Elizabeth A. Slee, et.al., Phosphorylation of Ser312 contributes to tumor suppression by p53 in vivo., Proceedings of the National Academy of Sciences of the United States of America, 2010, 107

http://rdf.ncbi.nlm.nih.gov/pubmed/20962274

Elizabeth A. Slee, et.al., Phosphorylation of Ser312 contributes to tumor suppression by p53 in vivo., Proceedings of the National Academy of Sciences of the United States of America, 2010, 107

http://rdf.ncbi.nlm.nih.gov/pubmed/

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD48269
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD48269

allele

http://purl.org/net/cito/citesAsAuthority

• Trp53<tm1.1Xlu>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4840439

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• liver hyperplasia_Trp53<tm1.1Xlu>/Trp53<tm1.1Xlu>
  http://metadb.riken.jp/0005141I129S6SvEvTacC57BL6C57BL6JFVBNTrp53tm11XluTrp53tm11XluTrp53tm11Xlu
• increased liver tumor incidence_Trp53<tm1.1Xlu>/Trp53<tm1.1Xlu>
  http://metadb.riken.jp/0008019I129S6SvEvTacC57BL6C57BL6JFVBNTrp53tm11XluTrp53tm11XluTrp53tm11Xlu
• embryonic lethality during organogenesis, incomplete penetrance_Mdm4<Gt(VICTR20)7Lex>/Mdm4<Gt(VICTR20)7Lex>,Trp53<tm1.1Xlu>/Trp53<tm1.1Xlu>
  http://metadb.riken.jp/0011108I129S5SvEvBrd129S6SvEvTacC57BL6FVBNMdm4GtVICTR207LexMdm4GtVICTR207LexTrp53tm11XluTrp53tm11XluMdm4GtVICTR207LexTrp53tm11Xlu
• abnormal embryo development_Mdm4<Gt(VICTR20)7Lex>/Mdm4<Gt(VICTR20)7Lex>
  http://metadb.riken.jp/0001672I129S5SvEvBrd129S6SvEvTacC57BL6FVBNMdm4GtVICTR207LexMdm4GtVICTR207LexMdm4GtVICTR207Lex
• embryonic growth retardation_Mdm4<Gt(VICTR20)7Lex>/Mdm4<+>,Trp53<tm1.1Xlu>/Trp53<tm1.1Xlu>
  http://metadb.riken.jp/0003984I129S5SvEvBrd129S6SvEvTacC57BL6FVBNMdm4GtVICTR207LexMdm4Trp53tm11XluTrp53tm11XluMdm4Mdm4GtVICTR207LexTrp53tm11Xlu
• decreased cell proliferation_Mdm4<Gt(VICTR20)7Lex>/Mdm4<Gt(VICTR20)7Lex>
  http://metadb.riken.jp/0000352I129S5SvEvBrd129S6SvEvTacC57BL6FVBNMdm4GtVICTR207LexMdm4GtVICTR207LexMdm4GtVICTR207Lex
• increased lymphoma incidence_Trp53<tm1.1Xlu>/Trp53<tm1.1Xlu>
  http://metadb.riken.jp/0012431I129S6SvEvTacC57BL6C57BL6JFVBNTrp53tm11XluTrp53tm11XluTrp53tm11Xlu
• embryonic lethality during organogenesis, incomplete penetrance_Mdm4<Gt(VICTR20)7Lex>/Mdm4<Gt(VICTR20)7Lex>
  http://metadb.riken.jp/0011108I129S5SvEvBrd129S6SvEvTacC57BL6FVBNMdm4GtVICTR207LexMdm4GtVICTR207LexMdm4GtVICTR207Lex
• increased incidence of tumors by ionizing radiation induction_Trp53<tm1.1Xlu>/Trp53<tm1.1Xlu>
  http://metadb.riken.jp/0004500I129S6SvEvTacC57BL6C57BL6JFVBNTrp53tm11XluTrp53tm11XluTrp53tm11Xlu
• abnormal embryo development_Mdm4<Gt(VICTR20)7Lex>/Mdm4<+>,Trp53<tm1.1Xlu>/Trp53<tm1.1Xlu>
  http://metadb.riken.jp/0001672I129S5SvEvBrd129S6SvEvTacC57BL6FVBNMdm4GtVICTR207LexMdm4Trp53tm11XluTrp53tm11XluMdm4Mdm4GtVICTR207LexTrp53tm11Xlu
• embryonic lethality during organogenesis, incomplete penetrance_Mdm4<Gt(VICTR20)7Lex>/Mdm4<+>,Trp53<tm1.1Xlu>/Trp53<tm1.1Xlu>
  http://metadb.riken.jp/0011108I129S5SvEvBrd129S6SvEvTacC57BL6FVBNMdm4GtVICTR207LexMdm4Trp53tm11XluTrp53tm11XluMdm4Mdm4GtVICTR207LexTrp53tm11Xlu