<p>This region tends to appear at the N terminus of proteins also containing DNA-binding HMG (high mobility group) boxes (<db_xref db="INTERPRO" dbkey="IPR000910"/>) and appears to bind the armadillo repeat of CTNNB1 (beta-catenin), forming a stable complex. Signalling by Wnt through TCF/LCF is involved in developmental patterning, induction of neural tissues, cell fate decisions and stem cell differentiation [<cite idref="PUB00020946"/>]. Isoforms of HMG T-cell factors lacking the N-terminal CTNNB1-binding domain cannot fulfil their role as transcriptional activators in T-cell differentiation [<cite idref="PUB00020853"/>, <cite idref="PUB00020874"/>]. </p>