Jaan-Olle. Andressoo, et.al., An Xpb mouse model for combined xeroderma pigmentosum and cockayne syndrome reveals progeroid features upon further attenuation of DNA repair., Molecular and cellular biology, 2009, 29

http://rdf.ncbi.nlm.nih.gov/pubmed/19114557

Jaan-Olle. Andressoo, et.al., An Xpb mouse model for combined xeroderma pigmentosum and cockayne syndrome reveals progeroid features upon further attenuation of DNA repair., Molecular and cellular biology, 2009, 29

http://rdf.ncbi.nlm.nih.gov/pubmed/

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD39319
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD39319
• CD48386
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD48386

allele

http://purl.org/net/cito/citesAsAuthority

• Ercc3<tm1Jhjh>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3836421
• Ercc3<tm2Jhjh>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3836429

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• kyphosis_Ercc3<tm2Jhjh>/Ercc3<tm2Jhjh>,Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0000160I129P2OlaHsdC57BL6Ercc3tm2JhjhErcc3tm2JhjhXpatm1HvsXpatm1HvsXpatm1HvsErcc3tm2Jhjh
• increased cellular sensitivity to ultraviolet irradiation_Ercc3<tm2Jhjh>/Ercc3<tm2Jhjh>,Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0008410I129P2OlaHsdC57BL6Ercc3tm2JhjhErcc3tm2JhjhXpatm1HvsXpatm1HvsXpatm1HvsErcc3tm2Jhjh
• cachexia_Ercc3<tm2Jhjh>/Ercc3<tm2Jhjh>,Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0005150I129P2OlaHsdC57BL6Ercc3tm2JhjhErcc3tm2JhjhXpatm1HvsXpatm1HvsXpatm1HvsErcc3tm2Jhjh
• decreased body weight_Ercc3<tm2Jhjh>/Ercc3<tm2Jhjh>,Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0001262I129P2OlaHsdC57BL6Ercc3tm2JhjhErcc3tm2JhjhXpatm1HvsXpatm1HvsXpatm1HvsErcc3tm2Jhjh
• increased cellular sensitivity to gamma-irradiation_Ercc3<tm2Jhjh>/Ercc3<tm2Jhjh>
  http://metadb.riken.jp/0002007B6129P2Ercc3tm2JhjhErcc3tm2JhjhErcc3tm2JhjhErcc3tm2Jhjh
• reddish skin_Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0001190I129P2OlaHsdXpatm1HvsXpatm1HvsXpatm1Hvs
• muscle hypertonia_Ercc3<tm2Jhjh>/Ercc3<tm2Jhjh>,Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0004143I129P2OlaHsdC57BL6Ercc3tm2JhjhErcc3tm2JhjhXpatm1HvsXpatm1HvsXpatm1HvsErcc3tm2Jhjh
• increased cellular sensitivity to oxidative stress_Ercc3<tm2Jhjh>/Ercc3<tm2Jhjh>,Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0008412I129P2OlaHsdC57BL6Ercc3tm2JhjhErcc3tm2JhjhXpatm1HvsXpatm1HvsXpatm1HvsErcc3tm2Jhjh
• embryonic lethality between somite formation and embryo turning, complete penetrance_Ercc3<tm1Jhjh>/Ercc3<tm1Jhjh>
  http://metadb.riken.jp/0011097B6129P2Ercc3tm1JhjhErcc3tm1JhjhErcc3tm1JhjhErcc3tm1Jhjh
• increased cellular sensitivity to ultraviolet irradiation_Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0008410I129P2OlaHsdXpatm1HvsXpatm1HvsXpatm1Hvs
• impaired limb coordination_Ercc3<tm2Jhjh>/Ercc3<tm2Jhjh>,Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0001524I129P2OlaHsdC57BL6Ercc3tm2JhjhErcc3tm2JhjhXpatm1HvsXpatm1HvsXpatm1HvsErcc3tm2Jhjh
• postnatal lethality, complete penetrance_Ercc2<tm2(ERCC2)Jhjh>/Ercc2<tm2(ERCC2)Jhjh>,Ercc3<tm2Jhjh>/Ercc3<tm2Jhjh>
  http://metadb.riken.jp/0011085I129P2OlaHsdC57BL6Ercc2tm2ERCC2JhjhErcc2tm2ERCC2JhjhErcc3tm2JhjhErcc3tm2JhjhErcc3tm2JhjhErcc2tm2ERCC2Jhjh
• increased cellular sensitivity to gamma-irradiation_Ercc3<tm2Jhjh>/Ercc3<tm2Jhjh>,Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0002007I129P2OlaHsdC57BL6Ercc3tm2JhjhErcc3tm2JhjhXpatm1HvsXpatm1HvsXpatm1HvsErcc3tm2Jhjh
• abnormal epidermal layer morphology_Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0001216I129P2OlaHsdXpatm1HvsXpatm1HvsXpatm1Hvs
• slow postnatal weight gain_Ercc3<tm2Jhjh>/Ercc3<tm2Jhjh>,Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0008489I129P2OlaHsdC57BL6Ercc3tm2JhjhErcc3tm2JhjhXpatm1HvsXpatm1HvsXpatm1HvsErcc3tm2Jhjh
• premature death_Ercc3<tm2Jhjh>/Ercc3<tm2Jhjh>,Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0002083I129P2OlaHsdC57BL6Ercc3tm2JhjhErcc3tm2JhjhXpatm1HvsXpatm1HvsXpatm1HvsErcc3tm2Jhjh
• abnormal cranium morphology_Ercc3<tm2Jhjh>/Ercc3<tm2Jhjh>,Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0000438I129P2OlaHsdC57BL6Ercc3tm2JhjhErcc3tm2JhjhXpatm1HvsXpatm1HvsXpatm1HvsErcc3tm2Jhjh
• increased cellular sensitivity to ultraviolet irradiation_Ercc2<tm2(ERCC2)Jhjh>/Ercc2<tm2(ERCC2)Jhjh>,Ercc3<tm2Jhjh>/Ercc3<tm2Jhjh>
  http://metadb.riken.jp/0008410I129P2OlaHsdC57BL6Ercc2tm2ERCC2JhjhErcc2tm2ERCC2JhjhErcc3tm2JhjhErcc3tm2JhjhErcc3tm2JhjhErcc2tm2ERCC2Jhjh
• tremors_Ercc3<tm2Jhjh>/Ercc3<tm2Jhjh>,Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0000745I129P2OlaHsdC57BL6Ercc3tm2JhjhErcc3tm2JhjhXpatm1HvsXpatm1HvsXpatm1HvsErcc3tm2Jhjh
• epidermal hyperplasia_Ercc3<tm2Jhjh>/Ercc3<tm2Jhjh>
  http://metadb.riken.jp/0001222B6129P2Ercc3tm2JhjhErcc3tm2JhjhErcc3tm2JhjhErcc3tm2Jhjh
• acanthosis_Ercc3<tm2Jhjh>/Ercc3<tm2Jhjh>
  http://metadb.riken.jp/0001874B6129P2Ercc3tm2JhjhErcc3tm2JhjhErcc3tm2JhjhErcc3tm2Jhjh
• premature aging_Ercc3<tm2Jhjh>/Ercc3<tm2Jhjh>,Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0003786I129P2OlaHsdC57BL6Ercc3tm2JhjhErcc3tm2JhjhXpatm1HvsXpatm1HvsXpatm1HvsErcc3tm2Jhjh
• increased cellular sensitivity to oxidative stress_Ercc2<tm2(ERCC2)Jhjh>/Ercc2<tm2(ERCC2)Jhjh>,Ercc3<tm2Jhjh>/Ercc3<tm2Jhjh>
  http://metadb.riken.jp/0008412I129P2OlaHsdC57BL6Ercc2tm2ERCC2JhjhErcc2tm2ERCC2JhjhErcc3tm2JhjhErcc3tm2JhjhErcc3tm2JhjhErcc2tm2ERCC2Jhjh
• scaly skin_Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0001192I129P2OlaHsdXpatm1HvsXpatm1HvsXpatm1Hvs
• increased cellular sensitivity to gamma-irradiation_Ercc2<tm2(ERCC2)Jhjh>/Ercc2<tm2(ERCC2)Jhjh>,Ercc3<tm2Jhjh>/Ercc3<tm2Jhjh>
  http://metadb.riken.jp/0002007I129P2OlaHsdC57BL6Ercc2tm2ERCC2JhjhErcc2tm2ERCC2JhjhErcc3tm2JhjhErcc3tm2JhjhErcc3tm2JhjhErcc2tm2ERCC2Jhjh
• increased cellular sensitivity to ultraviolet irradiation_Ercc3<tm2Jhjh>/Ercc3<tm2Jhjh>
  http://metadb.riken.jp/0008410B6129P2Ercc3tm2JhjhErcc3tm2JhjhErcc3tm2JhjhErcc3tm2Jhjh
• skin edema_Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0001786I129P2OlaHsdXpatm1HvsXpatm1HvsXpatm1Hvs
• acanthosis_Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0001874I129P2OlaHsdXpatm1HvsXpatm1HvsXpatm1Hvs
• hyperactivity_Ercc3<tm2Jhjh>/Ercc3<tm2Jhjh>,Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0001399I129P2OlaHsdC57BL6Ercc3tm2JhjhErcc3tm2JhjhXpatm1HvsXpatm1HvsXpatm1HvsErcc3tm2Jhjh
• impaired balance_Ercc3<tm2Jhjh>/Ercc3<tm2Jhjh>,Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0001525I129P2OlaHsdC57BL6Ercc3tm2JhjhErcc3tm2JhjhXpatm1HvsXpatm1HvsXpatm1HvsErcc3tm2Jhjh
• increased cellular sensitivity to ultraviolet irradiation_Ercc2<tm2(ERCC2)Jhjh>/Ercc2<tm2(ERCC2)Jhjh>
  http://metadb.riken.jp/0008410I129P2OlaHsdErcc2tm2ERCC2JhjhErcc2tm2ERCC2JhjhErcc2tm2ERCC2Jhjh
• abnormal gait_Ercc3<tm2Jhjh>/Ercc3<tm2Jhjh>,Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0001406I129P2OlaHsdC57BL6Ercc3tm2JhjhErcc3tm2JhjhXpatm1HvsXpatm1HvsXpatm1HvsErcc3tm2Jhjh
• testicular atrophy_Ercc3<tm2Jhjh>/Ercc3<tm2Jhjh>,Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0003205I129P2OlaHsdC57BL6Ercc3tm2JhjhErcc3tm2JhjhXpatm1HvsXpatm1HvsXpatm1HvsErcc3tm2Jhjh
• ataxia_Ercc3<tm2Jhjh>/Ercc3<tm2Jhjh>,Xpa<tm1Hvs>/Xpa<tm1Hvs>
  http://metadb.riken.jp/0001393I129P2OlaHsdC57BL6Ercc3tm2JhjhErcc3tm2JhjhXpatm1HvsXpatm1HvsXpatm1HvsErcc3tm2Jhjh
• postnatal growth retardation_Ercc2<tm2(ERCC2)Jhjh>/Ercc2<tm2(ERCC2)Jhjh>,Ercc3<tm2Jhjh>/Ercc3<tm2Jhjh>
  http://metadb.riken.jp/0001732I129P2OlaHsdC57BL6Ercc2tm2ERCC2JhjhErcc2tm2ERCC2JhjhErcc3tm2JhjhErcc3tm2JhjhErcc3tm2JhjhErcc2tm2ERCC2Jhjh