<p>These proteins, mainly from ascomycetes but with distant relatives in Giardia intestinalis, contain one copy of the calcineurin-like phosphoesterase domain (<db_xref db="INTERPRO" dbkey="IPR004843"/>), followed by a C-terminal extension. They possess motifs characteristic of a variety of enzymatically active phosphoesterases [<cite idref="PUB00014394"/>], including acid and alkaline phosphatases, phosphoprotein phosphatases, 5'-nucleotidase, bis(5'-nucleosyl)-tetraphosphatase (symmetrical), sphingomyelin phosphodiesterase, 2'3'-cylic-nucleotide 2'-phosphodiesterase, and 3'5'-nucleotide phosphodiesterase CpdA.</p>