CD43637

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD43637

CD43637

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Pah

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• phenylalanine hydroxylase

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• phenylalanine-4-hydroxylase
• phe-4-monooxygenase
• phenylalanine hydroxylase

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• AW106920

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/18478

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• phenylalanine hydroxylase
  http://metadb.riken.jp/db/mgi_rdf/MGI:97473

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_008777

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000020051

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.263539

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=612349

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• Florian B. Lagler, et.al., New insights into tetrahydrobiopterin pharmacodynamics from Pah enu1/2, a mouse model for compound heterozygous tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency., Biochemical pharmacology, 2010, 80
  http://rdf.ncbi.nlm.nih.gov/pubmed/20705059
• Søren W. Gersting, et.al., Pahenu1 is a mouse model for tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency and promotes analysis of the pharmacological chaperone mechanism in vivo., Human molecular genetics, 2010, 19
  http://rdf.ncbi.nlm.nih.gov/pubmed/20179079
• Renaud. Schoemans, et.al., Oligodendrocyte development and myelinogenesis are not impaired by high concentrations of phenylalanine or its metabolites., Journal of inherited metabolic disease, 2010, 33
  http://rdf.ncbi.nlm.nih.gov/pubmed/20151197
• Richard S. Gunasekera, et.al., In vivo regulation of phenylalanine hydroxylase in the genetic mutant hph-1 mouse model., Molecular genetics and metabolism, 2009, 98
  http://rdf.ncbi.nlm.nih.gov/pubmed/19560382
• T J. Liu, et.al., Reconstitution of enzymatic activity in hepatocytes of phenylalanine hydroxylase-deficient mice., Somatic cell and molecular genetics, 1992, 18
  http://rdf.ncbi.nlm.nih.gov/pubmed/1312261
• D. Simon-Chazottes, et.al., Chromosomal localization of two cell surface-associated molecules of potential importance in development: midkine (Mdk) and basigin (Bsg)., Mammalian genome : official journal of the International Mammalian Genome Society, 1992, 2
  http://rdf.ncbi.nlm.nih.gov/pubmed/1347477
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• D C. MacLaren, et.al., The L-isoaspartyl/D-aspartyl protein methyltransferase gene (PCMT1) maps to human chromosome 6q22.3-6q24 and the syntenic region of mouse chromosome 10., Genomics, 1992, 14
  http://rdf.ncbi.nlm.nih.gov/pubmed/1478665
• T M. Wilkie, et.al., Evolution of the mammalian G protein alpha subunit multigene family., Nature genetics, 1992, 1
  http://rdf.ncbi.nlm.nih.gov/pubmed/1302014
• A. Shimizu, et.al., A molecular genetic linkage map of mouse chromosome 10, including the Myb, S100b, Pah, Sl, and Ifg genes., Biochemical genetics, 1992, 30
  http://rdf.ncbi.nlm.nih.gov/pubmed/1359872

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• catalytic activity
  http://purl.obolibrary.org/obo/GO_0003824
• aromatic amino acid family metabolic process
  http://purl.obolibrary.org/obo/GO_0009072
• L-phenylalanine metabolic process
  http://purl.obolibrary.org/obo/GO_0006558
• iron ion binding
  http://purl.obolibrary.org/obo/GO_0005506
• tetrahydrobiopterin metabolic process
  http://purl.obolibrary.org/obo/GO_0046146
• oxidation-reduction process
  http://purl.obolibrary.org/obo/GO_0055114
• monooxygenase activity
  http://purl.obolibrary.org/obo/GO_0004497
• tyrosine biosynthetic process
  http://purl.obolibrary.org/obo/GO_0006571
• L-phenylalanine catabolic process
  http://purl.obolibrary.org/obo/GO_0006559
• cofactor binding
  http://purl.obolibrary.org/obo/GO_0048037
• oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
  http://purl.obolibrary.org/obo/GO_0016714
• protein hydroxylation
  http://purl.obolibrary.org/obo/GO_0018126
• oxidoreductase activity
  http://purl.obolibrary.org/obo/GO_0016491
• amino acid binding
  http://purl.obolibrary.org/obo/GO_0016597
• protein homodimerization activity
  http://purl.obolibrary.org/obo/GO_0042803
• phenylalanine 4-monooxygenase activity
  http://purl.obolibrary.org/obo/GO_0004505
• pteridine-containing compound metabolic process
  http://purl.obolibrary.org/obo/GO_0042558
• metabolic process
  http://purl.obolibrary.org/obo/GO_0008152
• metal ion binding
  http://purl.obolibrary.org/obo/GO_0046872

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map01100
• http://www.genome.jp/dbget-bin/www_bget?map00360
• http://www.genome.jp/dbget-bin/www_bget?map00400

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• tyrosine and tryptophan biosynthesis
• Metabolic pathways
• Phenylalanine metabolism
• Phenylalanine