CD04972

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD04972

CD04972

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Brca2

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• breast cancer 2

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• breast cancer 2
• fanconi anemia group D1 protein homolog
• breast cancer type 2 susceptibility protein homolog

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• Fancd1
• RAB163
• AW045498
• AI256696

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/12190

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• breast cancer 2, early onset
  http://metadb.riken.jp/db/mgi_rdf/MGI:109337

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_001081001
• https://www.ncbi.nlm.nih.gov/nuccore/NM_009765

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000041147

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.236256

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=600185

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• G. Bignell, et.al., The BRC repeats are conserved in mammalian BRCA2 proteins., Human molecular genetics, 1997, 6
  http://rdf.ncbi.nlm.nih.gov/pubmed/9002670
• T. Miyakawa, et.al., Radial maze performance, open-field and elevated plus-maze behaviors in Fyn-kinase deficient mice: further evidence for increased fearfulness., Brain research. Molecular brain research, 1996, 37
  http://rdf.ncbi.nlm.nih.gov/pubmed/8738145
• F. Connor, et.al., Cloning, chromosomal mapping and expression pattern of the mouse Brca2 gene., Human molecular genetics, 1997, 6
  http://rdf.ncbi.nlm.nih.gov/pubmed/9063750
• Ferdinandos. Skoulidis, et.al., Germline Brca2 heterozygosity promotes Kras(G12D) -driven carcinogenesis in a murine model of familial pancreatic cancer., Cancer cell, 2010, 18
  http://rdf.ncbi.nlm.nih.gov/pubmed/21056012
• Yvette. Drew, et.al., Therapeutic potential of poly(ADP-ribose) polymerase inhibitor AG014699 in human cancers with mutated or methylated BRCA1 or BRCA2., Journal of the National Cancer Institute, 2011, 103
  http://rdf.ncbi.nlm.nih.gov/pubmed/21183737
• J V. Rajan, et.al., Brca2 is coordinately regulated with Brca1 during proliferation and differentiation in mammary epithelial cells., Proceedings of the National Academy of Sciences of the United States of America, 1996, 93
  http://rdf.ncbi.nlm.nih.gov/pubmed/8917547
• S K. Sharan, et.al., Identification and characterization of a microsatellite marker within murine Brca2 gene., Mammalian genome : official journal of the International Mammalian Genome Society, 1997, 8
  http://rdf.ncbi.nlm.nih.gov/pubmed/9021166
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• George. Sioftanos, et.al., BRCA1 and BRCA2 heterozygosity in embryonic stem cells reduces radiation-induced Rad51 focus formation but is not associated with radiosensitivity., International journal of radiation biology, 2010, 86
  http://rdf.ncbi.nlm.nih.gov/pubmed/20979543
• Sophie. Badie, et.al., BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping., Nature structural & molecular biology, 2010, 17
  http://rdf.ncbi.nlm.nih.gov/pubmed/21076401

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• oocyte maturation
  http://purl.obolibrary.org/obo/GO_0001556
• centrosome duplication
  http://purl.obolibrary.org/obo/GO_0051298
• response to X-ray
  http://purl.obolibrary.org/obo/GO_0010165
• positive regulation of mitotic cell cycle
  http://purl.obolibrary.org/obo/GO_0045931
• cell aging
  http://purl.obolibrary.org/obo/GO_0007569
• DNA repair
  http://purl.obolibrary.org/obo/GO_0006281
• response to UV-C
  http://purl.obolibrary.org/obo/GO_0010225
• brain development
  http://purl.obolibrary.org/obo/GO_0007420
• BRCA2-MAGE-D1 complex
  http://purl.obolibrary.org/obo/GO_0033593
• single-stranded DNA binding
  http://purl.obolibrary.org/obo/GO_0003697
• response to gamma radiation
  http://purl.obolibrary.org/obo/GO_0010332
• regulation of cytokinesis
  http://purl.obolibrary.org/obo/GO_0032465
• spermatogenesis
  http://purl.obolibrary.org/obo/GO_0007283
• positive regulation of transcription, DNA-templated
  http://purl.obolibrary.org/obo/GO_0045893
• replication fork protection
  http://purl.obolibrary.org/obo/GO_0048478
• centrosome
  http://purl.obolibrary.org/obo/GO_0005813
• chordate embryonic development
  http://purl.obolibrary.org/obo/GO_0043009
• intracellular
  http://purl.obolibrary.org/obo/GO_0005622
• histone H4 acetylation
  http://purl.obolibrary.org/obo/GO_0043967
• H3 histone acetyltransferase activity
  http://purl.obolibrary.org/obo/GO_0010484
• inner cell mass cell proliferation
  http://purl.obolibrary.org/obo/GO_0001833
• mammary gland development
  http://purl.obolibrary.org/obo/GO_0030879
• double-strand break repair
  http://purl.obolibrary.org/obo/GO_0006302
• negative regulation of mammary gland epithelial cell proliferation
  http://purl.obolibrary.org/obo/GO_0033600
• nucleotide-excision repair
  http://purl.obolibrary.org/obo/GO_0006289
• regulation of S phase of mitotic cell cycle
  http://purl.obolibrary.org/obo/GO_0007090
• DNA recombination
  http://purl.obolibrary.org/obo/GO_0006310
• female gonad development
  http://purl.obolibrary.org/obo/GO_0008585
• intrinsic apoptotic signaling pathway in response to DNA damage
  http://purl.obolibrary.org/obo/GO_0008630
• regulation of cell proliferation
  http://purl.obolibrary.org/obo/GO_0042127
• hemopoiesis
  http://purl.obolibrary.org/obo/GO_0030097
• intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
  http://purl.obolibrary.org/obo/GO_0042771
• cell proliferation
  http://purl.obolibrary.org/obo/GO_0008283
• single-stranded DNA binding
  http://purl.obolibrary.org/obo/GO_0006330
• DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
  http://purl.obolibrary.org/obo/GO_0006978
• gamma-tubulin binding
  http://purl.obolibrary.org/obo/GO_0043015
• male meiosis I
  http://purl.obolibrary.org/obo/GO_0007141
• cytokinesis
  http://purl.obolibrary.org/obo/GO_0000910
• histone H3 acetylation
  http://purl.obolibrary.org/obo/GO_0043966
• secretory granule
  http://purl.obolibrary.org/obo/GO_0030141
• multicellular organism growth
  http://purl.obolibrary.org/obo/GO_0035264
• double-strand break repair via homologous recombination
  http://purl.obolibrary.org/obo/GO_0000724
• macromolecular complex
  http://purl.obolibrary.org/obo/GO_0032991
• protease binding
  http://purl.obolibrary.org/obo/GO_0002020
• cell cycle
  http://purl.obolibrary.org/obo/GO_0007049
• nucleus
  http://purl.obolibrary.org/obo/GO_0005634
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• homologous chromosome orientation involved in meiotic metaphase I plate congression
  http://purl.obolibrary.org/obo/GO_0031619
• DNA binding
  http://purl.obolibrary.org/obo/GO_0003677
• cellular response to DNA damage stimulus
  http://purl.obolibrary.org/obo/GO_0006974
• H4 histone acetyltransferase activity
  http://purl.obolibrary.org/obo/GO_0010485
• chromosome organization
  http://purl.obolibrary.org/obo/GO_0051276

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map03460
• http://www.genome.jp/dbget-bin/www_bget?map05212
• http://www.genome.jp/dbget-bin/www_bget?map03440
• http://www.genome.jp/dbget-bin/www_bget?map05200

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Homologous recombination
• Fanconi anemia pathway
• Pancreatic cancer
• Pathways in cancer