary.org/obo/GO_0008289
• protein heterooligomerization
  http://purl.obolibrary.org/obo/GO_0051291
• sphingolipid binding
  http://purl.obolibrary.org/obo/GO_0046625
• apoptotic process
  http://purl.obolibrary.org/obo/GO_0006915
• CD40 receptor complex
  http://purl.obolibrary.org/obo/GO_0035631
• macromolecular complex binding
  http://purl.obolibrary.org/obo/GO_0044877
• tumor necrosis factor-mediated signaling pathway
  http://purl.obolibrary.org/obo/GO_0033209
• enzyme binding
  http://purl.obolibrary.org/obo/GO_0019899
• regulation of JNK cascade
  http://purl.obolibrary.org/obo/GO_0046328
• positive regulation of sequence-specific DNA binding transcription factor activity
  http://purl.obolibrary.org/obo/GO_0051091
• positive regulation of interleukin-2 production
  http://purl.obolibrary.org/obo/GO_0032743

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04141
• http://www.genome.jp/dbget-bin/www_bget?map05160
• http://www.genome.jp/dbget-bin/www_bget?map04010
• http://www.genome.jp/dbget-bin/www_bget?map05168
• http://www.genome.jp/dbget-bin/www_bget?map04210
• http://www.genome.jp/dbget-bin/www_bget?map04920
• http://www.genome.jp/dbget-bin/www_bget?map05222
• http://www.genome.jp/dbget-bin/www_bget?map04622
• http://www.genome.jp/dbget-bin/www_bget?map04380
• http://www.genome.jp/dbget-bin/www_bget?map05200

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Apoptosis
• Small cell lung cancer
• Herpes simplex infection
• Protein processing in endoplasmic reticulum
• Adipocytokine signaling pathway
• MAPK signaling pathway
• Hepatitis C
• Osteoclast differentiation
• RIG-I-like receptor signaling pathway
• Pathways in cancer