Kira. Bettermann, et.al., TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer., Cancer cell, 2010, 17

http://rdf.ncbi.nlm.nih.gov/pubmed/20478530

Kira. Bettermann, et.al., TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer., Cancer cell, 2010, 17

http://rdf.ncbi.nlm.nih.gov/pubmed/

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD03127
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD03127

allele

http://purl.org/net/cito/citesAsAuthority

• Casp8<tm1Clie>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4461018

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal bile duct morphology_Casp8<tm1Clie>/Casp8<tm1Clie>,Map3k7<tm1Aki>/Map3k7<tm1Aki>,Tg(Alb1-cre)7Gsc/0
  http://metadb.riken.jp/0002928I129P2OlaHsdFVBNCasp8tm1ClieCasp8tm1ClieMap3k7tm1AkiMap3k7tm1AkiTgAlb1cre7Gsc0Map3k7tm1AkiCasp8tm1ClieTgAlb1cre7Gsc
• increased circulating alanine transaminase level_Casp8<tm1Clie>/Casp8<tm1Clie>,Map3k7<tm1Aki>/Map3k7<tm1Aki>,Tg(Alb1-cre)7Gsc/0
  http://metadb.riken.jp/0002941I129P2OlaHsdFVBNCasp8tm1ClieCasp8tm1ClieMap3k7tm1AkiMap3k7tm1AkiTgAlb1cre7Gsc0Map3k7tm1AkiCasp8tm1ClieTgAlb1cre7Gsc
• focal hepatic necrosis_Casp8<tm1Clie>/Casp8<tm1Clie>,Map3k7<tm1Aki>/Map3k7<tm1Aki>,Tg(Alb1-cre)7Gsc/0
  http://metadb.riken.jp/0001656I129P2OlaHsdFVBNCasp8tm1ClieCasp8tm1ClieMap3k7tm1AkiMap3k7tm1AkiTgAlb1cre7Gsc0Map3k7tm1AkiCasp8tm1ClieTgAlb1cre7Gsc
• premature death_Map3k7<tm1Aki>/Map3k7<tm1Aki>,Tg(Alb1-cre)7Gsc/0
  http://metadb.riken.jp/0002083I129P2OlaHsdFVBNMap3k7tm1AkiMap3k7tm1AkiTgAlb1cre7Gsc0Map3k7tm1AkiTgAlb1cre7Gsc
• increased circulating alanine transaminase level_Map3k7<tm1Aki>/Map3k7<tm1Aki>,Tg(Alb1-cre)7Gsc/0
  http://metadb.riken.jp/0002941I129P2OlaHsdFVBNMap3k7tm1AkiMap3k7tm1AkiTgAlb1cre7Gsc0Map3k7tm1AkiTgAlb1cre7Gsc
• increased circulating bilirubin level_Map3k7<tm1Aki>/Map3k7<tm1Aki>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005344I129P2OlaHsdC57BL6DBA2Map3k7tm1AkiMap3k7tm1AkiTgAlbcre21Mgn0Map3k7tm1AkiTgAlbcre21Mgn
• liver fibrosis_Map3k7<tm1Aki>/Map3k7<tm1Aki>,Tg(Alb1-cre)7Gsc/0
  http://metadb.riken.jp/0003333I129P2OlaHsdFVBNMap3k7tm1AkiMap3k7tm1AkiTgAlb1cre7Gsc0Map3k7tm1AkiTgAlb1cre7Gsc
• increased circulating bilirubin level_Map3k7<tm1Aki>/Map3k7<tm1Aki>,Tg(Alb1-cre)7Gsc/0
  http://metadb.riken.jp/0005344I129P2OlaHsdFVBNMap3k7tm1AkiMap3k7tm1AkiTgAlb1cre7Gsc0Map3k7tm1AkiTgAlb1cre7Gsc
• increased hepatocyte proliferation_Map3k7<tm1Aki>/Map3k7<tm1Aki>,Tg(Alb1-cre)7Gsc/0
  http://metadb.riken.jp/0003893I129P2OlaHsdFVBNMap3k7tm1AkiMap3k7tm1AkiTgAlb1cre7Gsc0Map3k7tm1AkiTgAlb1cre7Gsc
• increased circulating aspartate transaminase level_Ikbkg<tm1.1Chtr>/Ikbkg<tm1.1Chtr>,Map3k7<tm1Aki>/Map3k7<tm1Aki>,Tg(Alb1-cre)7Gsc/0
  http://metadb.riken.jp/0005343I129P2OlaHsdFVBNIkbkgtm11ChtrIkbkgtm11ChtrMap3k7tm1AkiMap3k7tm1AkiTgAlb1cre7Gsc0TgAlb1cre7GscMap3k7tm1AkiIkbkgtm11Chtr
• abnormal bile duct morphology_Map3k7<tm1Aki>/Map3k7<tm1Aki>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002928I129P2OlaHsdC57BL6DBA2Map3k7tm1AkiMap3k7tm1AkiTgAlbcre21Mgn0Map3k7tm1AkiTgAlbcre21Mgn
• increased hepatocellular carcinoma incidence_Map3k7<tm1Aki>/Map3k7<tm1Aki>,Tg(Alb1-cre)7Gsc/0
  http://metadb.riken.jp/0003331I129P2OlaHsdFVBNMap3k7tm1AkiMap3k7tm1AkiTgAlb1cre7Gsc0Map3k7tm1AkiTgAlb1cre7Gsc
• increased hepatocyte apoptosis_Ikbkg<tm1.1Chtr>/Ikbkg<tm1.1Chtr>,Map3k7<tm1Aki>/Map3k7<tm1Aki>,Tg(Alb1-cre)7Gsc/0
  http://metadb.riken.jp/0003887I129P2OlaHsdFVBNIkbkgtm11ChtrIkbkgtm11ChtrMap3k7tm1AkiMap3k7tm1AkiTgAlb1cre7Gsc0TgAlb1cre7GscMap3k7tm1AkiIkbkgtm11Chtr
• intrahepatic cholestasis_Map3k7<tm1Aki>/Map3k7<tm1Aki>,Tg(Alb1-cre)7Gsc/0
  http://metadb.riken.jp/0005415I129P2OlaHsdFVBNMap3k7tm1AkiMap3k7tm1AkiTgAlb1cre7Gsc0Map3k7tm1AkiTgAlb1cre7Gsc
• abnormal liver morphology_Map3k7<tm1Aki>/Map3k7<tm1Aki>,Tg(Alb1-cre)7Gsc/0
  http://metadb.riken.jp/0000598I129P2OlaHsdFVBNMap3k7tm1AkiMap3k7tm1AkiTgAlb1cre7Gsc0Map3k7tm1AkiTgAlb1cre7Gsc
• increased hepatocyte proliferation_Map3k7<tm1Aki>/Map3k7<tm1Aki>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0003893I129P2OlaHsdC57BL6DBA2Map3k7tm1AkiMap3k7tm1AkiTgAlbcre21Mgn0Map3k7tm1AkiTgAlbcre21Mgn
• bile duct proliferation_Casp8<tm1Clie>/Casp8<tm1Clie>,Map3k7<tm1Aki>/Map3k7<tm1Aki>,Tg(Alb1-cre)7Gsc/0
  http://metadb.riken.jp/0003255I129P2OlaHsdFVBNCasp8tm1ClieCasp8tm1ClieMap3k7tm1AkiMap3k7tm1AkiTgAlb1cre7Gsc0Map3k7tm1AkiCasp8tm1ClieTgAlb1cre7Gsc
• increased circulating aspartate transaminase level_Ikbkg<tm1.1Chtr>/Ikbkg<tm1.1Chtr>,Tg(Alb1-cre)7Gsc/0
  http://metadb.riken.jp/0005343IFVBNIkbkgtm11ChtrIkbkgtm11ChtrTgAlb1cre7Gsc0Ikbkgtm11ChtrTgAlb1cre7Gsc
• increased circulating alkaline phosphatase level_Map3k7<tm1Aki>/Map3k7<tm1Aki>,Tg(Alb1-cre)7Gsc/0
  http://metadb.riken.jp/0002968I129P2OlaHsdFVBNMap3k7tm1AkiMap3k7tm1AkiTgAlb1cre7Gsc0Map3k7tm1AkiTgAlb1cre7Gsc
• increased circulating alanine transaminase level_Ikbkg<tm1.1Chtr>/Ikbkg<tm1.1Chtr>,Tg(Alb1-cre)7Gsc/0
  http://metadb.riken.jp/0002941IFVBNIkbkgtm11ChtrIkbkgtm11ChtrTgAlb1cre7Gsc0Ikbkgtm11ChtrTgAlb1cre7Gsc
• increased circulating glutamate dehydrogenase level_Map3k7<tm1Aki>/Map3k7<tm1Aki>,Tg(Alb1-cre)7Gsc/0
  http://metadb.riken.jp/0011009I129P2OlaHsdFVBNMap3k7tm1AkiMap3k7tm1AkiTgAlb1cre7Gsc0Map3k7tm1AkiTgAlb1cre7Gsc
• increased hepatocyte proliferation_Ikbkg<tm1.1Chtr>/Ikbkg<tm1.1Chtr>,Tg(Alb1-cre)7Gsc/0
  http://metadb.riken.jp/0003893IFVBNIkbkgtm11ChtrIkbkgtm11ChtrTgAlb1cre7Gsc0Ikbkgtm11ChtrTgAlb1cre7Gsc
• abnormal liver morphology_Ikbkg<tm1.1Chtr>/Ikbkg<tm1.1Chtr>,Tg(Alb1-cre)7Gsc/0
  http://metadb.riken.jp/0000598IFVBNIkbkgtm11ChtrIkbkgtm11ChtrTgAlb1cre7Gsc0Ikbkgtm11ChtrTgAlb1cre7Gsc
• postnatal growth retardation_Casp8<tm1Clie>/Casp8<tm1Clie>,Map3k7<tm1Aki>/Map3k7<tm1Aki>,Tg(Alb1-cre)7Gsc/0
  http://metadb.riken.jp/0001732I129P2OlaHsdFVBNCasp8tm1ClieCasp8tm1ClieMap3k7tm1AkiMap3k7tm1AkiTgAlb1cre7Gsc0Map3k7tm1AkiCasp8tm1ClieTgAlb1cre7Gsc
• increased circulating bilirubin level_Casp8<tm1Clie>/Casp8<tm1Clie>,Map3k7<tm1Aki>/Map3k7<tm1Aki>,Tg(Alb1-cre)7Gsc/0
  http://metadb.riken.jp/0005344I129P2OlaHsdFVBNCasp8tm1ClieCasp8tm1ClieMap3k7tm1AkiMap3k7tm1AkiTgAlb1cre7Gsc0Map3k7tm1AkiCasp8tm1ClieTgAlb1cre7Gsc
• liver fibrosis_Ikbkg<tm1.1Chtr>/Ikbkg<tm1.1Chtr>,Tg(Alb1-cre)7Gsc/0
  http://metadb.riken.jp/0003333IFVBNIkbkgtm11ChtrIkbkgtm11ChtrTgAlb1cre7Gsc0Ikbkgtm11ChtrTgAlb1cre7Gsc
• abnormal hepatocyte morphology_Map3k7<tm1Aki>/Map3k7<tm1Aki>,Tg(Alb1-cre)7Gsc/0
  http://metadb.riken.jp/0000607I129P2OlaHsdFVBNMap3k7tm1AkiMap3k7tm1AkiTgAlb1cre7Gsc0Map3k7tm1AkiTgAlb1cre7Gsc
• focal hepatic necrosis_Map3k7<tm1Aki>/Map3k7<tm1Aki>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0001656I129P2OlaHsdC57BL6DBA2Map3k7tm1AkiMap3k7tm1AkiTgAlbcre21Mgn0Map3k7tm1AkiTgAlbcre21Mgn
• abnormal bile duct morphology_Map3k7<tm1Aki>/Map3k7<tm1Aki>,Tg(Alb1-cre)7Gsc/0
  http://metadb.riken.jp/0002928I129P2OlaHsdFVBNMap3k7tm1AkiMap3k7tm1AkiTgAlb1cre7Gsc0Map3k7tm1AkiTgAlb1cre7Gsc
• abnormal liver morphology_Casp8<tm1Clie>/Casp8<tm1Clie>,Map3k7<tm1Aki>/Map3k7<tm1Aki>,Tg(Alb1-cre)7Gsc/0
  http://metadb.riken.jp/0000598I129P2OlaHsdFVBNCasp8tm1ClieCasp8tm1ClieMap3k7tm1AkiMap3k7tm1AkiTgAlb1cre7Gsc0Map3k7tm1AkiCasp8tm1ClieTgAlb1cre7Gsc
• bile duct proliferation_Map3k7<tm1Aki>/Map3k7<tm1Aki>,Tg(Alb1-cre)7Gsc/0
  http://metadb.riken.jp/0003255I129P2OlaHsdFVBNMap3k7tm1AkiMap3k7tm1AkiTgAlb1cre7Gsc0Map3k7tm1AkiTgAlb1cre7Gsc
• increased hepatocellular carcinoma incidence_Ikbkg<tm1.1Chtr>/Ikbkg<tm1.1Chtr>,Tg(Alb1-cre)7Gsc/0
  http://metadb.riken.jp/0003331IFVBNIkbkgtm11ChtrIkbkgtm11ChtrTgAlb1cre7Gsc0Ikbkgtm11ChtrTgAlb1cre7Gsc
• abnormal hepatocyte morphology_Map3k7<tm1Aki>/Map3k7<tm1Aki>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0000607I129P2OlaHsdC57BL6DBA2Map3k7tm1AkiMap3k7tm1AkiTgAlbcre21Mgn0Map3k7tm1AkiTgAlbcre21Mgn
• increased hepatocyte apoptosis_Map3k7<tm1Aki>/Map3k7<tm1Aki>,Tg(Alb1-cre)7Gsc/0
  http://metadb.riken.jp/0003887I129P2OlaHsdFVBNMap3k7tm1AkiMap3k7tm1AkiTgAlb1cre7Gsc0Map3k7tm1AkiTgAlb1cre7Gsc
• increased circulating aspartate transaminase level_Casp8<tm1Clie>/Casp8<tm1Clie>,Map3k7<tm1Aki>/Map3k7<tm1Aki>,Tg(Alb1-cre)7Gsc/0
  http://metadb.riken.jp/0005343I129P2OlaHsdFVBNCasp8tm1ClieCasp8tm1ClieMap3k7tm1AkiMap3k7tm1AkiTgAlb1cre7Gsc0Map3k7tm1AkiCasp8tm1ClieTgAlb1cre7Gsc
• liver inflammation_Map3k7<tm1Aki>/Map3k7<tm1Aki>,Tg(Alb1-cre)7Gsc/0
  http://metadb.riken.jp/0001860I129P2OlaHsdFVBNMap3k7tm1AkiMap3k7tm1AkiTgAlb1cre7Gsc0Map3k7tm1AkiTgAlb1cre7Gsc
• increased circulating alanine transaminase level_Ikbkg<tm1.1Chtr>/Ikbkg<tm1.1Chtr>,Map3k7<tm1Aki>/Map3k7<tm1Aki>,Tg(Alb1-cre)7Gsc/0
  http://metadb.riken.jp/0002941I129P2OlaHsdFVBNIkbkgtm11ChtrIkbkgtm11ChtrMap3k7tm1AkiMap3k7tm1AkiTgAlb1cre7Gsc0TgAlb1cre7GscMap3k7tm1AkiIkbkgtm11Chtr
• increased circulating glutamate dehydrogenase level_Ikbkg<tm1.1Chtr>/Ikbkg<tm1.1Chtr>,Tg(Alb1-cre)7Gsc/0
  http://metadb.riken.jp/0011009IFVBNIkbkgtm11ChtrIkbkgtm11ChtrTgAlb1cre7Gsc0Ikbkgtm11ChtrTgAlb1cre7Gsc
• increased circulating aspartate transaminase level_Map3k7<tm1Aki>/Map3k7<tm1Aki>,Tg(Alb1-cre)7Gsc/0
  http://metadb.riken.jp/0005343I129P2OlaHsdFVBNMap3k7tm1AkiMap3k7tm1AkiTgAlb1cre7Gsc0Map3k7tm1AkiTgAlb1cre7Gsc
• focal hepatic necrosis_Map3k7<tm1Aki>/Map3k7<tm1Aki>,Tg(Alb1-cre)7Gsc/0
  http://metadb.riken.jp/0001656I129P2OlaHsdFVBNMap3k7tm1AkiMap3k7tm1AkiTgAlb1cre7Gsc0Map3k7tm1AkiTgAlb1cre7Gsc
• increased hepatocyte apoptosis_Ikbkg<tm1.1Chtr>/Ikbkg<tm1.1Chtr>,Tg(Alb1-cre)7Gsc/0
  http://metadb.riken.jp/0003887IFVBNIkbkgtm11ChtrIkbkgtm11ChtrTgAlb1cre7Gsc0Ikbkgtm11ChtrTgAlb1cre7Gsc
• increased hepatocyte proliferation_Ikbkg<tm1.1Chtr>/Ikbkg<tm1.1Chtr>,Map3k7<tm1Aki>/Map3k7<tm1Aki>,Tg(Alb1-cre)7Gsc/0
  http://metadb.riken.jp/0003893I129P2OlaHsdFVBNIkbkgtm11ChtrIkbkgtm11ChtrMap3k7tm1AkiMap3k7tm1AkiTgAlb1cre7Gsc0TgAlb1cre7GscMap3k7tm1AkiIkbkgtm11Chtr