Nobuhiro. Kamiya, et.al., BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway., Development (Cambridge, England), 2008, 135

http://rdf.ncbi.nlm.nih.gov/pubmed/18927151

Nobuhiro. Kamiya, et.al., BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway., Development (Cambridge, England), 2008, 135

http://rdf.ncbi.nlm.nih.gov/pubmed/

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD12770
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD12770

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(CAG-lacZ,-BMPR1A*,-EGFP)1Mis
  http://metadb.riken.jp/db/mgi_rdf/MGI:3829221
• Tg(Col1a1-cre/Esr1*)1Mis
  http://metadb.riken.jp/db/mgi_rdf/MGI:3829219

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal osteoclast differentiation_Bmpr1a<tm2.1Bhr>/Bmpr1a<tm2.1Bhr>,Tg(Col1a1-cre/Esr1*)1Mis/0
  http://metadb.riken.jp/0008396I129S7SvEvBrdBmpr1atm21BhrBmpr1atm21BhrTgCol1a1creEsr11Mis0Bmpr1atm21BhrTgCol1a1creEsr11Mis
• increased bone mineralization_Bmpr1a<tm2.1Bhr>/Bmpr1a<tm2.1Bhr>,Tg(Col1a1-cre/Esr1*)1Mis/0
  http://metadb.riken.jp/0020080I129S7SvEvBrdBmpr1atm21BhrBmpr1atm21BhrTgCol1a1creEsr11Mis0Bmpr1atm21BhrTgCol1a1creEsr11Mis
• enlarged parietal bone_Bmpr1a<tm2.1Bhr>/Bmpr1a<tm2.1Bhr>,Tg(Col1a1-cre/Esr1*)1Mis/0
  http://metadb.riken.jp/0004421I129S7SvEvBrdBmpr1atm21BhrBmpr1atm21BhrTgCol1a1creEsr11Mis0Bmpr1atm21BhrTgCol1a1creEsr11Mis
• decreased bone ossification_Bmpr1a<tm2.1Bhr>/Bmpr1a<tm2.1Bhr>,Tg(Col1a1-cre/Esr1*)1Mis/0
  http://metadb.riken.jp/0020040I129S7SvEvBrdBmpr1atm21BhrBmpr1atm21BhrTgCol1a1creEsr11Mis0Bmpr1atm21BhrTgCol1a1creEsr11Mis
• abnormal osteoclast physiology_Bmpr1a<tm2.1Bhr>/Bmpr1a<tm2.1Bhr>,Tg(Col1a1-cre/Esr1*)1Mis/0
  http://metadb.riken.jp/0001541I129S7SvEvBrdBmpr1atm21BhrBmpr1atm21BhrTgCol1a1creEsr11Mis0Bmpr1atm21BhrTgCol1a1creEsr11Mis
• increased bone mass_Bmpr1a<tm2.1Bhr>/Bmpr1a<tm2.1Bhr>,Tg(Col1a1-cre/Esr1*)1Mis/0
  http://metadb.riken.jp/0005605I129S7SvEvBrdBmpr1atm21BhrBmpr1atm21BhrTgCol1a1creEsr11Mis0Bmpr1atm21BhrTgCol1a1creEsr11Mis
• decreased osteoclast cell number_Bmpr1a<tm2.1Bhr>/Bmpr1a<tm2.1Bhr>,Tg(Col1a1-cre/Esr1*)1Mis/0
  http://metadb.riken.jp/0004985I129S7SvEvBrdBmpr1atm21BhrBmpr1atm21BhrTgCol1a1creEsr11Mis0Bmpr1atm21BhrTgCol1a1creEsr11Mis
• decreased bone mass_Tg(CAG-lacZ,-BMPR1A*,-EGFP)1Mis/0,Tg(Col1a1-cre/Esr1*)1Mis/0
  http://metadb.riken.jp/0004016NSTgCAGlacZBMPR1AEGFP1Mis0TgCol1a1creEsr11Mis0TgCAGlacZBMPR1AEGFP1MisTgCol1a1creEsr11Mis
• abnormal bone structure_Bmpr1a<tm2.1Bhr>/Bmpr1a<tm2.1Bhr>,Tg(Col1a1-cre/Esr1*)1Mis/0
  http://metadb.riken.jp/0003795I129S7SvEvBrdBmpr1atm21BhrBmpr1atm21BhrTgCol1a1creEsr11Mis0Bmpr1atm21BhrTgCol1a1creEsr11Mis
• abnormal neurocranium morphology_Tg(CAG-lacZ,-BMPR1A*,-EGFP)1Mis/0,Tg(Col1a1-cre/Esr1*)1Mis/0
  http://metadb.riken.jp/0000074NSTgCAGlacZBMPR1AEGFP1Mis0TgCol1a1creEsr11Mis0TgCAGlacZBMPR1AEGFP1MisTgCol1a1creEsr11Mis
• abnormal skeleton morphology_Bmpr1a<tm2.1Bhr>/Bmpr1a<tm2.1Bhr>,Tg(Col1a1-cre/Esr1*)1Mis/0
  http://metadb.riken.jp/0005508I129S7SvEvBrdBmpr1atm21BhrBmpr1atm21BhrTgCol1a1creEsr11Mis0Bmpr1atm21BhrTgCol1a1creEsr11Mis
• abnormal skeleton physiology_Bmpr1a<tm2.1Bhr>/Bmpr1a<tm2.1Bhr>,Tg(Col1a1-cre/Esr1*)1Mis/0
  http://metadb.riken.jp/0001533I129S7SvEvBrdBmpr1atm21BhrBmpr1atm21BhrTgCol1a1creEsr11Mis0Bmpr1atm21BhrTgCol1a1creEsr11Mis