Michael A. Arnold, et.al., MEF2C transcription factor controls chondrocyte hypertrophy and bone development., Developmental cell, 2007, 12

http://rdf.ncbi.nlm.nih.gov/pubmed/17336904

Michael A. Arnold, et.al., MEF2C transcription factor controls chondrocyte hypertrophy and bone development., Developmental cell, 2007, 12

http://rdf.ncbi.nlm.nih.gov/pubmed/

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD18782
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD18782

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(Col2a1-Mef2c/VP16)1Eno
  http://metadb.riken.jp/db/mgi_rdf/MGI:3719002
• Mef2d<tm1Eno>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3718322
• Mef2d<tm1.1Eno>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3718328
• Mef2c<tm2Eno>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3718323
• Tg(Col2a1-Mef2c/en)1Eno
  http://metadb.riken.jp/db/mgi_rdf/MGI:3718996

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• short limbs_Tg(Col2a1-Mef2c/en)1Eno/0
  http://metadb.riken.jp/0000547NSTgCol2a1Mef2cen1Eno0TgCol2a1Mef2cen1Eno
• neonatal lethality, complete penetrance_Mef2c<tm1Eno>/Mef2c<+>,Mef2d<tm1.1Eno>/Mef2d<+>
  http://metadb.riken.jp/0011087I129S7SvEvBrdMef2ctm1EnoMef2cMef2dtm11EnoMef2dMef2dMef2cMef2dtm11EnoMef2ctm1Eno
• decreased length of long bones_Mef2c<tm1Eno>/Mef2c<tm2Eno>,Tg(Col2a1-cre)1Bhr/0
  http://metadb.riken.jp/0004686I129SSvEv129S7SvEvBrdC57BL6SJLMef2ctm1EnoMef2ctm2EnoTgCol2a1cre1Bhr0Mef2ctm2EnoMef2ctm1EnoTgCol2a1cre1Bhr
• short tibia_Mef2c<tm1Eno>/Mef2c<tm2Eno>,Twist2<tm1(cre)Dor>/Twist2<+>
  http://metadb.riken.jp/0002764I129SSvEv129S7SvEvBrd129X1SvJMef2ctm1EnoMef2ctm2EnoTwist2tm1creDorTwist2Twist2tm1creDorMef2ctm2EnoTwist2Mef2ctm1Eno
• failure of endochondral bone ossification_Mef2c<tm2Eno>/Mef2c<tm2Eno>,Mef2d<tm1Eno>/Mef2d<tm1Eno>,Tg(Col2a1-cre)1Bhr/0
  http://metadb.riken.jp/0008275I129SSvEvC57BL6SJLMef2ctm2EnoMef2ctm2EnoMef2dtm1EnoMef2dtm1EnoTgCol2a1cre1Bhr0TgCol2a1cre1BhrMef2dtm1EnoMef2ctm2Eno
• failure of sternum ossification_Mef2c<tm1Eno>/Mef2c<+>
  http://metadb.riken.jp/0008278I129S7SvEvBrdMef2ctm1EnoMef2cMef2ctm1EnoMef2c
• abnormal thoracic cage morphology_Tg(Col2a1-Mef2c/en)1Eno/0
  http://metadb.riken.jp/0004624NSTgCol2a1Mef2cen1Eno0TgCol2a1Mef2cen1Eno
• abnormal endochondral bone ossification_Mef2c<tm1Eno>/Mef2c<tm2Eno>,Tg(Col2a1-cre)1Bhr/0
  http://metadb.riken.jp/0008272I129SSvEv129S7SvEvBrdC57BL6SJLMef2ctm1EnoMef2ctm2EnoTgCol2a1cre1Bhr0Mef2ctm2EnoMef2ctm1EnoTgCol2a1cre1Bhr
• abnormal neurocranium morphology_Tg(Col2a1-Mef2c/VP16)1Eno/0
  http://metadb.riken.jp/0000074NSTgCol2a1Mef2cVP161Eno0TgCol2a1Mef2cVP161Eno
• abnormal endochondral bone ossification_Mef2c<tm1Eno>/Mef2c<tm2Eno>,Twist2<tm1(cre)Dor>/Twist2<+>
  http://metadb.riken.jp/0008272I129SSvEv129S7SvEvBrd129X1SvJMef2ctm1EnoMef2ctm2EnoTwist2tm1creDorTwist2Twist2tm1creDorMef2ctm2EnoTwist2Mef2ctm1Eno
• failure of sternum ossification_Mef2c<tm1Eno>/Mef2c<+>,Mef2d<tm1.1Eno>/Mef2d<+>
  http://metadb.riken.jp/0008278I129S7SvEvBrdMef2ctm1EnoMef2cMef2dtm11EnoMef2dMef2dMef2cMef2dtm11EnoMef2ctm1Eno
• abnormal gait_Mef2c<tm1Eno>/Mef2c<tm2Eno>,Tg(Col2a1-cre)1Bhr/0
  http://metadb.riken.jp/0001406I129SSvEv129S7SvEvBrdC57BL6SJLMef2ctm1EnoMef2ctm2EnoTgCol2a1cre1Bhr0Mef2ctm2EnoMef2ctm1EnoTgCol2a1cre1Bhr
• abnormal trabecular bone morphology_Mef2c<tm1Eno>/Mef2c<tm2Eno>,Twist2<tm1(cre)Dor>/Twist2<+>
  http://metadb.riken.jp/0000130I129SSvEv129S7SvEvBrd129X1SvJMef2ctm1EnoMef2ctm2EnoTwist2tm1creDorTwist2Twist2tm1creDorMef2ctm2EnoTwist2Mef2ctm1Eno
• respiratory distress_Mef2c<tm1Eno>/Mef2c<tm2Eno>,Twist2<tm1(cre)Dor>/Twist2<+>
  http://metadb.riken.jp/0001954I129SSvEv129S7SvEvBrd129X1SvJMef2ctm1EnoMef2ctm2EnoTwist2tm1creDorTwist2Twist2tm1creDorMef2ctm2EnoTwist2Mef2ctm1Eno
• short limbs_Mef2c<tm1Eno>/Mef2c<tm2Eno>,Tg(Col2a1-cre)1Bhr/0
  http://metadb.riken.jp/0000547I129SSvEv129S7SvEvBrdC57BL6SJLMef2ctm1EnoMef2ctm2EnoTgCol2a1cre1Bhr0Mef2ctm2EnoMef2ctm1EnoTgCol2a1cre1Bhr
• abnormal epiphyseal plate morphology_Tg(Col2a1-Mef2c/VP16)1Eno/0
  http://metadb.riken.jp/0006395NSTgCol2a1Mef2cVP161Eno0TgCol2a1Mef2cVP161Eno
• abnormal forelimb morphology_Tg(Col2a1-Mef2c/VP16)1Eno/0
  http://metadb.riken.jp/0000550NSTgCol2a1Mef2cVP161Eno0TgCol2a1Mef2cVP161Eno
• short vertebral column_Tg(Col2a1-Mef2c/en)1Eno/0
  http://metadb.riken.jp/0004704NSTgCol2a1Mef2cen1Eno0TgCol2a1Mef2cen1Eno
• short limbs_Tg(Col2a1-Mef2c/VP16)1Eno/0
  http://metadb.riken.jp/0000547NSTgCol2a1Mef2cVP161Eno0TgCol2a1Mef2cVP161Eno
• short limbs_Mef2c<tm1Eno>/Mef2c<tm2Eno>,Twist2<tm1(cre)Dor>/Twist2<+>
  http://metadb.riken.jp/0000547I129SSvEv129S7SvEvBrd129X1SvJMef2ctm1EnoMef2ctm2EnoTwist2tm1creDorTwist2Twist2tm1creDorMef2ctm2EnoTwist2Mef2ctm1Eno
• failure of endochondral bone ossification_Tg(Col2a1-Mef2c/en)1Eno/0
  http://metadb.riken.jp/0008275NSTgCol2a1Mef2cen1Eno0TgCol2a1Mef2cen1Eno
• premature endochondral bone ossification_Tg(Col2a1-Mef2c/VP16)1Eno/0
  http://metadb.riken.jp/0003417NSTgCol2a1Mef2cVP161Eno0TgCol2a1Mef2cVP161Eno
• postnatal lethality, complete penetrance_Mef2c<tm1Eno>/Mef2c<tm2Eno>,Twist2<tm1(cre)Dor>/Twist2<+>
  http://metadb.riken.jp/0011085I129SSvEv129S7SvEvBrd129X1SvJMef2ctm1EnoMef2ctm2EnoTwist2tm1creDorTwist2Twist2tm1creDorMef2ctm2EnoTwist2Mef2ctm1Eno
• abnormal pelvic girdle bone morphology_Tg(Col2a1-Mef2c/en)1Eno/0
  http://metadb.riken.jp/0004509NSTgCol2a1Mef2cen1Eno0TgCol2a1Mef2cen1Eno
• short fibula_Mef2c<tm1Eno>/Mef2c<tm2Eno>,Twist2<tm1(cre)Dor>/Twist2<+>
  http://metadb.riken.jp/0002765I129SSvEv129S7SvEvBrd129X1SvJMef2ctm1EnoMef2ctm2EnoTwist2tm1creDorTwist2Twist2tm1creDorMef2ctm2EnoTwist2Mef2ctm1Eno
• failure of sternum ossification_Mef2c<tm1Eno>/Mef2c<tm2Eno>,Tg(Col2a1-cre)1Bhr/0
  http://metadb.riken.jp/0008278I129SSvEv129S7SvEvBrdC57BL6SJLMef2ctm1EnoMef2ctm2EnoTgCol2a1cre1Bhr0Mef2ctm2EnoMef2ctm1EnoTgCol2a1cre1Bhr
• failure of endochondral bone ossification_Mef2c<tm1Eno>/Mef2c<tm2Eno>,Twist2<tm1(cre)Dor>/Twist2<+>
  http://metadb.riken.jp/0008275I129SSvEv129S7SvEvBrd129X1SvJMef2ctm1EnoMef2ctm2EnoTwist2tm1creDorTwist2Twist2tm1creDorMef2ctm2EnoTwist2Mef2ctm1Eno