Chris. Church, et.al., Overexpression of Fto leads to increased food intake and results in obesity., Nature genetics, 2010, 42

http://rdf.ncbi.nlm.nih.gov/pubmed/21076408

Chris. Church, et.al., Overexpression of Fto leads to increased food intake and results in obesity., Nature genetics, 2010, 42

http://rdf.ncbi.nlm.nih.gov/pubmed/

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD00783
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD00783

allele

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm1(CAG-Fto)Rdc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4879000
• Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4879001

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased food intake_Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>/Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>
  http://metadb.riken.jp/0011939I129S1Sv129X1SvJC57BL6JSJLGtROSA26Sortm11CAGFtoRdcGtROSA26Sortm11CAGFtoRdcGtROSA26Sortm11CAGFtoRdc
• increased total body fat amount_Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>/Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>
  http://metadb.riken.jp/0010024I129S1Sv129X1SvJC57BL6JSJLGtROSA26Sortm11CAGFtoRdcGtROSA26Sortm11CAGFtoRdcGtROSA26Sortm11CAGFtoRdc
• abnormal hormone level_Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0003953I129S1Sv129X1SvJC57BL6JSJLGtROSA26Sortm11CAGFtoRdcGtROSA26SorGtROSA26SorGtROSA26Sortm11CAGFtoRdc
• increased circulating leptin level_Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0005669I129S1Sv129X1SvJC57BL6JSJLGtROSA26Sortm11CAGFtoRdcGtROSA26SorGtROSA26SorGtROSA26Sortm11CAGFtoRdc
• increased lean body mass_Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0003960I129S1Sv129X1SvJC57BL6JSJLGtROSA26Sortm11CAGFtoRdcGtROSA26SorGtROSA26SorGtROSA26Sortm11CAGFtoRdc
• abnormal circulating lipid level_Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0003949I129S1Sv129X1SvJC57BL6JSJLGtROSA26Sortm11CAGFtoRdcGtROSA26SorGtROSA26SorGtROSA26Sortm11CAGFtoRdc
• increased circulating HDL cholesterol level_Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>/Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>
  http://metadb.riken.jp/0001556I129S1Sv129X1SvJC57BL6JSJLGtROSA26Sortm11CAGFtoRdcGtROSA26Sortm11CAGFtoRdcGtROSA26Sortm11CAGFtoRdc
• increased susceptibility to diet-induced obesity_Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>/Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>
  http://metadb.riken.jp/0005658I129S1Sv129X1SvJC57BL6JSJLGtROSA26Sortm11CAGFtoRdcGtROSA26Sortm11CAGFtoRdcGtROSA26Sortm11CAGFtoRdc
• increased body weight_Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>/Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>
  http://metadb.riken.jp/0001260I129S1Sv129X1SvJC57BL6JSJLGtROSA26Sortm11CAGFtoRdcGtROSA26Sortm11CAGFtoRdcGtROSA26Sortm11CAGFtoRdc
• increased energy expenditure_Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>/Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>
  http://metadb.riken.jp/0004889I129S1Sv129X1SvJC57BL6JSJLGtROSA26Sortm11CAGFtoRdcGtROSA26Sortm11CAGFtoRdcGtROSA26Sortm11CAGFtoRdc
• impaired glucose tolerance_Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>/Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>
  http://metadb.riken.jp/0005293I129S1Sv129X1SvJC57BL6JSJLGtROSA26Sortm11CAGFtoRdcGtROSA26Sortm11CAGFtoRdcGtROSA26Sortm11CAGFtoRdc
• increased susceptibility to diet-induced obesity_Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0005658I129S1Sv129X1SvJC57BL6JSJLGtROSA26Sortm11CAGFtoRdcGtROSA26SorGtROSA26SorGtROSA26Sortm11CAGFtoRdc
• increased abdominal fat pad weight_Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0009286I129S1Sv129X1SvJC57BL6JSJLGtROSA26Sortm11CAGFtoRdcGtROSA26SorGtROSA26SorGtROSA26Sortm11CAGFtoRdc
• decreased circulating leptin level_Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>/Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>
  http://metadb.riken.jp/0005668I129S1Sv129X1SvJC57BL6JSJLGtROSA26Sortm11CAGFtoRdcGtROSA26Sortm11CAGFtoRdcGtROSA26Sortm11CAGFtoRdc
• decreased adiponectin level_Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>/Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>
  http://metadb.riken.jp/0004893I129S1Sv129X1SvJC57BL6JSJLGtROSA26Sortm11CAGFtoRdcGtROSA26Sortm11CAGFtoRdcGtROSA26Sortm11CAGFtoRdc
• increased total body fat amount_Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0010024I129S1Sv129X1SvJC57BL6JSJLGtROSA26Sortm11CAGFtoRdcGtROSA26SorGtROSA26SorGtROSA26Sortm11CAGFtoRdc
• increased body weight_Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0001260I129S1Sv129X1SvJC57BL6JSJLGtROSA26Sortm11CAGFtoRdcGtROSA26SorGtROSA26SorGtROSA26Sortm11CAGFtoRdc
• increased circulating triglyceride level_Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>/Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>
  http://metadb.riken.jp/0001552I129S1Sv129X1SvJC57BL6JSJLGtROSA26Sortm11CAGFtoRdcGtROSA26Sortm11CAGFtoRdcGtROSA26Sortm11CAGFtoRdc
• increased circulating insulin level_Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>/Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>
  http://metadb.riken.jp/0002079I129S1Sv129X1SvJC57BL6JSJLGtROSA26Sortm11CAGFtoRdcGtROSA26Sortm11CAGFtoRdcGtROSA26Sortm11CAGFtoRdc
• increased circulating free fatty acid level_Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0001554I129S1Sv129X1SvJC57BL6JSJLGtROSA26Sortm11CAGFtoRdcGtROSA26SorGtROSA26SorGtROSA26Sortm11CAGFtoRdc
• decreased adiponectin level_Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0004893I129S1Sv129X1SvJC57BL6JSJLGtROSA26Sortm11CAGFtoRdcGtROSA26SorGtROSA26SorGtROSA26Sortm11CAGFtoRdc
• abnormal circulating lipid level_Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>/Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>
  http://metadb.riken.jp/0003949I129S1Sv129X1SvJC57BL6JSJLGtROSA26Sortm11CAGFtoRdcGtROSA26Sortm11CAGFtoRdcGtROSA26Sortm11CAGFtoRdc
• increased lean body mass_Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>/Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>
  http://metadb.riken.jp/0003960I129S1Sv129X1SvJC57BL6JSJLGtROSA26Sortm11CAGFtoRdcGtROSA26Sortm11CAGFtoRdcGtROSA26Sortm11CAGFtoRdc
• increased circulating triglyceride level_Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0001552I129S1Sv129X1SvJC57BL6JSJLGtROSA26Sortm11CAGFtoRdcGtROSA26SorGtROSA26SorGtROSA26Sortm11CAGFtoRdc
• increased circulating free fatty acid level_Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>/Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>
  http://metadb.riken.jp/0001554I129S1Sv129X1SvJC57BL6JSJLGtROSA26Sortm11CAGFtoRdcGtROSA26Sortm11CAGFtoRdcGtROSA26Sortm11CAGFtoRdc
• increased abdominal fat pad weight_Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>/Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>
  http://metadb.riken.jp/0009286I129S1Sv129X1SvJC57BL6JSJLGtROSA26Sortm11CAGFtoRdcGtROSA26Sortm11CAGFtoRdcGtROSA26Sortm11CAGFtoRdc
• increased food intake_Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0011939I129S1Sv129X1SvJC57BL6JSJLGtROSA26Sortm11CAGFtoRdcGtROSA26SorGtROSA26SorGtROSA26Sortm11CAGFtoRdc
• decreased circulating LDL cholesterol level_Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0000183I129S1Sv129X1SvJC57BL6JSJLGtROSA26Sortm11CAGFtoRdcGtROSA26SorGtROSA26SorGtROSA26Sortm11CAGFtoRdc
• decreased circulating LDL cholesterol level_Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>/Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>
  http://metadb.riken.jp/0000183I129S1Sv129X1SvJC57BL6JSJLGtROSA26Sortm11CAGFtoRdcGtROSA26Sortm11CAGFtoRdcGtROSA26Sortm11CAGFtoRdc
• increased circulating HDL cholesterol level_Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0001556I129S1Sv129X1SvJC57BL6JSJLGtROSA26Sortm11CAGFtoRdcGtROSA26SorGtROSA26SorGtROSA26Sortm11CAGFtoRdc
• abnormal hormone level_Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>/Gt(ROSA)26Sor<tm1.1(CAG-Fto)Rdc>
  http://metadb.riken.jp/0003953I129S1Sv129X1SvJC57BL6JSJLGtROSA26Sortm11CAGFtoRdcGtROSA26Sortm11CAGFtoRdcGtROSA26Sortm11CAGFtoRdc