Joachim. Weischenfeldt, et.al., NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements., Genes & development, 2008, 22

http://rdf.ncbi.nlm.nih.gov/pubmed/18483223

Joachim. Weischenfeldt, et.al., NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements., Genes & development, 2008, 22

http://rdf.ncbi.nlm.nih.gov/pubmed/

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD28379
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD28379

allele

http://purl.org/net/cito/citesAsAuthority

• Upf2<tm1.1Btp>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3790199
• Upf2<tm1Btp>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3790198

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal common lymphocyte progenitor cell morphology_Tg(Mx1-cre)1Cgn/?,Upf2<tm1Btp>/Upf2<tm1Btp>
  http://metadb.riken.jp/0008249I129P2OlaHsdC57BL6CBATgMx1cre1CgnUpf2tm1BtpUpf2tm1BtpTgMx1cre1CgnUpf2tm1Btp
• thymus hypoplasia_Tg(Lck-cre)548Jxm/?,Upf2<tm1Btp>/Upf2<tm1Btp>
  http://metadb.riken.jp/0001823I129P2OlaHsdC57BL6CBATgLckcre548JxmUpf2tm1BtpUpf2tm1BtpUpf2tm1BtpTgLckcre548Jxm
• low mean erythrocyte cell number_Tg(Mx1-cre)1Cgn/?,Upf2<tm1Btp>/Upf2<tm1Btp>
  http://metadb.riken.jp/0002594I129P2OlaHsdC57BL6CBATgMx1cre1CgnUpf2tm1BtpUpf2tm1BtpTgMx1cre1CgnUpf2tm1Btp
• premature death_Tg(Mx1-cre)1Cgn/?,Upf2<tm1Btp>/Upf2<tm1Btp>
  http://metadb.riken.jp/0002083I129P2OlaHsdC57BL6CBATgMx1cre1CgnUpf2tm1BtpUpf2tm1BtpTgMx1cre1CgnUpf2tm1Btp
• abnormal T cell receptor beta chain V(D)J recombination_Tg(Lck-cre)548Jxm/?,Upf2<tm1Btp>/Upf2<tm1Btp>
  http://metadb.riken.jp/0008758I129P2OlaHsdC57BL6CBATgLckcre548JxmUpf2tm1BtpUpf2tm1BtpUpf2tm1BtpTgLckcre548Jxm
• decreased granulocyte number_Tg(Mx1-cre)1Cgn/?,Upf2<tm1Btp>/Upf2<tm1Btp>
  http://metadb.riken.jp/0000334I129P2OlaHsdC57BL6CBATgMx1cre1CgnUpf2tm1BtpUpf2tm1BtpTgMx1cre1CgnUpf2tm1Btp
• embryonic lethality, complete penetrance_Upf2<tm1.1Btp>/Upf2<tm1.1Btp>
  http://metadb.riken.jp/0011092I129P2OlaHsdUpf2tm11BtpUpf2tm11BtpUpf2tm11Btp
• decreased hemoglobin content_Tg(Mx1-cre)1Cgn/?,Upf2<tm1Btp>/Upf2<tm1Btp>
  http://metadb.riken.jp/0002874I129P2OlaHsdC57BL6CBATgMx1cre1CgnUpf2tm1BtpUpf2tm1BtpTgMx1cre1CgnUpf2tm1Btp
• decreased T cell proliferation_Tg(Mx1-cre)1Cgn/?,Upf2<tm1Btp>/Upf2<tm1Btp>
  http://metadb.riken.jp/0005095I129P2OlaHsdC57BL6CBATgMx1cre1CgnUpf2tm1BtpUpf2tm1BtpTgMx1cre1CgnUpf2tm1Btp
• decreased hematocrit_Tg(Mx1-cre)1Cgn/?,Upf2<tm1Btp>/Upf2<tm1Btp>
  http://metadb.riken.jp/0000208I129P2OlaHsdC57BL6CBATgMx1cre1CgnUpf2tm1BtpUpf2tm1BtpTgMx1cre1CgnUpf2tm1Btp
• decreased CD8-positive, alpha-beta T cell number_Tg(Lck-cre)548Jxm/?,Upf2<tm1Btp>/Upf2<tm1Btp>
  http://metadb.riken.jp/0008079I129P2OlaHsdC57BL6CBATgLckcre548JxmUpf2tm1BtpUpf2tm1BtpUpf2tm1BtpTgLckcre548Jxm
• decreased hematopoietic stem cell number_Tg(Mx1-cre)1Cgn/?,Upf2<tm1Btp>/Upf2<tm1Btp>
  http://metadb.riken.jp/0004810I129P2OlaHsdC57BL6CBATgMx1cre1CgnUpf2tm1BtpUpf2tm1BtpTgMx1cre1CgnUpf2tm1Btp
• anemia_Tg(Mx1-cre)1Cgn/?,Upf2<tm1Btp>/Upf2<tm1Btp>
  http://metadb.riken.jp/0001577I129P2OlaHsdC57BL6CBATgMx1cre1CgnUpf2tm1BtpUpf2tm1BtpTgMx1cre1CgnUpf2tm1Btp
• abnormal bone marrow cell morphology/development_Tg(Mx1-cre)1Cgn/?,Upf2<tm1Btp>/Upf2<tm1Btp>
  http://metadb.riken.jp/0002398I129P2OlaHsdC57BL6CBATgMx1cre1CgnUpf2tm1BtpUpf2tm1BtpTgMx1cre1CgnUpf2tm1Btp
• abnormal B cell number_Tg(Mx1-cre)1Cgn/?,Upf2<tm1Btp>/Upf2<tm1Btp>
  http://metadb.riken.jp/0002458I129P2OlaHsdC57BL6CBATgMx1cre1CgnUpf2tm1BtpUpf2tm1BtpTgMx1cre1CgnUpf2tm1Btp
• decreased CD4-positive, alpha beta T cell number_Tg(Lck-cre)548Jxm/?,Upf2<tm1Btp>/Upf2<tm1Btp>
  http://metadb.riken.jp/0008075I129P2OlaHsdC57BL6CBATgLckcre548JxmUpf2tm1BtpUpf2tm1BtpUpf2tm1BtpTgLckcre548Jxm
• decreased double-positive T cell number_Tg(Lck-cre)548Jxm/?,Upf2<tm1Btp>/Upf2<tm1Btp>
  http://metadb.riken.jp/0005092I129P2OlaHsdC57BL6CBATgLckcre548JxmUpf2tm1BtpUpf2tm1BtpUpf2tm1BtpTgLckcre548Jxm