David J. Lloyd, et.al., A point mutation in Sec61alpha1 leads to diabetes and hepatosteatosis in mice., Diabetes, 2010, 59

http://rdf.ncbi.nlm.nih.gov/pubmed/19934005

David J. Lloyd, et.al., A point mutation in Sec61alpha1 leads to diabetes and hepatosteatosis in mice., Diabetes, 2010, 59

http://rdf.ncbi.nlm.nih.gov/pubmed/

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD02551
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD02551

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(Ins2-Sec61a1)#Gek
  http://metadb.riken.jp/db/mgi_rdf/MGI:4831008
• Sec61a1<m1Gek>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4830998

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased total body fat amount_Sec61a1<m1Gek>/Sec61a1<m1Gek>,Tg(Ins2-Sec61a1)#Gek/0
  http://metadb.riken.jp/0010025C57BL6Sec61a1m1GekTgIns2Sec61a1GekSec61a1m1GekSec61a1m1GekTgIns2Sec61a1Gek0TgIns2Sec61a1GekSec61a1m1Gek
• decreased circulating insulin level_Sec61a1<m1Gek>/Sec61a1<+>
  http://metadb.riken.jp/0002727C57BL6JSec61a1m1GekSec61a1m1GekSec61a1Sec61a1m1GekSec61a1
• liver cirrhosis_Sec61a1<m1Gek>/Sec61a1<m1Gek>,Tg(Ins2-Sec61a1)#Gek/0
  http://metadb.riken.jp/0003046C57BL6Sec61a1m1GekTgIns2Sec61a1GekSec61a1m1GekSec61a1m1GekTgIns2Sec61a1Gek0TgIns2Sec61a1GekSec61a1m1Gek
• decreased body size_Sec61a1<m1Gek>/Sec61a1<m1Gek>,Tg(Ins2-Sec61a1)#Gek/0
  http://metadb.riken.jp/0001265C57BL6Sec61a1m1GekTgIns2Sec61a1GekSec61a1m1GekSec61a1m1GekTgIns2Sec61a1Gek0TgIns2Sec61a1GekSec61a1m1Gek
• decreased total body fat amount_Sec61a1<m1Gek>/Sec61a1<m1Gek>
  http://metadb.riken.jp/0010025C57BL6JSec61a1m1GekSec61a1m1GekSec61a1m1GekSec61a1m1Gek
• increased hepatocyte apoptosis_Sec61a1<m1Gek>/Sec61a1<m1Gek>
  http://metadb.riken.jp/0003887C57BL6JSec61a1m1GekSec61a1m1GekSec61a1m1GekSec61a1m1Gek
• pale liver_Sec61a1<m1Gek>/Sec61a1<m1Gek>
  http://metadb.riken.jp/0000603C57BL6JSec61a1m1GekSec61a1m1GekSec61a1m1GekSec61a1m1Gek
• increased circulating triglyceride level_Sec61a1<m1Gek>/Sec61a1<m1Gek>
  http://metadb.riken.jp/0001552C57BL6JSec61a1m1GekSec61a1m1GekSec61a1m1GekSec61a1m1Gek
• increased pancreatic delta cell number_Sec61a1<m1Gek>/Sec61a1<m1Gek>
  http://metadb.riken.jp/0009180C57BL6JSec61a1m1GekSec61a1m1GekSec61a1m1GekSec61a1m1Gek
• decreased skeletal muscle mass_Sec61a1<m1Gek>/Sec61a1<m1Gek>
  http://metadb.riken.jp/0004819C57BL6JSec61a1m1GekSec61a1m1GekSec61a1m1GekSec61a1m1Gek
• hyperglycemia_Sec61a1<m1Gek>/Sec61a1<m1Gek>
  http://metadb.riken.jp/0001559C57BL6JSec61a1m1GekSec61a1m1GekSec61a1m1GekSec61a1m1Gek
• liver cirrhosis_Sec61a1<m1Gek>/Sec61a1<m1Gek>
  http://metadb.riken.jp/0003046C57BL6JSec61a1m1GekSec61a1m1GekSec61a1m1GekSec61a1m1Gek
• hepatic steatosis_Sec61a1<m1Gek>/Sec61a1<m1Gek>,Tg(Ins2-Sec61a1)#Gek/0
  http://metadb.riken.jp/0002628C57BL6Sec61a1m1GekTgIns2Sec61a1GekSec61a1m1GekSec61a1m1GekTgIns2Sec61a1Gek0TgIns2Sec61a1GekSec61a1m1Gek
• abnormal pancreatic beta cell morphology_Sec61a1<m1Gek>/Sec61a1<m1Gek>,Tg(Ins2-Sec61a1)#Gek/0
  http://metadb.riken.jp/0005217C57BL6Sec61a1m1GekTgIns2Sec61a1GekSec61a1m1GekSec61a1m1GekTgIns2Sec61a1Gek0TgIns2Sec61a1GekSec61a1m1Gek
• decreased lean body mass_Sec61a1<m1Gek>/Sec61a1<m1Gek>
  http://metadb.riken.jp/0003961C57BL6JSec61a1m1GekSec61a1m1GekSec61a1m1GekSec61a1m1Gek
• abnormal pancreatic beta cell morphology_Sec61a1<m1Gek>/Sec61a1<m1Gek>
  http://metadb.riken.jp/0005217C57BL6JSec61a1m1GekSec61a1m1GekSec61a1m1GekSec61a1m1Gek
• increased circulating glucagon level_Sec61a1<m1Gek>/Sec61a1<m1Gek>
  http://metadb.riken.jp/0002712C57BL6JSec61a1m1GekSec61a1m1GekSec61a1m1GekSec61a1m1Gek
• decreased body size_Sec61a1<m1Gek>/Sec61a1<m1Gek>
  http://metadb.riken.jp/0001265C57BL6JSec61a1m1GekSec61a1m1GekSec61a1m1GekSec61a1m1Gek
• increased circulating cholesterol level_Sec61a1<m1Gek>/Sec61a1<m1Gek>
  http://metadb.riken.jp/0005178C57BL6JSec61a1m1GekSec61a1m1GekSec61a1m1GekSec61a1m1Gek
• decreased circulating insulin level_Sec61a1<m1Gek>/Sec61a1<m1Gek>
  http://metadb.riken.jp/0002727C57BL6JSec61a1m1GekSec61a1m1GekSec61a1m1GekSec61a1m1Gek
• impaired glucose tolerance_Sec61a1<m1Gek>/Sec61a1<m1Gek>
  http://metadb.riken.jp/0005293C57BL6JSec61a1m1GekSec61a1m1GekSec61a1m1GekSec61a1m1Gek
• hepatic steatosis_Sec61a1<m1Gek>/Sec61a1<m1Gek>
  http://metadb.riken.jp/0002628C57BL6JSec61a1m1GekSec61a1m1GekSec61a1m1GekSec61a1m1Gek
• decreased lean body mass_Sec61a1<m1Gek>/Sec61a1<m1Gek>,Tg(Ins2-Sec61a1)#Gek/0
  http://metadb.riken.jp/0003961C57BL6Sec61a1m1GekTgIns2Sec61a1GekSec61a1m1GekSec61a1m1GekTgIns2Sec61a1Gek0TgIns2Sec61a1GekSec61a1m1Gek
• enlarged liver_Sec61a1<m1Gek>/Sec61a1<m1Gek>
  http://metadb.riken.jp/0000599C57BL6JSec61a1m1GekSec61a1m1GekSec61a1m1GekSec61a1m1Gek
• increased pancreatic alpha cell number_Sec61a1<m1Gek>/Sec61a1<m1Gek>
  http://metadb.riken.jp/0009176C57BL6JSec61a1m1GekSec61a1m1GekSec61a1m1GekSec61a1m1Gek
• increased pancreatic beta cell apoptosis_Sec61a1<m1Gek>/Sec61a1<m1Gek>
  http://metadb.riken.jp/0014117C57BL6JSec61a1m1GekSec61a1m1GekSec61a1m1GekSec61a1m1Gek
• abnormal pancreatic beta cell physiology_Sec61a1<m1Gek>/Sec61a1<m1Gek>
  http://metadb.riken.jp/0003562C57BL6JSec61a1m1GekSec61a1m1GekSec61a1m1GekSec61a1m1Gek
• hyperglycemia_Sec61a1<m1Gek>/Sec61a1<+>
  http://metadb.riken.jp/0001559C57BL6JSec61a1m1GekSec61a1m1GekSec61a1Sec61a1m1GekSec61a1
• abnormal pancreatic delta cell morphology_Sec61a1<m1Gek>/Sec61a1<m1Gek>
  http://metadb.riken.jp/0005218C57BL6JSec61a1m1GekSec61a1m1GekSec61a1m1GekSec61a1m1Gek
• enlarged liver_Sec61a1<m1Gek>/Sec61a1<m1Gek>,Tg(Ins2-Sec61a1)#Gek/0
  http://metadb.riken.jp/0000599C57BL6Sec61a1m1GekTgIns2Sec61a1GekSec61a1m1GekSec61a1m1GekTgIns2Sec61a1Gek0TgIns2Sec61a1GekSec61a1m1Gek
• increased hepatocyte proliferation_Sec61a1<m1Gek>/Sec61a1<m1Gek>
  http://metadb.riken.jp/0003893C57BL6JSec61a1m1GekSec61a1m1GekSec61a1m1GekSec61a1m1Gek
• decreased pancreatic beta cell number_Sec61a1<m1Gek>/Sec61a1<m1Gek>
  http://metadb.riken.jp/0003339C57BL6JSec61a1m1GekSec61a1m1GekSec61a1m1GekSec61a1m1Gek
• abnormal glucose homeostasis_Sec61a1<m1Gek>/Sec61a1<m1Gek>
  http://metadb.riken.jp/0002078C57BL6JSec61a1m1GekSec61a1m1GekSec61a1m1GekSec61a1m1Gek