Honghong. Sun, et.al., TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis., Cell, 2008, 133

http://rdf.ncbi.nlm.nih.gov/pubmed/18455983

Honghong. Sun, et.al., TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis., Cell, 2008, 133

http://rdf.ncbi.nlm.nih.gov/pubmed/

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD42217
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD42217

allele

http://purl.org/net/cito/citesAsAuthority

• Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3810526

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased circulating interleukin-6 level_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0008596129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn
• increased interleukin-4 secretion_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0008699129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn
• abnormal B cell activation_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0008217129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn
• increased circulating interleukin-12 level_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0008617129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn
• intestinal inflammation_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0001858129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn
• increased circulating tumor necrosis factor level_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0008553129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn
• decreased IgG2a level_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0008496129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn
• decreased IgG2b level_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0008497129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn
• increased interleukin-2 secretion_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0008687129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn
• increased circulating interleukin-10 level_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0008593129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn
• abnormal CD4-positive, alpha-beta T cell physiology_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0005463129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn
• increased T cell number_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0005015129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn
• weight loss_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0001263129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn
• abnormal spleen morphology_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0000689129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn
• abnormal cytotoxic T cell physiology_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0005078129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn
• increased spleen white pulp amount_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0008478129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn
• increased interleukin-12 secretion_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0008663129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn
• increased interleukin-1 beta secretion_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0008657129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn
• increased susceptibility to endotoxin shock_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0008735129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn
• increased B cell number_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0005014129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn
• increased tumor necrosis factor secretion_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0008560129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn
• chronic inflammation_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0002499129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn
• enlarged spleen_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0000691129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn
• lung inflammation_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0001861129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn
• abnormal macrophage activation involved in immune response_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0011075129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn
• abnormal leukocyte morphology_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0008246129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn
• increased interleukin-17 secretion_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0008681129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn
• abnormal inflammatory response_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0001845129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn
• liver inflammation_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0001860129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn
• spleen hyperplasia_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0000693129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn
• abnormal myeloid dendritic cell morphology_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0006173129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn
• increased interferon-gamma secretion_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0008566129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn
• lymph node inflammation_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0003865129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn
• increased interleukin-6 secretion_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0008705129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn
• abnormal B cell physiology_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0002459129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn
• increased circulating interleukin-1 beta level_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0008641129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn
• abnormal T cell apoptosis_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0006412129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn
• decreased survivor rate_Tnfaip8l2<tm1Yhcn>/Tnfaip8l2<tm1Yhcn>
  http://metadb.riken.jp/0008770129S6SvEvTacTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1YhcnTnfaip8l2tm1Yhcn