Hormonally upregulated Neu-associated kinase

Hormonally upregulated Neu-associated kinase(InterPro Protein Domain record)

URI表示モード

Hormonally upregulated Neu-associated kinase

InterPro Protein Domain record

description http://metadb.riken.jp/db/SciNetS_rib124i/prib124u1i

Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity [<cite idref="PUB00005115"/>]: <ul> <li>Serine/threonine-protein kinases</li><li>Tyrosine-protein kinases</li><li>Dual specific protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)</li> </ul> Protein kinase function has been evolutionarily conserved from <taxon tax_id="562">Escherichia coli</taxon> to human [<cite idref="PUB00020114"/>]. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation [<cite idref="PUB00015362"/>]. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [<cite idref="PUB00034898"/>], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [<cite idref="PUB00034899"/>].Eukaryotic protein kinases [<cite idref="PUB00001530"/>, <cite idref="PUB00003568"/>, <cite idref="PUB00003569"/>, <cite idref="PUB00005115"/>] are enzymes that belong to a very extensive group of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This family represents protein kinase Hunk (hormonally upregulated neu-associated kinase), expressed in the murine mammary gland. Hunk is most closely related to the SNF1 family of serine/threonine kinases and contains a SNF1 homology domain [<cite idref="PUB00034850"/>]. Hunk is also described as the MAK-V protein kinase, which interacts with Rabaptin-5, a protein which plays an important role in endocytosis [<cite idref="PUB00034851"/>]. Synonym(s): MAK-V.

label http://www.w3.org/2000/01/rdf-schema#label