Rita M. Tavares, et.al., The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity., Immunity, 2010, 33

http://rdf.ncbi.nlm.nih.gov/pubmed/20705491

Rita M. Tavares, et.al., The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity., Immunity, 2010, 33

http://rdf.ncbi.nlm.nih.gov/pubmed/

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD27626
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD27626

allele

http://purl.org/net/cito/citesAsAuthority

• Tnfaip3<tm2Ama>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4831001

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased immunoglobulin level_Tnfaip3<tm2Ama>/Tnfaip3<tm2Ama>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0002461I129P2OlaHsdC57BL6Tnfaip3tm2AmaTnfaip3tm2AmaCd19tm1creCgnCd19Tnfaip3tm2AmaCd19tm1creCgnCd19
• decreased B cell apoptosis_Tnfaip3<tm2Ama>/Tnfaip3<tm2Ama>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008783I129P2OlaHsdC57BL6Tnfaip3tm2AmaTnfaip3tm2AmaCd19tm1creCgnCd19Tnfaip3tm2AmaCd19tm1creCgnCd19
• increased B cell number_Tnfaip3<tm2Ama>/Tnfaip3<tm2Ama>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0005014I129P2OlaHsdC57BL6Tnfaip3tm2AmaTnfaip3tm2AmaCd19tm1creCgnCd19Tnfaip3tm2AmaCd19tm1creCgnCd19
• increased germinal center B cell number_Cd19<tm1(cre)Cgn>/Cd19<+>,Tnfaip3<tm2Ama>/Tnfaip3<+>
  http://metadb.riken.jp/0008177I129P2OlaHsdC57BL6Cd19tm1creCgnCd19Tnfaip3tm2AmaTnfaip3Tnfaip3tm2AmaCd19tm1creCgnTnfaip3Cd19
• abnormal B cell morphology_Tnfaip3<tm2Ama>/Tnfaip3<tm2Ama>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0004939I129P2OlaHsdC57BL6Tnfaip3tm2AmaTnfaip3tm2AmaCd19tm1creCgnCd19Tnfaip3tm2AmaCd19tm1creCgnCd19
• abnormal B-1a B cell morphology_Tnfaip3<tm2Ama>/Tnfaip3<tm2Ama>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008164I129P2OlaHsdC57BL6Tnfaip3tm2AmaTnfaip3tm2AmaCd19tm1creCgnCd19Tnfaip3tm2AmaCd19tm1creCgnCd19
• increased IgG level_Tnfaip3<tm2Ama>/Tnfaip3<tm2Ama>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0002493I129P2OlaHsdC57BL6Tnfaip3tm2AmaTnfaip3tm2AmaCd19tm1creCgnCd19Tnfaip3tm2AmaCd19tm1creCgnCd19
• increased IgM level_Tnfaip3<tm2Ama>/Tnfaip3<tm2Ama>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0002494I129P2OlaHsdC57BL6Tnfaip3tm2AmaTnfaip3tm2AmaCd19tm1creCgnCd19Tnfaip3tm2AmaCd19tm1creCgnCd19
• abnormal B cell activation_Tnfaip3<tm2Ama>/Tnfaip3<tm2Ama>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008217I129P2OlaHsdC57BL6Tnfaip3tm2AmaTnfaip3tm2AmaCd19tm1creCgnCd19Tnfaip3tm2AmaCd19tm1creCgnCd19
• increased immature B cell number_Tnfaip3<tm2Ama>/Tnfaip3<tm2Ama>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008214I129P2OlaHsdC57BL6Tnfaip3tm2AmaTnfaip3tm2AmaCd19tm1creCgnCd19Tnfaip3tm2AmaCd19tm1creCgnCd19
• increased immunoglobulin level_Cd19<tm1(cre)Cgn>/Cd19<+>,Tnfaip3<tm2Ama>/Tnfaip3<+>
  http://metadb.riken.jp/0002461I129P2OlaHsdC57BL6Cd19tm1creCgnCd19Tnfaip3tm2AmaTnfaip3Tnfaip3tm2AmaCd19tm1creCgnTnfaip3Cd19
• increased plasma cell number_Cd19<tm1(cre)Cgn>/Cd19<+>,Tnfaip3<tm2Ama>/Tnfaip3<+>
  http://metadb.riken.jp/0008097I129P2OlaHsdC57BL6Cd19tm1creCgnCd19Tnfaip3tm2AmaTnfaip3Tnfaip3tm2AmaCd19tm1creCgnTnfaip3Cd19
• increased susceptibility to autoimmune disorder_Cd19<tm1(cre)Cgn>/Cd19<+>,Tnfaip3<tm2Ama>/Tnfaip3<+>
  http://metadb.riken.jp/0005350I129P2OlaHsdC57BL6Cd19tm1creCgnCd19Tnfaip3tm2AmaTnfaip3Tnfaip3tm2AmaCd19tm1creCgnTnfaip3Cd19
• increased B cell proliferation_Tnfaip3<tm2Ama>/Tnfaip3<tm2Ama>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0005154I129P2OlaHsdC57BL6Tnfaip3tm2AmaTnfaip3tm2AmaCd19tm1creCgnCd19Tnfaip3tm2AmaCd19tm1creCgnCd19
• increased T cell number_Tnfaip3<tm2Ama>/Tnfaip3<tm2Ama>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0005015I129P2OlaHsdC57BL6Tnfaip3tm2AmaTnfaip3tm2AmaCd19tm1creCgnCd19Tnfaip3tm2AmaCd19tm1creCgnCd19
• increased interleukin-6 secretion_Tnfaip3<tm2Ama>/Tnfaip3<tm2Ama>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008705I129P2OlaHsdC57BL6Tnfaip3tm2AmaTnfaip3tm2AmaCd19tm1creCgnCd19Tnfaip3tm2AmaCd19tm1creCgnCd19
• increased autoantibody level_Cd19<tm1(cre)Cgn>/Cd19<+>,Tnfaip3<tm2Ama>/Tnfaip3<+>
  http://metadb.riken.jp/0003725I129P2OlaHsdC57BL6Cd19tm1creCgnCd19Tnfaip3tm2AmaTnfaip3Tnfaip3tm2AmaCd19tm1creCgnTnfaip3Cd19
• increased germinal center B cell number_Tnfaip3<tm2Ama>/Tnfaip3<tm2Ama>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008177I129P2OlaHsdC57BL6Tnfaip3tm2AmaTnfaip3tm2AmaCd19tm1creCgnCd19Tnfaip3tm2AmaCd19tm1creCgnCd19
• decreased B cell number_Tnfaip3<tm2Ama>/Tnfaip3<tm2Ama>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0005017I129P2OlaHsdC57BL6Tnfaip3tm2AmaTnfaip3tm2AmaCd19tm1creCgnCd19Tnfaip3tm2AmaCd19tm1creCgnCd19
• increased autoantibody level_Tnfaip3<tm2Ama>/Tnfaip3<tm2Ama>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0003725I129P2OlaHsdC57BL6Tnfaip3tm2AmaTnfaip3tm2AmaCd19tm1creCgnCd19Tnfaip3tm2AmaCd19tm1creCgnCd19
• increased plasma cell number_Tnfaip3<tm2Ama>/Tnfaip3<tm2Ama>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0008097I129P2OlaHsdC57BL6Tnfaip3tm2AmaTnfaip3tm2AmaCd19tm1creCgnCd19Tnfaip3tm2AmaCd19tm1creCgnCd19
• decreased B cell apoptosis_Cd19<tm1(cre)Cgn>/Cd19<+>,Tnfaip3<tm2Ama>/Tnfaip3<+>
  http://metadb.riken.jp/0008783I129P2OlaHsdC57BL6Cd19tm1creCgnCd19Tnfaip3tm2AmaTnfaip3Tnfaip3tm2AmaCd19tm1creCgnTnfaip3Cd19
• increased susceptibility to autoimmune disorder_Tnfaip3<tm2Ama>/Tnfaip3<tm2Ama>,Cd19<tm1(cre)Cgn>/Cd19<+>
  http://metadb.riken.jp/0005350I129P2OlaHsdC57BL6Tnfaip3tm2AmaTnfaip3tm2AmaCd19tm1creCgnCd19Tnfaip3tm2AmaCd19tm1creCgnCd19