CD48378

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD48378

CD48378

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Adora2a

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• adenosine A2a receptor

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• A2a, Rs
• adenosine receptor A2a
• adenosine A2a receptor

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• A2aR
• A2a
• AA2AR
• A2AAR
• Rs

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/11540

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• adenosine A2a receptor
  http://metadb.riken.jp/db/mgi_rdf/MGI:99402

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_009630

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000020178

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.333734

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=102776

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• F. Coppée, et.al., Early occurrence of metastatic differentiated thyroid carcinomas in transgenic mice expressing the A2a adenosine receptor gene and the human papillomavirus type 16 E7 oncogene., Oncogene, 1996, 13
  http://rdf.ncbi.nlm.nih.gov/pubmed/8875985
• Stéphane. Mievis, et.al., A2A receptor knockout worsens survival and motor behaviour in a transgenic mouse model of Huntington's disease., Neurobiology of disease, 2011, 41
  http://rdf.ncbi.nlm.nih.gov/pubmed/21062644
• Mattias. Enoksson, et.al., Mast cells as sensors of cell injury through IL-33 recognition., Journal of immunology (Baltimore, Md. : 1950), 2011, 186
  http://rdf.ncbi.nlm.nih.gov/pubmed/21239713
• Yujin. Zhang, et.al., Detrimental effects of adenosine signaling in sickle cell disease., Nature medicine, 2011, 17
  http://rdf.ncbi.nlm.nih.gov/pubmed/21170046
• C. Ledent, et.al., Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor., Nature, 1997, 388
  http://rdf.ncbi.nlm.nih.gov/pubmed/9262401
• Veronica J. Chehata, et.al., Adenosine A(2A) receptor activation limits chronic granulomatous disease-induced hyperinflammation., Cellular immunology, 2011, 267
  http://rdf.ncbi.nlm.nih.gov/pubmed/21130984
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• D L. Marquardt, et.al., Cloning of two adenosine receptor subtypes from mouse bone marrow-derived mast cells., Journal of immunology (Baltimore, Md. : 1950), 1994, 152
  http://rdf.ncbi.nlm.nih.gov/pubmed/8157966
• F. Noble, et.al., Differences among mouse strains in the regulation by mu, delta 1 and delta 2 opioid receptors of striatal adenylyl cyclases activated by dopamine D1 or adenosine A2a receptors., Brain research, 1996, 716
  http://rdf.ncbi.nlm.nih.gov/pubmed/8738226
• J H. Stehle, et.al., Molecular cloning and expression of the cDNA for a novel A2-adenosine receptor subtype., Molecular endocrinology (Baltimore, Md.), 1992, 6
  http://rdf.ncbi.nlm.nih.gov/pubmed/1584214

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• locomotory behavior
  http://purl.obolibrary.org/obo/GO_0007626
• intracellular
  http://purl.obolibrary.org/obo/GO_0005622
• protein kinase C-activating G-protein coupled receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0007205
• alpha-actinin binding
  http://purl.obolibrary.org/obo/GO_0051393
• positive regulation of synaptic transmission, glutamatergic
  http://purl.obolibrary.org/obo/GO_0051968
• membrane depolarization
  http://purl.obolibrary.org/obo/GO_0051899
• plasma membrane
  http://purl.obolibrary.org/obo/GO_0005886
• eating behavior
  http://purl.obolibrary.org/obo/GO_0042755
• presynaptic active zone
  http://purl.obolibrary.org/obo/GO_0048786
• positive regulation of urine volume
  http://purl.obolibrary.org/obo/GO_0035810
• regulation of transcription, DNA-templated
  http://purl.obolibrary.org/obo/GO_0006355
• G-protein coupled adenosine receptor activity
  http://purl.obolibrary.org/obo/GO_0001609
• negative regulation of alpha-beta T cell activation
  http://purl.obolibrary.org/obo/GO_0046636
• synaptic transmission, cholinergic
  http://purl.obolibrary.org/obo/GO_0007271
• adenosine receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0001973
• synaptic transmission, dopaminergic
  http://purl.obolibrary.org/obo/GO_0001963
• axolemma
  http://purl.obolibrary.org/obo/GO_0030673
• intracellular organelle part
  http://purl.obolibrary.org/obo/GO_0044446
• integral component of membrane
  http://purl.obolibrary.org/obo/GO_0016021
• protein heterodimerization activity
  http://purl.obolibrary.org/obo/GO_0046982
• signal transducer activity
  http://purl.obolibrary.org/obo/GO_0004871
• negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
  http://purl.obolibrary.org/obo/GO_0043154
• prepulse inhibition
  http://purl.obolibrary.org/obo/GO_0060134
• presynaptic membrane
  http://purl.obolibrary.org/obo/GO_0042734
• positive regulation of cAMP biosynthetic process
  http://purl.obolibrary.org/obo/GO_0030819
• neuron projection morphogenesis
  http://purl.obolibrary.org/obo/GO_0048812
• synaptic transmission, glutamatergic
  http://purl.obolibrary.org/obo/GO_0035249
• negative regulation of neuron apoptotic process
  http://purl.obolibrary.org/obo/GO_0043524
• positive regulation of synaptic transmission, GABAergic
  http://purl.obolibrary.org/obo/GO_0032230
• asymmetric synapse
  http://purl.obolibrary.org/obo/GO_0032279
• positive regulation of renal sodium excretion
  http://purl.obolibrary.org/obo/GO_0035815
• negative regulation of vascular permeability
  http://purl.obolibrary.org/obo/GO_0043116
• response to caffeine
  http://purl.obolibrary.org/obo/GO_0031000
• negative regulation of locomotion
  http://purl.obolibrary.org/obo/GO_0040013
• enzyme binding
  http://purl.obolibrary.org/obo/GO_0019899
• membrane fraction
  http://purl.obolibrary.org/obo/GO_0005624
• positive regulation of protein secretion
  http://purl.obolibrary.org/obo/GO_0050714
• regulation of calcium ion transport via voltage-gated calcium channel activity
  http://purl.obolibrary.org/obo/GO_0051925
• negative regulation of inflammatory response
  http://purl.obolibrary.org/obo/GO_0050728
• endomembrane system
  http://purl.obolibrary.org/obo/GO_0012505
• postsynaptic membrane
  http://purl.obolibrary.org/obo/GO_0045211
• membrane
  http://purl.obolibrary.org/obo/GO_0016020
• regulation of synaptic plasticity
  http://purl.obolibrary.org/obo/GO_0048167
• vasodilation
  http://purl.obolibrary.org/obo/GO_0042311
• response to amphetamine
  http://purl.obolibrary.org/obo/GO_0001975
• negative regulation of protein kinase activity
  http://purl.obolibrary.org/obo/GO_0006469
• negative regulation of cell proliferation
  http://purl.obolibrary.org/obo/GO_0008285
• intermediate filament
  http://purl.obolibrary.org/obo/GO_0005882
• induction of apoptosis in response to chemical stimulus
  http://purl.obolibrary.org/obo/GO_0031558
• positive regulation of glutamate secretion
  http://purl.obolibrary.org/obo/GO_0014049
• dendrite
  http://purl.obolibrary.org/obo/GO_0030425
• cargo receptor activity
  http://purl.obolibrary.org/obo/GO_0038024
• astrocyte activation
  http://purl.obolibrary.org/obo/GO_0048143
• G-protein coupled receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0007186
• type 5 metabotropic glutamate receptor binding
  http://purl.obolibrary.org/obo/GO_0031802
• regulation of mitochondrial membrane potential
  http://purl.obolibrary.org/obo/GO_0051881
• postsynaptic density
  http://purl.obolibrary.org/obo/GO_0014069
• response to alkaloid
  http://purl.obolibrary.org/obo/GO_0043279
• adenylate cyclase-activating G-protein coupled receptor signaling pathway
  http://purl.obolibrary.org/obo/GO_0007189
• G-protein coupled receptor activity
  http://purl.obolibrary.org/obo/GO_0004930
• neuronal cell body
  http://purl.obolibrary.org/obo/GO_0043025
• signal transduction
  http://purl.obolibrary.org/obo/GO_0007165
• regulation of norepinephrine secretion
  http://purl.obolibrary.org/obo/GO_0014061
• axon
  http://purl.obolibrary.org/obo/GO_0030424
• signaling receptor activity
  http://purl.obolibrary.org/obo/GO_0038023

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map04020
• http://www.genome.jp/dbget-bin/www_bget?map04080
• http://www.genome.jp/dbget-bin/www_bget?map04270

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Vascular smooth muscle contraction
• Calcium signaling pathway
• Neuroactive ligand-receptor interaction