Emilie A. Leclerc, et.al., Corneodesmosin gene ablation induces lethal skin-barrier disruption and hair-follicle degeneration related to desmosome dysfunction., Journal of cell science, 2009, 122

http://rdf.ncbi.nlm.nih.gov/pubmed/19596793

Emilie A. Leclerc, et.al., Corneodesmosin gene ablation induces lethal skin-barrier disruption and hair-follicle degeneration related to desmosome dysfunction., Journal of cell science, 2009, 122

http://rdf.ncbi.nlm.nih.gov/pubmed/

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD11486
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD11486

allele

http://purl.org/net/cito/citesAsAuthority

• Cdsn<tm1.1Ics>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4365388

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• weight loss_Cdsn<tm1.1Ics>/Cdsn<tm1.1Ics>,Tg(KRT14-cre/ERT2)1Ipc/0
  http://metadb.riken.jp/0001263I129S2SvPasCdsntm11IcsCdsntm11IcsTgKRT14creERT21Ipc0TgKRT14creERT21IpcCdsntm11Ics
• impaired skin barrier function_Cdsn<tm1.1Ics>/Cdsn<tm1.1Ics>,Tg(KRT14-cre/ERT2)1Ipc/0
  http://metadb.riken.jp/0002796I129S2SvPasCdsntm11IcsCdsntm11IcsTgKRT14creERT21Ipc0TgKRT14creERT21IpcCdsntm11Ics
• spontaneous skin ulceration_Cdsn<tm1.1Ics>/Cdsn<tm1.1Ics>,Tg(KRT14-cre/ERT2)1Ipc/0
  http://metadb.riken.jp/0001209I129S2SvPasCdsntm11IcsCdsntm11IcsTgKRT14creERT21Ipc0TgKRT14creERT21IpcCdsntm11Ics
• decreased skin tensile strength_Cdsn<tm1.1Ics>/Cdsn<tm1.1Ics>,Tg(KRT14-cre)1Ipc/0
  http://metadb.riken.jp/0003089I129S2SvPasC57BL6SJLCdsntm11IcsCdsntm11IcsTgKRT14cre1Ipc0TgKRT14cre1IpcCdsntm11Ics
• scaly skin_Cdsn<tm1.1Ics>/Cdsn<tm1.1Ics>,Tg(KRT14-cre/ERT2)1Ipc/0
  http://metadb.riken.jp/0001192I129S2SvPasCdsntm11IcsCdsntm11IcsTgKRT14creERT21Ipc0TgKRT14creERT21IpcCdsntm11Ics
• hair follicle degeneration_Cdsn<tm1.1Ics>/Cdsn<tm1.1Ics>,Tg(KRT14-cre/ERT2)1Ipc/0
  http://metadb.riken.jp/0003413I129S2SvPasCdsntm11IcsCdsntm11IcsTgKRT14creERT21Ipc0TgKRT14creERT21IpcCdsntm11Ics
• parakeratosis_Cdsn<tm1.1Ics>/Cdsn<tm1.1Ics>,Tg(KRT14-cre)1Ipc/0
  http://metadb.riken.jp/0003427I129S2SvPasC57BL6SJLCdsntm11IcsCdsntm11IcsTgKRT14cre1Ipc0TgKRT14cre1IpcCdsntm11Ics
• premature death_Cdsn<tm1.1Ics>/Cdsn<tm1.1Ics>,Tg(KRT14-cre/ERT2)1Ipc/0
  http://metadb.riken.jp/0002083I129S2SvPasCdsntm11IcsCdsntm11IcsTgKRT14creERT21Ipc0TgKRT14creERT21IpcCdsntm11Ics
• impaired skin barrier function_Cdsn<tm1.1Ics>/Cdsn<tm1.1Ics>,Tg(KRT14-cre)1Ipc/0
  http://metadb.riken.jp/0002796I129S2SvPasC57BL6SJLCdsntm11IcsCdsntm11IcsTgKRT14cre1Ipc0TgKRT14cre1IpcCdsntm11Ics
• neonatal lethality, complete penetrance_Cdsn<tm1.1Ics>/Cdsn<tm1.1Ics>,Tg(KRT14-cre)1Ipc/0
  http://metadb.riken.jp/0011087I129S2SvPasC57BL6SJLCdsntm11IcsCdsntm11IcsTgKRT14cre1Ipc0TgKRT14cre1IpcCdsntm11Ics
• spontaneous skin ulceration_Cdsn<tm1.1Ics>/Cdsn<tm1.1Ics>,Tg(KRT14-cre)1Ipc/0
  http://metadb.riken.jp/0001209I129S2SvPasC57BL6SJLCdsntm11IcsCdsntm11IcsTgKRT14cre1Ipc0TgKRT14cre1IpcCdsntm11Ics
• abnormal epidermal layer morphology_Cdsn<tm1.1Ics>/Cdsn<tm1.1Ics>,Tg(KRT14-cre)1Ipc/0
  http://metadb.riken.jp/0001216I129S2SvPasC57BL6SJLCdsntm11IcsCdsntm11IcsTgKRT14cre1Ipc0TgKRT14cre1IpcCdsntm11Ics
• dermal cysts_Cdsn<tm1.1Ics>/Cdsn<tm1.1Ics>,Tg(KRT14-cre)1Ipc/0
  http://metadb.riken.jp/0001247I129S2SvPasC57BL6SJLCdsntm11IcsCdsntm11IcsTgKRT14cre1Ipc0TgKRT14cre1IpcCdsntm11Ics
• skin inflammation_Cdsn<tm1.1Ics>/Cdsn<tm1.1Ics>,Tg(KRT14-cre/ERT2)1Ipc/0
  http://metadb.riken.jp/0004947I129S2SvPasCdsntm11IcsCdsntm11IcsTgKRT14creERT21Ipc0TgKRT14creERT21IpcCdsntm11Ics
• increased skin papilloma incidence_Cdsn<tm1.1Ics>/Cdsn<tm1.1Ics>,Tg(KRT14-cre)1Ipc/0
  http://metadb.riken.jp/0002051I129S2SvPasC57BL6SJLCdsntm11IcsCdsntm11IcsTgKRT14cre1Ipc0TgKRT14cre1IpcCdsntm11Ics
• mixed cellular infiltration to dermis_Cdsn<tm1.1Ics>/Cdsn<tm1.1Ics>,Tg(KRT14-cre)1Ipc/0
  http://metadb.riken.jp/0001246I129S2SvPasC57BL6SJLCdsntm11IcsCdsntm11IcsTgKRT14cre1Ipc0TgKRT14cre1IpcCdsntm11Ics
• epidermal hyperplasia_Cdsn<tm1.1Ics>/Cdsn<tm1.1Ics>,Tg(KRT14-cre)1Ipc/0
  http://metadb.riken.jp/0001222I129S2SvPasC57BL6SJLCdsntm11IcsCdsntm11IcsTgKRT14cre1Ipc0TgKRT14cre1IpcCdsntm11Ics
• absent epidermis stratum corneum_Cdsn<tm1.1Ics>/Cdsn<tm1.1Ics>,Tg(KRT14-cre)1Ipc/0
  http://metadb.riken.jp/0001241I129S2SvPasC57BL6SJLCdsntm11IcsCdsntm11IcsTgKRT14cre1Ipc0TgKRT14cre1IpcCdsntm11Ics
• sebaceous gland hypertrophy_Cdsn<tm1.1Ics>/Cdsn<tm1.1Ics>,Tg(KRT14-cre/ERT2)1Ipc/0
  http://metadb.riken.jp/0009793I129S2SvPasCdsntm11IcsCdsntm11IcsTgKRT14creERT21Ipc0TgKRT14creERT21IpcCdsntm11Ics
• hairless_Cdsn<tm1.1Ics>/Cdsn<tm1.1Ics>,Tg(KRT14-cre)1Ipc/0
  http://metadb.riken.jp/0003815I129S2SvPasC57BL6SJLCdsntm11IcsCdsntm11IcsTgKRT14cre1Ipc0TgKRT14cre1IpcCdsntm11Ics
• hyperkeratosis_Cdsn<tm1.1Ics>/Cdsn<tm1.1Ics>,Tg(KRT14-cre/ERT2)1Ipc/0
  http://metadb.riken.jp/0001242I129S2SvPasCdsntm11IcsCdsntm11IcsTgKRT14creERT21Ipc0TgKRT14creERT21IpcCdsntm11Ics
• acanthosis_Cdsn<tm1.1Ics>/Cdsn<tm1.1Ics>,Tg(KRT14-cre/ERT2)1Ipc/0
  http://metadb.riken.jp/0001874I129S2SvPasCdsntm11IcsCdsntm11IcsTgKRT14creERT21Ipc0TgKRT14creERT21IpcCdsntm11Ics
• distended hair follicles_Cdsn<tm1.1Ics>/Cdsn<tm1.1Ics>,Tg(KRT14-cre/ERT2)1Ipc/0
  http://metadb.riken.jp/0000385I129S2SvPasCdsntm11IcsCdsntm11IcsTgKRT14creERT21Ipc0TgKRT14creERT21IpcCdsntm11Ics
• abnormal skin condition_Cdsn<tm1.1Ics>/Cdsn<tm1.1Ics>,Tg(KRT14-cre)1Ipc/0
  http://metadb.riken.jp/0001191I129S2SvPasC57BL6SJLCdsntm11IcsCdsntm11IcsTgKRT14cre1Ipc0TgKRT14cre1IpcCdsntm11Ics
• hyperkeratosis_Cdsn<tm1.1Ics>/Cdsn<tm1.1Ics>,Tg(KRT14-cre)1Ipc/0
  http://metadb.riken.jp/0001242I129S2SvPasC57BL6SJLCdsntm11IcsCdsntm11IcsTgKRT14cre1Ipc0TgKRT14cre1IpcCdsntm11Ics
• parakeratosis_Cdsn<tm1.1Ics>/Cdsn<tm1.1Ics>,Tg(KRT14-cre/ERT2)1Ipc/0
  http://metadb.riken.jp/0003427I129S2SvPasCdsntm11IcsCdsntm11IcsTgKRT14creERT21Ipc0TgKRT14creERT21IpcCdsntm11Ics