<p>Proteins containing this domain cleave DNA substrates by a series of staggered cuts, during which the protein becomes covalently linked to the DNA through a catalytic tyrosine residue at the carboxy end of the alignment [<cite idref="PUB00005224"/>, <cite idref="PUB00004261"/>].</p><p> The phage integrase N-terminal SAM-like domain is almost always found with the signature that defines the phage integrase family (see <db_xref db="INTERPRO" dbkey="IPR002104"/>).</p>