<p>This family includes the yeast and human ASF1 protein. These proteins have histone chaperone activity [<cite idref="PUB00019146"/>]. ASF1 participates in both the replication-dependent and replication-independent pathways. The structure three-dimensional has been determined as a compact immunoglobulin-like beta sandwich fold topped by three helical linkers [<cite idref="PUB00008590"/>].</p>