<p>Mre11 and Rad50 are two proteins required for DNA repair and meiosis-specific double-strand break formation in <taxon tax_id="4932">Saccharomyces cerevisiae</taxon>. Mre11 by itself has 3' to 5' exonuclease activity that is increased when Mre11 is in a complex with Rad50 [<cite idref="PUB00008183"/>]. </p><p>These eukaryotic proteins contain one metallo-phosphoesterase domain followed by an Mre11 DNA-binding domain. S. cerevisiae Mre11 is required for DNA repair and meiosis-specificdouble-strand break (DSB) formation [<cite idref="PUB00014360"/>] and has both 3' to 5' exonuclease activity (whichincreases when in complex with Rad50) and endonuclease activity. The N-terminal phosphoesterase domain isrequired for DSB repair, and the carboxyl-terminal dsDNA-binding domain is essential during meiosis forchromatin modification and DSB formation [<cite idref="PUB00014392"/>]. <taxon tax_id="4896">Schizosaccharomyces pombe</taxon> rad32 is required for repair of double strand breaks and recombination [<cite idref="PUB00014366"/>].</p> <p>For additional information please see [<cite idref="PUB00008183"/>].</p>