Katherine I. Oravecz-Wilson, et.al., Persistence of leukemia-initiating cells in a conditional knockin model of an imatinib-responsive myeloproliferative disorder., Cancer cell, 2009, 16

http://rdf.ncbi.nlm.nih.gov/pubmed/19647224

Katherine I. Oravecz-Wilson, et.al., Persistence of leukemia-initiating cells in a conditional knockin model of an imatinib-responsive myeloproliferative disorder., Cancer cell, 2009, 16

http://rdf.ncbi.nlm.nih.gov/pubmed/

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD09218
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD09218

allele

http://purl.org/net/cito/citesAsAuthority

• Hip1<tm4Tsr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4356264

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased hematopoietic stem cell number_Hip1<tm4Tsr>/Hip1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0004810I129X1SvJC57BL6CBAHip1tm4TsrHip1TgMx1cre1Cgn0Hip1TgMx1cre1CgnHip1tm4Tsr
• decreased bone marrow cell number_Hip1<tm4Tsr>/Hip1<+>,Runx1<tm3Dow>/Runx1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000333I129X1SvJC57BL6CBAHip1tm4TsrHip1Runx1tm3DowRunx1TgMx1cre1Cgn0Hip1TgMx1cre1CgnRunx1Runx1tm3DowHip1tm4Tsr
• microphthalmia_Hip1<tm4Tsr>/Hip1<+>
  http://metadb.riken.jp/0001297I129X1SvJC57BL6Hip1tm4TsrHip1Hip1tm4TsrHip1
• increased spleen weight_Hip1<tm4Tsr>/Hip1<+>,Runx1<tm3Dow>/Runx1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0004952I129X1SvJC57BL6CBAHip1tm4TsrHip1Runx1tm3DowRunx1TgMx1cre1Cgn0Hip1TgMx1cre1CgnRunx1Runx1tm3DowHip1tm4Tsr
• increased liver weight_Hip1<tm4Tsr>/Hip1<+>,Runx1<tm3Dow>/Runx1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002981I129X1SvJC57BL6CBAHip1tm4TsrHip1Runx1tm3DowRunx1TgMx1cre1Cgn0Hip1TgMx1cre1CgnRunx1Runx1tm3DowHip1tm4Tsr
• increased leukocyte cell number_Hip1<tm4Tsr>/Hip1<+>,Runx1<tm3Dow>/Runx1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000218I129X1SvJC57BL6CBAHip1tm4TsrHip1Runx1tm3DowRunx1TgMx1cre1Cgn0Hip1TgMx1cre1CgnRunx1Runx1tm3DowHip1tm4Tsr
• abnormal spleen B cell follicle morphology_Hip1<tm4Tsr>/Hip1<+>,Runx1<tm3Dow>/Runx1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008470I129X1SvJC57BL6CBAHip1tm4TsrHip1Runx1tm3DowRunx1TgMx1cre1Cgn0Hip1TgMx1cre1CgnRunx1Runx1tm3DowHip1tm4Tsr
• extramedullary hematopoiesis_Hip1<tm4Tsr>/Hip1<+>,Runx1<tm3Dow>/Runx1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000240I129X1SvJC57BL6CBAHip1tm4TsrHip1Runx1tm3DowRunx1TgMx1cre1Cgn0Hip1TgMx1cre1CgnRunx1Runx1tm3DowHip1tm4Tsr
• postnatal lethality_Hip1<tm4Tsr>/Hip1<+>,Runx1<tm3Dow>/Runx1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002082I129X1SvJC57BL6CBAHip1tm4TsrHip1Runx1tm3DowRunx1TgMx1cre1Cgn0Hip1TgMx1cre1CgnRunx1Runx1tm3DowHip1tm4Tsr
• decreased common myeloid progenitor cell number_Hip1<tm4Tsr>/Hip1<+>,Runx1<tm3Dow>/Runx1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008813I129X1SvJC57BL6CBAHip1tm4TsrHip1Runx1tm3DowRunx1TgMx1cre1Cgn0Hip1TgMx1cre1CgnRunx1Runx1tm3DowHip1tm4Tsr
• enlarged liver_Hip1<tm4Tsr>/Hip1<+>,Runx1<tm3Dow>/Runx1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000599I129X1SvJC57BL6CBAHip1tm4TsrHip1Runx1tm3DowRunx1TgMx1cre1Cgn0Hip1TgMx1cre1CgnRunx1Runx1tm3DowHip1tm4Tsr
• abnormal liver parenchyma morphology_Hip1<tm4Tsr>/Hip1<+>,Runx1<tm3Dow>/Runx1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008986I129X1SvJC57BL6CBAHip1tm4TsrHip1Runx1tm3DowRunx1TgMx1cre1Cgn0Hip1TgMx1cre1CgnRunx1Runx1tm3DowHip1tm4Tsr
• abnormal liver morphology_Hip1<tm4Tsr>/Hip1<+>,Runx1<tm3Dow>/Runx1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000598I129X1SvJC57BL6CBAHip1tm4TsrHip1Runx1tm3DowRunx1TgMx1cre1Cgn0Hip1TgMx1cre1CgnRunx1Runx1tm3DowHip1tm4Tsr
• cataract_Hip1<tm4Tsr>/Hip1<+>
  http://metadb.riken.jp/0001304I129X1SvJC57BL6Hip1tm4TsrHip1Hip1tm4TsrHip1
• increased hematopoietic stem cell number_Hip1<tm4Tsr>/Hip1<+>,Runx1<tm3Dow>/Runx1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0004809I129X1SvJC57BL6CBAHip1tm4TsrHip1Runx1tm3DowRunx1TgMx1cre1Cgn0Hip1TgMx1cre1CgnRunx1Runx1tm3DowHip1tm4Tsr
• increased hepatocellular carcinoma incidence_Hip1<tm4Tsr>/Hip1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0003331I129X1SvJC57BL6CBAHip1tm4TsrHip1TgMx1cre1Cgn0Hip1TgMx1cre1CgnHip1tm4Tsr
• enlarged spleen_Hip1<tm4Tsr>/Hip1<+>,Runx1<tm3Dow>/Runx1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000691I129X1SvJC57BL6CBAHip1tm4TsrHip1Runx1tm3DowRunx1TgMx1cre1Cgn0Hip1TgMx1cre1CgnRunx1Runx1tm3DowHip1tm4Tsr
• abnormal tumor morphology_Hip1<tm4Tsr>/Hip1<+>,Runx1<tm3Dow>/Runx1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0003448I129X1SvJC57BL6CBAHip1tm4TsrHip1Runx1tm3DowRunx1TgMx1cre1Cgn0Hip1TgMx1cre1CgnRunx1Runx1tm3DowHip1tm4Tsr
• abnormal myelopoiesis_Hip1<tm4Tsr>/Hip1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0001601I129X1SvJC57BL6CBAHip1tm4TsrHip1TgMx1cre1Cgn0Hip1TgMx1cre1CgnHip1tm4Tsr
• enlarged spleen_Hip1<tm4Tsr>/Hip1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000691I129X1SvJC57BL6CBAHip1tm4TsrHip1TgMx1cre1Cgn0Hip1TgMx1cre1CgnHip1tm4Tsr
• abnormal myelopoiesis_Hip1<tm4Tsr>/Hip1<+>,Runx1<tm3Dow>/Runx1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0001601I129X1SvJC57BL6CBAHip1tm4TsrHip1Runx1tm3DowRunx1TgMx1cre1Cgn0Hip1TgMx1cre1CgnRunx1Runx1tm3DowHip1tm4Tsr
• increased sensitivity to xenobiotic induced morbidity/mortality_Hip1<tm4Tsr>/Hip1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0009766I129X1SvJC57BL6CBAHip1tm4TsrHip1TgMx1cre1Cgn0Hip1TgMx1cre1CgnHip1tm4Tsr
• abnormal spleen morphology_Hip1<tm4Tsr>/Hip1<+>,Runx1<tm3Dow>/Runx1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000689I129X1SvJC57BL6CBAHip1tm4TsrHip1Runx1tm3DowRunx1TgMx1cre1Cgn0Hip1TgMx1cre1CgnRunx1Runx1tm3DowHip1tm4Tsr
• abnormal spleen morphology_Hip1<tm4Tsr>/Hip1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000689I129X1SvJC57BL6CBAHip1tm4TsrHip1TgMx1cre1Cgn0Hip1TgMx1cre1CgnHip1tm4Tsr
• increased chronic myelocytic leukemia incidence_Hip1<tm4Tsr>/Hip1<+>,Runx1<tm3Dow>/Runx1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005481I129X1SvJC57BL6CBAHip1tm4TsrHip1Runx1tm3DowRunx1TgMx1cre1Cgn0Hip1TgMx1cre1CgnRunx1Runx1tm3DowHip1tm4Tsr
• increased neutrophil cell number_Hip1<tm4Tsr>/Hip1<+>,Runx1<tm3Dow>/Runx1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000219I129X1SvJC57BL6CBAHip1tm4TsrHip1Runx1tm3DowRunx1TgMx1cre1Cgn0Hip1TgMx1cre1CgnRunx1Runx1tm3DowHip1tm4Tsr
• increased T cell derived lymphoma incidence_Hip1<tm4Tsr>/Hip1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002024I129X1SvJC57BL6CBAHip1tm4TsrHip1TgMx1cre1Cgn0Hip1TgMx1cre1CgnHip1tm4Tsr
• abnormal bone marrow cell physiology_Hip1<tm4Tsr>/Hip1<+>,Runx1<tm3Dow>/Runx1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0009278I129X1SvJC57BL6CBAHip1tm4TsrHip1Runx1tm3DowRunx1TgMx1cre1Cgn0Hip1TgMx1cre1CgnRunx1Runx1tm3DowHip1tm4Tsr
• increased spleen red pulp amount_Hip1<tm4Tsr>/Hip1<+>,Runx1<tm3Dow>/Runx1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008476I129X1SvJC57BL6CBAHip1tm4TsrHip1Runx1tm3DowRunx1TgMx1cre1Cgn0Hip1TgMx1cre1CgnRunx1Runx1tm3DowHip1tm4Tsr
• abnormal lung morphology_Hip1<tm4Tsr>/Hip1<+>,Runx1<tm3Dow>/Runx1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0001175I129X1SvJC57BL6CBAHip1tm4TsrHip1Runx1tm3DowRunx1TgMx1cre1Cgn0Hip1TgMx1cre1CgnRunx1Runx1tm3DowHip1tm4Tsr
• spleen hyperplasia_Hip1<tm4Tsr>/Hip1<+>,Runx1<tm3Dow>/Runx1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000693I129X1SvJC57BL6CBAHip1tm4TsrHip1Runx1tm3DowRunx1TgMx1cre1Cgn0Hip1TgMx1cre1CgnRunx1Runx1tm3DowHip1tm4Tsr
• abnormal bone marrow cell morphology/development_Hip1<tm4Tsr>/Hip1<+>,Runx1<tm3Dow>/Runx1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002398I129X1SvJC57BL6CBAHip1tm4TsrHip1Runx1tm3DowRunx1TgMx1cre1Cgn0Hip1TgMx1cre1CgnRunx1Runx1tm3DowHip1tm4Tsr
• increased liver tumor incidence_Hip1<tm4Tsr>/Hip1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008019I129X1SvJC57BL6CBAHip1tm4TsrHip1TgMx1cre1Cgn0Hip1TgMx1cre1CgnHip1tm4Tsr
• increased granulocyte number_Hip1<tm4Tsr>/Hip1<+>,Runx1<tm3Dow>/Runx1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000322I129X1SvJC57BL6CBAHip1tm4TsrHip1Runx1tm3DowRunx1TgMx1cre1Cgn0Hip1TgMx1cre1CgnRunx1Runx1tm3DowHip1tm4Tsr
• increased spleen red pulp amount_Hip1<tm4Tsr>/Hip1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008476I129X1SvJC57BL6CBAHip1tm4TsrHip1TgMx1cre1Cgn0Hip1TgMx1cre1CgnHip1tm4Tsr
• abnormal definitive hematopoiesis_Hip1<tm4Tsr>/Hip1<+>,Runx1<tm3Dow>/Runx1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002123I129X1SvJC57BL6CBAHip1tm4TsrHip1Runx1tm3DowRunx1TgMx1cre1Cgn0Hip1TgMx1cre1CgnRunx1Runx1tm3DowHip1tm4Tsr
• decreased hematopoietic stem cell number_Hip1<tm4Tsr>/Hip1<+>,Runx1<tm3Dow>/Runx1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0004810I129X1SvJC57BL6CBAHip1tm4TsrHip1Runx1tm3DowRunx1TgMx1cre1Cgn0Hip1TgMx1cre1CgnRunx1Runx1tm3DowHip1tm4Tsr
• abnormal tumor incidence_Hip1<tm4Tsr>/Hip1<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002019I129X1SvJC57BL6CBAHip1tm4TsrHip1TgMx1cre1Cgn0Hip1TgMx1cre1CgnHip1tm4Tsr