Brain Transcriptome Database (BrainTx)
トランスクリプトームデータ
CD43816
http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD43816
CD43816(トランスクリプトームデータ)
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CD43816
トランスクリプトームデータ
遺伝子シンボル
http://metadb.riken.jp/db/BrainTx/geneSymbol
Smad3
遺伝子名
http://metadb.riken.jp/db/BrainTx/geneName
MAD homolog 3 (Drosophila)
別名
http://metadb.riken.jp/db/BrainTx/alt_name
SMAD family member 3
mothers against DPP homolog 3
mad3
MAD homolog 3 (Drosophila)
mMad3
mothers against decapentaplegic homolog 3
別名略称
http://metadb.riken.jp/db/BrainTx/alt_symbol
AU022421
Smad 3
Madh3
NCBI遺伝子
http://metadb.riken.jp/db/BrainTx/NCBIGene
https://www.ncbi.nlm.nih.gov/gene/17127
MGI遺伝子
http://metadb.riken.jp/db/BrainTx/mgiGene
SMAD family member 3
http://metadb.riken.jp/db/mgi_rdf/MGI:1201674
BrainTx遺伝子
http://metadb.riken.jp/db/BrainTx/brainTxGene
脳発現画像
http://metadb.riken.jp/db/BrainTx/brainExpressionImage
時系列発現 (小脳)
http://metadb.riken.jp/db/BrainTx/brainExpression
脳発現特異性/組織別発現
http://metadb.riken.jp/db/BrainTx/brainSpecificity
BrainTx遺伝子カテゴリー
http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory
NCBI Accession Number
http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber
https://www.ncbi.nlm.nih.gov/nuccore/NM_016769
Ensembl 遺伝子
http://metadb.riken.jp/db/BrainTx/ensemblGene
http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000032402
UniGene 遺伝子
http://metadb.riken.jp/db/BrainTx/uniGene
https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.7320
OMIM ID
http://metadb.riken.jp/db/BrainTx/omim
https://www.omim.org/entry/603434?search=603434&highlight=603109
PubMed ID (PMID)
http://rdf.ncbi.nlm.nih.gov/pubmed/
J. Massagué, TGF-beta signal transduction., Annual review of biochemistry, 1998, 67
http://rdf.ncbi.nlm.nih.gov/pubmed/9759503
Y. Zhang, et.al., Receptor-associated Mad homologues synergize as effectors of the TGF-beta response., Nature, 1996, 383
http://rdf.ncbi.nlm.nih.gov/pubmed/8774881
Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
J. Zhao, et.al., Abrogation of Smad3 and Smad2 or of Smad4 gene expression positively regulates murine embryonic lung branching morphogenesis in culture., Developmental biology, 1998, 194
http://rdf.ncbi.nlm.nih.gov/pubmed/9501027
Chek Kun. Tan, et.al., Smad3 deficiency in mice protects against insulin resistance and obesity induced by a high-fat diet., Diabetes, 2011, 60
http://rdf.ncbi.nlm.nih.gov/pubmed/21270259
E. Labbé, et.al., Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2., Molecular cell, 1998, 2
http://rdf.ncbi.nlm.nih.gov/pubmed/9702197
Hiroyuki. Enomoto, et.al., Cooperation of two ADAMTS metalloproteases in closure of the mouse palate identifies a requirement for versican proteolysis in regulating palatal mesenchyme proliferation., Development (Cambridge, England), 2010, 137
http://rdf.ncbi.nlm.nih.gov/pubmed/21041365
Xaralabos. Varelas, et.al., The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway., Developmental cell, 2010, 19
http://rdf.ncbi.nlm.nih.gov/pubmed/21145499
Y. Zhu, et.al., Smad3 mutant mice develop metastatic colorectal cancer., Cell, 1998, 94
http://rdf.ncbi.nlm.nih.gov/pubmed/9753318
Martin. Giroux, et.al., SMAD3 prevents graft-versus-host disease by restraining Th1 differentiation and granulocyte-mediated tissue damage., Blood, 2011, 117
http://rdf.ncbi.nlm.nih.gov/pubmed/21119112
Gene Ontology
http://metadb.riken.jp/db/BrainTx/golink
chromatin DNA binding
http://purl.obolibrary.org/obo/GO_0031490
negative regulation of cell proliferation
http://purl.obolibrary.org/obo/GO_0008285
chromatin binding
http://purl.obolibrary.org/obo/GO_0003682
transdifferentiation
http://purl.obolibrary.org/obo/GO_0060290
macromolecular complex
http://purl.obolibrary.org/obo/GO_0032991
somitogenesis
http://purl.obolibrary.org/obo/GO_0001756
core promoter proximal region sequence-specific DNA binding
http://purl.obolibrary.org/obo/GO_0000987
lens fiber cell differentiation
http://purl.obolibrary.org/obo/GO_0070306
positive regulation of positive chemotaxis
http://purl.obolibrary.org/obo/GO_0050927
collagen binding
http://purl.obolibrary.org/obo/GO_0005518
pericardium development
http://purl.obolibrary.org/obo/GO_0060039
transport
http://purl.obolibrary.org/obo/GO_0006810
regulation of epithelial cell proliferation
http://purl.obolibrary.org/obo/GO_0050678
nucleus
http://purl.obolibrary.org/obo/GO_0005634
beta-catenin binding
http://purl.obolibrary.org/obo/GO_0008013
ubiquitin binding
http://purl.obolibrary.org/obo/GO_0043130
metal ion binding
http://purl.obolibrary.org/obo/GO_0046872
positive regulation of stress fiber assembly
http://purl.obolibrary.org/obo/GO_0051496
plasma membrane
http://purl.obolibrary.org/obo/GO_0005886
in utero embryonic development
http://purl.obolibrary.org/obo/GO_0001701
positive regulation of focal adhesion assembly
http://purl.obolibrary.org/obo/GO_0051894
developmental growth
http://purl.obolibrary.org/obo/GO_0048589
sequence-specific DNA binding transcription factor activity
http://purl.obolibrary.org/obo/GO_0003700
transforming growth factor beta receptor signaling pathway
http://purl.obolibrary.org/obo/GO_0007179
regulation of transforming growth factor beta receptor signaling pathway
http://purl.obolibrary.org/obo/GO_0017015
cell-cell junction organization
http://purl.obolibrary.org/obo/GO_0045216
transcription factor binding
http://purl.obolibrary.org/obo/GO_0008134
gastrulation
http://purl.obolibrary.org/obo/GO_0007369
embryonic cranial skeleton morphogenesis
http://purl.obolibrary.org/obo/GO_0048701
activation of pro-apoptotic gene products
http://purl.obolibrary.org/obo/GO_0008633
protein homodimerization activity
http://purl.obolibrary.org/obo/GO_0042803
osteoblast differentiation
http://purl.obolibrary.org/obo/GO_0001649
positive regulation of canonical Wnt signaling pathway
http://purl.obolibrary.org/obo/GO_0090263
release of cytochrome c from mitochondria
http://purl.obolibrary.org/obo/GO_0001836
embryonic foregut morphogenesis
http://purl.obolibrary.org/obo/GO_0048617
immune response
http://purl.obolibrary.org/obo/GO_0006955
activation of cysteine-type endopeptidase activity involved in apoptotic process
http://purl.obolibrary.org/obo/GO_0006919
paraxial mesoderm morphogenesis
http://purl.obolibrary.org/obo/GO_0048340
thyroid gland development
http://purl.obolibrary.org/obo/GO_0030878
liver development
http://purl.obolibrary.org/obo/GO_0001889
cell cycle arrest
http://purl.obolibrary.org/obo/GO_0007050
cytoplasm
http://purl.obolibrary.org/obo/GO_0005737
co-SMAD binding
http://purl.obolibrary.org/obo/GO_0070410
apoptotic process
http://purl.obolibrary.org/obo/GO_0006915
nuclear inner membrane
http://purl.obolibrary.org/obo/GO_0005637
positive regulation of transcription, DNA-templated
http://purl.obolibrary.org/obo/GO_0045893
negative regulation of transcription from RNA polymerase II promoter
http://purl.obolibrary.org/obo/GO_0000122
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
http://purl.obolibrary.org/obo/GO_0043280
protein kinase binding
http://purl.obolibrary.org/obo/GO_0019901
heart looping
http://purl.obolibrary.org/obo/GO_0001947
transforming growth factor beta receptor binding
http://purl.obolibrary.org/obo/GO_0005160
receptor complex
http://purl.obolibrary.org/obo/GO_0043235
positive regulation of transcription from RNA polymerase II promoter
http://purl.obolibrary.org/obo/GO_0045944
regulation of striated muscle tissue development
http://purl.obolibrary.org/obo/GO_0016202
SMAD protein complex
http://purl.obolibrary.org/obo/GO_0071141
transcription factor complex
http://purl.obolibrary.org/obo/GO_0005667
mesoderm formation
http://purl.obolibrary.org/obo/GO_0001707
positive regulation of interleukin-1 beta production
http://purl.obolibrary.org/obo/GO_0032731
ubiquitin protein ligase binding
http://purl.obolibrary.org/obo/GO_0031625
protein binding
http://purl.obolibrary.org/obo/GO_0005515
zinc ion binding
http://purl.obolibrary.org/obo/GO_0008270
regulation of transforming growth factor beta2 production
http://purl.obolibrary.org/obo/GO_0032909
SMAD protein complex assembly
http://purl.obolibrary.org/obo/GO_0007183
evasion or tolerance of host defenses by virus
http://purl.obolibrary.org/obo/GO_0019049
sequence-specific DNA binding
http://purl.obolibrary.org/obo/GO_0043565
negative regulation of inflammatory response
http://purl.obolibrary.org/obo/GO_0050728
RNA polymerase II activating transcription factor binding
http://purl.obolibrary.org/obo/GO_0001102
transcription, DNA-templated
http://purl.obolibrary.org/obo/GO_0006351
negative regulation of cell growth
http://purl.obolibrary.org/obo/GO_0030308
transcription regulatory region DNA binding
http://purl.obolibrary.org/obo/GO_0044212
response to hypoxia
http://purl.obolibrary.org/obo/GO_0001666
immune system development
http://purl.obolibrary.org/obo/GO_0002520
negative regulation of mitotic cell cycle
http://purl.obolibrary.org/obo/GO_0045930
transcription from RNA polymerase II promoter
http://purl.obolibrary.org/obo/GO_0006366
intracellular
http://purl.obolibrary.org/obo/GO_0005622
SMAD binding
http://purl.obolibrary.org/obo/GO_0046332
negative regulation of osteoblast proliferation
http://purl.obolibrary.org/obo/GO_0033689
negative regulation of apoptotic process
http://purl.obolibrary.org/obo/GO_0043066
regulation of transcription, DNA-templated
http://purl.obolibrary.org/obo/GO_0006355
endoderm development
http://purl.obolibrary.org/obo/GO_0007492
double-stranded DNA binding
http://purl.obolibrary.org/obo/GO_0003690
activation of cysteine-type endopeptidase activity
http://purl.obolibrary.org/obo/GO_0097202
negative regulation of protein phosphorylation
http://purl.obolibrary.org/obo/GO_0001933
osteoblast development
http://purl.obolibrary.org/obo/GO_0002076
positive regulation of epithelial to mesenchymal transition
http://purl.obolibrary.org/obo/GO_0010718
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
http://purl.obolibrary.org/obo/GO_0030618
negative regulation of wound healing
http://purl.obolibrary.org/obo/GO_0061045
T cell activation
http://purl.obolibrary.org/obo/GO_0042110
positive regulation of cell migration
http://purl.obolibrary.org/obo/GO_0030335
regulation of binding
http://purl.obolibrary.org/obo/GO_0051098
regulation of immune response
http://purl.obolibrary.org/obo/GO_0050776
negative regulation of protein catabolic process
http://purl.obolibrary.org/obo/GO_0042177
apoptotic mitochondrial changes
http://purl.obolibrary.org/obo/GO_0008637
protein stabilization
http://purl.obolibrary.org/obo/GO_0050821
R-SMAD binding
http://purl.obolibrary.org/obo/GO_0070412
positive regulation of chondrocyte differentiation
http://purl.obolibrary.org/obo/GO_0032332
phosphatase binding
http://purl.obolibrary.org/obo/GO_0019902
positive regulation of transforming growth factor beta3 production
http://purl.obolibrary.org/obo/GO_0032916
positive regulation of alkaline phosphatase activity
http://purl.obolibrary.org/obo/GO_0010694
negative regulation of osteoblast differentiation
http://purl.obolibrary.org/obo/GO_0045668
DNA binding
http://purl.obolibrary.org/obo/GO_0003677
skeletal system development
http://purl.obolibrary.org/obo/GO_0001501
embryonic pattern specification
http://purl.obolibrary.org/obo/GO_0009880
positive regulation of bone mineralization
http://purl.obolibrary.org/obo/GO_0030501
InterPro ID
http://metadb.riken.jp/db/BrainTx/interPro
KEGG Pathway ID
http://metadb.riken.jp/db/BrainTx/keggPathwayID
http://www.genome.jp/dbget-bin/www_bget?map05166
http://www.genome.jp/dbget-bin/www_bget?map04110
http://www.genome.jp/dbget-bin/www_bget?map04520
http://www.genome.jp/dbget-bin/www_bget?map05200
http://www.genome.jp/dbget-bin/www_bget?map05212
http://www.genome.jp/dbget-bin/www_bget?map04310
http://www.genome.jp/dbget-bin/www_bget?map04350
http://www.genome.jp/dbget-bin/www_bget?map04144
http://www.genome.jp/dbget-bin/www_bget?map05142
http://www.genome.jp/dbget-bin/www_bget?map05220
http://www.genome.jp/dbget-bin/www_bget?map05210
KEGG Pathway 名称
http://metadb.riken.jp/db/BrainTx/keggPathwayName
Wnt signaling pathway
Pancreatic cancer
TGF-beta signaling pathway
Colorectal cancer
Pathways in cancer
Endocytosis
Adherens junction
Cell cycle
HTLV-I infection
Chagas disease (American trypanosomiasis)
Chronic myeloid leukemia
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