CD05547

http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD05547

CD05547

トランスクリプトームデータ

遺伝子シンボル

http://metadb.riken.jp/db/BrainTx/geneSymbol

• Pias3

遺伝子名

http://metadb.riken.jp/db/BrainTx/geneName

• protein inhibitor of activated STAT 3

別名

http://metadb.riken.jp/db/BrainTx/alt_name

• protein inhibitor of activated STAT protein 3
• E3 SUMO-protein ligase PIAS3
• protein inhibitor of activated STAT 3

別名略称

http://metadb.riken.jp/db/BrainTx/alt_symbol

• Pias3l
• Pias3L

NCBI遺伝子

http://metadb.riken.jp/db/BrainTx/NCBIGene

• https://www.ncbi.nlm.nih.gov/gene/229615

MGI遺伝子

http://metadb.riken.jp/db/BrainTx/mgiGene

• protein inhibitor of activated STAT 3
  http://metadb.riken.jp/db/mgi_rdf/MGI:1913126

BrainTx遺伝子

http://metadb.riken.jp/db/BrainTx/brainTxGene

脳発現画像

http://metadb.riken.jp/db/BrainTx/brainExpressionImage

時系列発現 (小脳)

http://metadb.riken.jp/db/BrainTx/brainExpression

脳発現特異性/組織別発現

http://metadb.riken.jp/db/BrainTx/brainSpecificity

BrainTx遺伝子カテゴリー

http://metadb.riken.jp/db/BrainTx/brainTxGeneCategory

NCBI Accession Number

http://metadb.riken.jp/db/BrainTx/NCBIAccessionNumber

• https://www.ncbi.nlm.nih.gov/nuccore/NM_018812
• https://www.ncbi.nlm.nih.gov/nuccore/NM_146135
• https://www.ncbi.nlm.nih.gov/nuccore/NM_001165949

Ensembl 遺伝子

http://metadb.riken.jp/db/BrainTx/ensemblGene

• http://asia.ensembl.org/Mus_musculus/Gene/Summary?g=ENSMUSG00000028101

UniGene 遺伝子

http://metadb.riken.jp/db/BrainTx/uniGene

• https://www.ncbi.nlm.nih.gov/unigene/?term=Mm.1635

OMIM ID

http://metadb.riken.jp/db/BrainTx/omim

• https://www.omim.org/entry/603434?search=603434&highlight=605987

PubMed ID (PMID)

http://rdf.ncbi.nlm.nih.gov/pubmed/

• C D. Chung, et.al., Specific inhibition of Stat3 signal transduction by PIAS3., Science (New York, N.Y.), 1997, 278
  http://rdf.ncbi.nlm.nih.gov/pubmed/9388184
• N. Kotaja, et.al., ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation., Molecular endocrinology (Baltimore, Md.), 2000, 14
  http://rdf.ncbi.nlm.nih.gov/pubmed/11117529
• Graciana. Diez-Roux, et.al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo., PLoS biology, 2011, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/21267068
• Yue. Peng, et.al., A novel role for protein inhibitor of activated STAT (PIAS) proteins in modulating the activity of Zimp7, a novel PIAS-like protein, in androgen receptor-mediated transcription., The Journal of biological chemistry, 2010, 285
  http://rdf.ncbi.nlm.nih.gov/pubmed/20159969
• Akishi. Onishi, et.al., Pias3-dependent SUMOylation controls mammalian cone photoreceptor differentiation., Nature neuroscience, 2010, 13
  http://rdf.ncbi.nlm.nih.gov/pubmed/20729845
• Guoji. Guo, et.al., Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst., Developmental cell, 2010, 18
  http://rdf.ncbi.nlm.nih.gov/pubmed/20412781
• http://rdf.ncbi.nlm.nih.gov/pubmed/10854042
• Fumihiko. Okumura, et.al., TRIM8 modulates STAT3 activity through negative regulation of PIAS3., Journal of cell science, 2010, 123
  http://rdf.ncbi.nlm.nih.gov/pubmed/20516148
• M D. Zentner, et.al., Requirement for high mobility group protein HMGI-C interaction with STAT3 inhibitor PIAS3 in repression of alpha-subunit of epithelial Na+ channel (alpha-ENaC) transcription by Ras activation in salivary epithelial cells., The Journal of biological chemistry, 2001, 276
  http://rdf.ncbi.nlm.nih.gov/pubmed/11390395
• B. Rödel, et.al., The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3., The EMBO journal, 2000, 19
  http://rdf.ncbi.nlm.nih.gov/pubmed/11060035

Gene Ontology

http://metadb.riken.jp/db/BrainTx/golink

• synapse
  http://purl.obolibrary.org/obo/GO_0045202
• protein binding
  http://purl.obolibrary.org/obo/GO_0005515
• nucleic acid binding
  http://purl.obolibrary.org/obo/GO_0003676
• protein C-terminus binding
  http://purl.obolibrary.org/obo/GO_0008022
• positive regulation of membrane potential
  http://purl.obolibrary.org/obo/GO_0045838
• cytoplasm
  http://purl.obolibrary.org/obo/GO_0005737
• positive regulation of protein sumoylation
  http://purl.obolibrary.org/obo/GO_0033235
• metal ion binding
  http://purl.obolibrary.org/obo/GO_0046872
• protein sumoylation
  http://purl.obolibrary.org/obo/GO_0016925
• enzyme binding
  http://purl.obolibrary.org/obo/GO_0019899
• zinc ion binding
  http://purl.obolibrary.org/obo/GO_0008270
• positive regulation of gene expression
  http://purl.obolibrary.org/obo/GO_0010628
• protein N-terminus binding
  http://purl.obolibrary.org/obo/GO_0047485
• SUMO ligase activity
  http://purl.obolibrary.org/obo/GO_0061665
• transcription, DNA-templated
  http://purl.obolibrary.org/obo/GO_0006351
• potassium channel regulator activity
  http://purl.obolibrary.org/obo/GO_0015459
• nucleus
  http://purl.obolibrary.org/obo/GO_0005634
• dendrite
  http://purl.obolibrary.org/obo/GO_0030425
• regulation of transcription, DNA-templated
  http://purl.obolibrary.org/obo/GO_0006355

InterPro ID

http://metadb.riken.jp/db/BrainTx/interPro

KEGG Pathway ID

http://metadb.riken.jp/db/BrainTx/keggPathwayID

• http://www.genome.jp/dbget-bin/www_bget?map05200
• http://www.genome.jp/dbget-bin/www_bget?map04630
• http://www.genome.jp/dbget-bin/www_bget?map04120
• http://www.genome.jp/dbget-bin/www_bget?map05222
• http://www.genome.jp/dbget-bin/www_bget?map05160

KEGG Pathway 名称

http://metadb.riken.jp/db/BrainTx/keggPathwayName

• Small cell lung cancer
• Hepatitis C
• Jak-STAT signaling pathway
• Ubiquitin mediated proteolysis
• Pathways in cancer