Olivier. Demaria, et.al., TLR8 deficiency leads to autoimmunity in mice., The Journal of clinical investigation, 2010, 120

http://rdf.ncbi.nlm.nih.gov/pubmed/20811154

Olivier. Demaria, et.al., TLR8 deficiency leads to autoimmunity in mice., The Journal of clinical investigation, 2010, 120

http://rdf.ncbi.nlm.nih.gov/pubmed/

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD40490
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD40490

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased marginal zone B cell number_Tlr8/Tlr7<tm1Vlcg>/Tlr7<+>,Tlr8/Tlr7<tm1Vlcg>/Tlr8<tm1Vlcg>
  http://metadb.riken.jp/0008181B6CgTlr8Tlr7tm1VlcgTlr8tm1VlcgTlr8Tlr7tm1VlcgTlr7Tlr8Tlr7tm1VlcgTlr8tm1VlcgTlr8Tlr7tm1VlcgTlr8tm1VlcgTlr7
• decreased anti-insulin autoantibody level_Tlr8/Tlr7<tm1Vlcg>/Tlr8/Tlr7<tm1Vlcg>
  http://metadb.riken.jp/0002870B6CgTlr8Tlr7tm1VlcgTlr8Tlr7tm1VlcgTlr8Tlr7tm1VlcgTlr8Tlr7tm1Vlcg
• decreased marginal zone B cell number_Tlr8/Tlr7<tm1Vlcg>/Tlr7<+>,Tlr8/Tlr7<tm1Vlcg>/Tlr8<tm1Vlcg>
  http://metadb.riken.jp/0008182B6CgTlr8Tlr7tm1VlcgTlr8tm1VlcgTlr8Tlr7tm1VlcgTlr7Tlr8Tlr7tm1VlcgTlr8tm1VlcgTlr8Tlr7tm1VlcgTlr8tm1VlcgTlr7
• increased IgM level_Tlr8/Tlr7<tm1Vlcg>/Tlr7<+>,Tlr8/Tlr7<tm1Vlcg>/Tlr8<tm1Vlcg>
  http://metadb.riken.jp/0002494B6CgTlr8Tlr7tm1VlcgTlr8tm1VlcgTlr8Tlr7tm1VlcgTlr7Tlr8Tlr7tm1VlcgTlr8tm1VlcgTlr8Tlr7tm1VlcgTlr8tm1VlcgTlr7
• increased IgG2a level_Tlr8<tm1Vlcg>/Tlr8<tm1Vlcg>
  http://metadb.riken.jp/0008500B6129S1Tlr8tm1VlcgTlr8tm1VlcgTlr8tm1VlcgTlr8tm1Vlcg
• increased interleukin-6 secretion_Tlr8<tm1Vlcg>/Tlr8<tm1Vlcg>
  http://metadb.riken.jp/0008705B6129S1Tlr8tm1VlcgTlr8tm1VlcgTlr8tm1VlcgTlr8tm1Vlcg
• increased marginal zone B cell number_Tlr8/Tlr7<tm1Vlcg>/Tlr8/Tlr7<tm1Vlcg>
  http://metadb.riken.jp/0008181B6CgTlr8Tlr7tm1VlcgTlr8Tlr7tm1VlcgTlr8Tlr7tm1VlcgTlr8Tlr7tm1Vlcg
• decreased marginal zone B cell number_Tlr8<tm1Vlcg>/Tlr8<tm1Vlcg>
  http://metadb.riken.jp/0008182B6129S1Tlr8tm1VlcgTlr8tm1VlcgTlr8tm1VlcgTlr8tm1Vlcg
• increased IgM level_Tlr8<tm1Vlcg>/Tlr8<tm1Vlcg>
  http://metadb.riken.jp/0002494B6129S1Tlr8tm1VlcgTlr8tm1VlcgTlr8tm1VlcgTlr8tm1Vlcg
• increased spleen weight_Tlr8<tm1Vlcg>/Tlr8<tm1Vlcg>
  http://metadb.riken.jp/0004952B6129S1Tlr8tm1VlcgTlr8tm1VlcgTlr8tm1VlcgTlr8tm1Vlcg
• decreased IgG1 level_Tlr8<tm1Vlcg>/Tlr8<tm1Vlcg>
  http://metadb.riken.jp/0008495B6129S1Tlr8tm1VlcgTlr8tm1VlcgTlr8tm1VlcgTlr8tm1Vlcg
• enlarged spleen_Tlr8<tm1Vlcg>/Tlr8<tm1Vlcg>
  http://metadb.riken.jp/0000691B6129S1Tlr8tm1VlcgTlr8tm1VlcgTlr8tm1VlcgTlr8tm1Vlcg
• decreased IgG level_Tlr8/Tlr7<tm1Vlcg>/Tlr7<+>,Tlr8/Tlr7<tm1Vlcg>/Tlr8<tm1Vlcg>
  http://metadb.riken.jp/0001805B6CgTlr8Tlr7tm1VlcgTlr8tm1VlcgTlr8Tlr7tm1VlcgTlr7Tlr8Tlr7tm1VlcgTlr8tm1VlcgTlr8Tlr7tm1VlcgTlr8tm1VlcgTlr7
• decreased IgM level_Tlr7<tm1Flv>/Tlr7<tm1Flv>
  http://metadb.riken.jp/0001806B6129S1Tlr7tm1FlvTlr7tm1FlvTlr7tm1FlvTlr7tm1Flv
• increased IgG level_Tlr8/Tlr7<tm1Vlcg>/Tlr7<+>,Tlr8/Tlr7<tm1Vlcg>/Tlr8<tm1Vlcg>
  http://metadb.riken.jp/0002493B6CgTlr8Tlr7tm1VlcgTlr8tm1VlcgTlr8Tlr7tm1VlcgTlr7Tlr8Tlr7tm1VlcgTlr8tm1VlcgTlr8Tlr7tm1VlcgTlr8tm1VlcgTlr7
• increased circulating interleukin-12 level_Tlr8<tm1Vlcg>/Tlr8<tm1Vlcg>
  http://metadb.riken.jp/0008617B6129S1Tlr8tm1VlcgTlr8tm1VlcgTlr8tm1VlcgTlr8tm1Vlcg
• decreased IgG level_Tlr7<tm1Flv>/Tlr7<tm1Flv>
  http://metadb.riken.jp/0001805B6129S1Tlr7tm1FlvTlr7tm1FlvTlr7tm1FlvTlr7tm1Flv
• decreased IgG2a level_Tlr7<tm1Flv>/Tlr7<tm1Flv>
  http://metadb.riken.jp/0008496B6129S1Tlr7tm1FlvTlr7tm1FlvTlr7tm1FlvTlr7tm1Flv
• decreased dendritic cell number_Tlr8<tm1Vlcg>/Tlr8<tm1Vlcg>
  http://metadb.riken.jp/0008127B6129S1Tlr8tm1VlcgTlr8tm1VlcgTlr8tm1VlcgTlr8tm1Vlcg
• abnormal spleen marginal zone morphology_Tlr8<tm1Vlcg>/Tlr8<tm1Vlcg>
  http://metadb.riken.jp/0002362B6129S1Tlr8tm1VlcgTlr8tm1VlcgTlr8tm1VlcgTlr8tm1Vlcg
• decreased anti-insulin autoantibody level_Tlr7<tm1Flv>/Tlr7<tm1Flv>
  http://metadb.riken.jp/0002870B6129S1Tlr7tm1FlvTlr7tm1FlvTlr7tm1FlvTlr7tm1Flv
• increased IgG level_Tlr8<tm1Vlcg>/Tlr8<tm1Vlcg>
  http://metadb.riken.jp/0002493B6129S1Tlr8tm1VlcgTlr8tm1VlcgTlr8tm1VlcgTlr8tm1Vlcg
• decreased IgG1 level_Tlr7<tm1Flv>/Tlr7<tm1Flv>
  http://metadb.riken.jp/0008495B6129S1Tlr7tm1FlvTlr7tm1FlvTlr7tm1FlvTlr7tm1Flv
• decreased anti-insulin autoantibody level_Tlr8/Tlr7<tm1Vlcg>/Tlr7<+>,Tlr8/Tlr7<tm1Vlcg>/Tlr8<tm1Vlcg>
  http://metadb.riken.jp/0002870B6CgTlr8Tlr7tm1VlcgTlr8tm1VlcgTlr8Tlr7tm1VlcgTlr7Tlr8Tlr7tm1VlcgTlr8tm1VlcgTlr8Tlr7tm1VlcgTlr8tm1VlcgTlr7
• decreased follicular B cell number_Tlr8/Tlr7<tm1Vlcg>/Tlr8/Tlr7<tm1Vlcg>
  http://metadb.riken.jp/0008174B6CgTlr8Tlr7tm1VlcgTlr8Tlr7tm1VlcgTlr8Tlr7tm1VlcgTlr8Tlr7tm1Vlcg
• increased anti-nuclear antigen antibody level_Tlr8<tm1Vlcg>/Tlr8<tm1Vlcg>
  http://metadb.riken.jp/0004794B6129S1Tlr8tm1VlcgTlr8tm1VlcgTlr8tm1VlcgTlr8tm1Vlcg
• increased marginal zone B cell number_Tlr8/Tlr7<tm1Vlcg>/Tlr8/Tlr7<tm1Vlcg>
  http://metadb.riken.jp/0008181B6CgTlr8Tlr7tm1VlcgTlr8tm1VlcgTlr8Tlr7tm1VlcgTlr8Tlr7tm1VlcgTlr8Tlr7tm1Vlcg
• decreased B-1b cell number_Tlr8<tm1Vlcg>/Tlr8<tm1Vlcg>
  http://metadb.riken.jp/0008170B6129S1Tlr8tm1VlcgTlr8tm1VlcgTlr8tm1VlcgTlr8tm1Vlcg
• increased B-2 B cell number_Tlr8<tm1Vlcg>/Tlr8<tm1Vlcg>
  http://metadb.riken.jp/0008206B6129S1Tlr8tm1VlcgTlr8tm1VlcgTlr8tm1VlcgTlr8tm1Vlcg
• decreased anti-insulin autoantibody level_Tlr8/Tlr7<tm1Vlcg>/Tlr8/Tlr7<tm1Vlcg>
  http://metadb.riken.jp/0002870B6CgTlr8Tlr7tm1VlcgTlr8tm1VlcgTlr8Tlr7tm1VlcgTlr8Tlr7tm1VlcgTlr8Tlr7tm1Vlcg
• decreased B-1a cell number_Tlr8<tm1Vlcg>/Tlr8<tm1Vlcg>
  http://metadb.riken.jp/0008168B6129S1Tlr8tm1VlcgTlr8tm1VlcgTlr8tm1VlcgTlr8tm1Vlcg
• decreased IgM level_Tlr8/Tlr7<tm1Vlcg>/Tlr7<+>,Tlr8/Tlr7<tm1Vlcg>/Tlr8<tm1Vlcg>
  http://metadb.riken.jp/0001806B6CgTlr8Tlr7tm1VlcgTlr8tm1VlcgTlr8Tlr7tm1VlcgTlr7Tlr8Tlr7tm1VlcgTlr8tm1VlcgTlr8Tlr7tm1VlcgTlr8tm1VlcgTlr7
• decreased follicular B cell number_Tlr8/Tlr7<tm1Vlcg>/Tlr8/Tlr7<tm1Vlcg>
  http://metadb.riken.jp/0008174B6CgTlr8Tlr7tm1VlcgTlr8tm1VlcgTlr8Tlr7tm1VlcgTlr8Tlr7tm1VlcgTlr8Tlr7tm1Vlcg
• increased anti-double stranded DNA antibody level_Tlr8<tm1Vlcg>/Tlr8<tm1Vlcg>
  http://metadb.riken.jp/0004762B6129S1Tlr8tm1VlcgTlr8tm1VlcgTlr8tm1VlcgTlr8tm1Vlcg
• glomerulonephritis_Tlr8<tm1Vlcg>/Tlr8<tm1Vlcg>
  http://metadb.riken.jp/0002743B6129S1Tlr8tm1VlcgTlr8tm1VlcgTlr8tm1VlcgTlr8tm1Vlcg
• abnormal spleen marginal zone morphology_Tlr8/Tlr7<tm1Vlcg>/Tlr7<+>,Tlr8/Tlr7<tm1Vlcg>/Tlr8<tm1Vlcg>
  http://metadb.riken.jp/0002362B6CgTlr8Tlr7tm1VlcgTlr8tm1VlcgTlr8Tlr7tm1VlcgTlr7Tlr8Tlr7tm1VlcgTlr8tm1VlcgTlr8Tlr7tm1VlcgTlr8tm1VlcgTlr7