Hsiao-Tuan. Chao, et.al., Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes., Nature, 2010, 468

http://rdf.ncbi.nlm.nih.gov/pubmed/21068835

Hsiao-Tuan. Chao, et.al., Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes., Nature, 2010, 468

http://rdf.ncbi.nlm.nih.gov/pubmed/

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD00766
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD00766

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(Slc32a1-cre)2.1Hzo
  http://metadb.riken.jp/db/mgi_rdf/MGI:4867735

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal social investigation_Mecp2<tm1Bird>/Y,Tg(dlx6a-cre)1Mekk/0
  http://metadb.riken.jp/0001360I129P2OlaHsd129S6SvEvTacCD1FVBNMecp2tm1BirdYTgdlx6acre1Mekk0Tgdlx6acre1MekkMecp2tm1Bird
• respiratory distress_Mecp2<tm1Bird>/Y,Tg(Slc32a1-cre)2.1Hzo/0
  http://metadb.riken.jp/0001954I129P2OlaHsd129S6SvEvTacFVBNMecp2tm1BirdYTgSlc32a1cre21Hzo0TgSlc32a1cre21HzoMecp2tm1Bird
• decreased startle reflex_Mecp2<tm1Bird>/Y,Tg(Slc32a1-cre)2.1Hzo/0
  http://metadb.riken.jp/0001489I129P2OlaHsd129S6SvEvTacFVBNMecp2tm1BirdYTgSlc32a1cre21Hzo0TgSlc32a1cre21HzoMecp2tm1Bird
• weight loss_Mecp2<tm1Bird>/Y,Tg(Slc32a1-cre)2.1Hzo/0
  http://metadb.riken.jp/0001263I129P2OlaHsd129S6SvEvTacFVBNMecp2tm1BirdYTgSlc32a1cre21Hzo0TgSlc32a1cre21HzoMecp2tm1Bird
• abnormal nervous system electrophysiology_Mecp2<tm1.1Bird>/Y
  http://metadb.riken.jp/0002272I129P2OlaHsdC57BL6JFVBNMecp2tm11BirdYMecp2tm11Bird
• reduced long term potentiation_Mecp2<tm1Bird>/Y,Tg(Slc32a1-cre)2.1Hzo/0
  http://metadb.riken.jp/0001473I129P2OlaHsd129S6SvEvTacFVBNMecp2tm1BirdYTgSlc32a1cre21Hzo0TgSlc32a1cre21HzoMecp2tm1Bird
• decreased startle reflex_Mecp2<tm1Bird>/Y,Tg(dlx6a-cre)1Mekk/0
  http://metadb.riken.jp/0001489I129P2OlaHsd129S6SvEvTacCD1FVBNMecp2tm1BirdYTgdlx6acre1Mekk0Tgdlx6acre1MekkMecp2tm1Bird
• increased stereotypic behavior_Mecp2<tm1Bird>/Y,Tg(Slc32a1-cre)2.1Hzo/0
  http://metadb.riken.jp/0001409I129P2OlaHsd129S6SvEvTacFVBNMecp2tm1BirdYTgSlc32a1cre21Hzo0TgSlc32a1cre21HzoMecp2tm1Bird
• abnormal nest building behavior_Mecp2<tm1Bird>/Y,Tg(Slc32a1-cre)2.1Hzo/0
  http://metadb.riken.jp/0001447I129P2OlaHsd129S6SvEvTacFVBNMecp2tm1BirdYTgSlc32a1cre21Hzo0TgSlc32a1cre21HzoMecp2tm1Bird
• abnormal social investigation_Mecp2<tm1Bird>/Y,Tg(Slc32a1-cre)2.1Hzo/0
  http://metadb.riken.jp/0001360I129P2OlaHsd129S6SvEvTacFVBNMecp2tm1BirdYTgSlc32a1cre21Hzo0TgSlc32a1cre21HzoMecp2tm1Bird
• seizures_Mecp2<tm1.1Bird>/Y
  http://metadb.riken.jp/0002064I129P2OlaHsdC57BL6JFVBNMecp2tm11BirdYMecp2tm11Bird
• abnormal nest building behavior_Mecp2<tm1Bird>/Y,Tg(dlx6a-cre)1Mekk/0
  http://metadb.riken.jp/0001447I129P2OlaHsd129S6SvEvTacCD1FVBNMecp2tm1BirdYTgdlx6acre1Mekk0Tgdlx6acre1MekkMecp2tm1Bird
• decreased tidal volume_Mecp2<tm1Bird>/Y,Tg(Slc32a1-cre)2.1Hzo/0
  http://metadb.riken.jp/0005586I129P2OlaHsd129S6SvEvTacFVBNMecp2tm1BirdYTgSlc32a1cre21Hzo0TgSlc32a1cre21HzoMecp2tm1Bird
• abnormal spatial learning_Mecp2<tm1Bird>/Y,Tg(Slc32a1-cre)2.1Hzo/0
  http://metadb.riken.jp/0001463I129P2OlaHsd129S6SvEvTacFVBNMecp2tm1BirdYTgSlc32a1cre21Hzo0TgSlc32a1cre21HzoMecp2tm1Bird
• decreased grip strength_Mecp2<tm1Bird>/Y,Tg(Slc32a1-cre)2.1Hzo/0
  http://metadb.riken.jp/0010053I129P2OlaHsd129S6SvEvTacFVBNMecp2tm1BirdYTgSlc32a1cre21Hzo0TgSlc32a1cre21HzoMecp2tm1Bird
• abnormal miniature inhibitory postsynaptic currents_Mecp2<tm1Bird>/Y,Tg(Slc32a1-cre)2.1Hzo/0
  http://metadb.riken.jp/0009435I129P2OlaHsd129S6SvEvTacFVBNMecp2tm1BirdYTgSlc32a1cre21Hzo0TgSlc32a1cre21HzoMecp2tm1Bird
• impaired coordination_Mecp2<tm1Bird>/Y,Tg(dlx6a-cre)1Mekk/0
  http://metadb.riken.jp/0001405I129P2OlaHsd129S6SvEvTacCD1FVBNMecp2tm1BirdYTgdlx6acre1Mekk0Tgdlx6acre1MekkMecp2tm1Bird
• hypoactivity_Mecp2<tm1Bird>/Y,Tg(Slc32a1-cre)2.1Hzo/0
  http://metadb.riken.jp/0001402I129P2OlaHsd129S6SvEvTacFVBNMecp2tm1BirdYTgSlc32a1cre21Hzo0TgSlc32a1cre21HzoMecp2tm1Bird
• apnea_Mecp2<tm1Bird>/Y,Tg(Slc32a1-cre)2.1Hzo/0
  http://metadb.riken.jp/0001957I129P2OlaHsd129S6SvEvTacFVBNMecp2tm1BirdYTgSlc32a1cre21Hzo0TgSlc32a1cre21HzoMecp2tm1Bird
• abnormal nervous system electrophysiology_Mecp2<tm1Bird>/Y,Tg(Slc32a1-cre)2.1Hzo/0
  http://metadb.riken.jp/0002272I129P2OlaHsd129S6SvEvTacFVBNMecp2tm1BirdYTgSlc32a1cre21Hzo0TgSlc32a1cre21HzoMecp2tm1Bird
• limb grasping_Mecp2<tm1Bird>/Y,Tg(Slc32a1-cre)2.1Hzo/0
  http://metadb.riken.jp/0001513I129P2OlaHsd129S6SvEvTacFVBNMecp2tm1BirdYTgSlc32a1cre21Hzo0TgSlc32a1cre21HzoMecp2tm1Bird
• abnormal breathing pattern_Mecp2<tm1Bird>/Y,Tg(Slc32a1-cre)2.1Hzo/0
  http://metadb.riken.jp/0001951I129P2OlaHsd129S6SvEvTacFVBNMecp2tm1BirdYTgSlc32a1cre21Hzo0TgSlc32a1cre21HzoMecp2tm1Bird
• increased grooming behavior_Mecp2<tm1Bird>/Y,Tg(Slc32a1-cre)2.1Hzo/0
  http://metadb.riken.jp/0001441I129P2OlaHsd129S6SvEvTacFVBNMecp2tm1BirdYTgSlc32a1cre21Hzo0TgSlc32a1cre21HzoMecp2tm1Bird
• premature death_Mecp2<tm1Bird>/Y,Tg(Slc32a1-cre)2.1Hzo/0
  http://metadb.riken.jp/0002083I129P2OlaHsd129S6SvEvTacFVBNMecp2tm1BirdYTgSlc32a1cre21Hzo0TgSlc32a1cre21HzoMecp2tm1Bird
• increased stereotypic behavior_Mecp2<tm1Bird>/Y,Tg(dlx6a-cre)1Mekk/0
  http://metadb.riken.jp/0001409I129P2OlaHsd129S6SvEvTacCD1FVBNMecp2tm1BirdYTgdlx6acre1Mekk0Tgdlx6acre1MekkMecp2tm1Bird
• increased prepulse inhibition_Mecp2<tm1Bird>/Y,Tg(Slc32a1-cre)2.1Hzo/0
  http://metadb.riken.jp/0009141I129P2OlaHsd129S6SvEvTacFVBNMecp2tm1BirdYTgSlc32a1cre21Hzo0TgSlc32a1cre21HzoMecp2tm1Bird
• abnormal miniature inhibitory postsynaptic currents_Mecp2<tm1.1Bird>/Y
  http://metadb.riken.jp/0009435I129P2OlaHsdC57BL6JFVBNMecp2tm11BirdYMecp2tm11Bird
• increased prepulse inhibition_Mecp2<tm1Bird>/Y,Tg(dlx6a-cre)1Mekk/0
  http://metadb.riken.jp/0009141I129P2OlaHsd129S6SvEvTacCD1FVBNMecp2tm1BirdYTgdlx6acre1Mekk0Tgdlx6acre1MekkMecp2tm1Bird
• impaired coordination_Mecp2<tm1Bird>/Y,Tg(Slc32a1-cre)2.1Hzo/0
  http://metadb.riken.jp/0001405I129P2OlaHsd129S6SvEvTacFVBNMecp2tm1BirdYTgSlc32a1cre21Hzo0TgSlc32a1cre21HzoMecp2tm1Bird
• abnormal respiratory function_Mecp2<tm1Bird>/Y,Tg(Slc32a1-cre)2.1Hzo/0
  http://metadb.riken.jp/0002327I129P2OlaHsd129S6SvEvTacFVBNMecp2tm1BirdYTgSlc32a1cre21Hzo0TgSlc32a1cre21HzoMecp2tm1Bird