This family consists of several eukaryotic fascin or singedproteins. The fascins are a structurally unique andevolutionarily conserved group of actin cross-linking proteins.Fascins function in the organisation of two major forms ofactin-based structures: dynamic, cortical cell protrusions andcytoplasmic microfilament bundles. The cortical structures,which include filopodia, spikes, lamellipodial ribs, oocytemicrovilli and the dendrites of dendritic cells, have roles incell-matrix adhesion, cell interactions and cell migration,whereas the cytoplasmic actin bundles appear to participate incell architecture [1]. Dictyostelium hisactophilin, anotheractin-binding protein, is a submembranous pH sensor that signalsslight changes of the H+ concentration to actin by inducingactin polymerisation and binding to microfilaments only at pHvalues below seven [1]. Members of this family are histidinerich, typically contain the repeated motif of HHXH [3].