SMK-1 is a component of the IIs longevity pathway whichregulates aging in C.elegans. Specifically, SMK-1 influencesDAF-16-dependant regulation of the aging process by regulatingthe transcriptional specificity of DAF-16 activity [1]. SMK-1plays a role in longevity by modulating the transcriptionalspecificity of DAF-16 [1].